PubMed

Amplified hormonal counterregulatory responses to hypoglycemia in rats after systemic delivery of a SUR-1-selective K(+) channel opener?

Fan X, Ding Y, Cheng H, Gram DX, Sherwin RS, McCrimmon RJ.

Diabetes. 2008 Dec;57(12):3327-34. Epub 2008 Sep 5.PMID: 18776135 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats.

McCrimmon RJ, Evans ML, Fan X, McNay EC, Chan O, Ding Y, Zhu W, Gram DX, Sherwin RS.

Diabetes. 2005 Nov;54(11):3169-74.PMID: 16249441 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.

Diabetes. 2004 Jul;53(7):1706-13.PMID: 15220194 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.

Alemzadeh R, Fledelius C, Bodvarsdottir T, Sturis J.

Metabolism. 2004 Apr;53(4):441-7.PMID: 15045689 [PubMed - indexed for MEDLINE]Related articles

NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat.

Carr RD, Brand CL, Bodvarsdottir TB, Hansen JB, Sturis J.

Diabetes. 2003 Oct;52(10):2513-8.PMID: 14514634 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener, in healthy male subjects.

Zdravkovic M, Kruse M, Rost KL, Møss J, Kecskes A, Dyrberg T.

J Clin Pharmacol. 2005 Jul;45(7):763-72.PMID: 15951466 [PubMed - indexed for MEDLINE]Related articles

Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues.

Dabrowski M, Larsen T, Ashcroft FM, Bondo Hansen J, Wahl P.

Diabetologia. 2003 Oct;46(10):1375-82. Epub 2003 Sep 5.PMID: 12961066 [PubMed - indexed for MEDLINE]Related articles

Improved beta-cell survival and reduced insulitis in a type 1 diabetic rat model after treatment with a beta-cell-selective K(ATP) channel opener.

Skak K, Gotfredsen CF, Lundsgaard D, Hansen JB, Sturis J, Markholst H.

Diabetes. 2004 Apr;53(4):1089-95.PMID: 15047626 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.

Ritzel RA, Hansen JB, Veldhuis JD, Butler PC.

J Clin Endocrinol Metab. 2004 Feb;89(2):795-805.PMID: 14764798 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses.

Evans ML, McCrimmon RJ, Flanagan DE, Keshavarz T, Fan X, McNay EC, Jacob RJ, Sherwin RS.

Diabetes. 2004 Oct;53(10):2542-51.PMID: 15448082 [PubMed - indexed for MEDLINE]Related articlesFree article

Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.

Hansen JB.

Curr Med Chem. 2006;13(4):361-76. Review.PMID: 16475928 [PubMed - indexed for MEDLINE]Related articles

ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia.

Chan O, Lawson M, Zhu W, Beverly JL, Sherwin RS.

Diabetes. 2007 Apr;56(4):1120-6. Epub 2007 Jan 24.PMID: 17251273 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP.

Jin JY, Park SH, Bae JH, Cho HC, Lim JG, Park WS, Han J, Lee JH, Song DK.

Pharmacol Res. 2007 Sep;56(3):237-47. Epub 2007 Jun 21.PMID: 17656102 [PubMed - indexed for MEDLINE]Related articles

New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.

Nielsen FE, Ebdrup S, Jensen AF, Ynddal L, Bodvarsdottir TB, Stidsen C, Worsaae A, Boonen HC, Arkhammar PO, Fremming T, Wahl P, Kornø HT, Hansen JB.

J Med Chem. 2006 Jul 13;49(14):4127-39.PMID: 16821773 [PubMed - indexed for MEDLINE]Related articles

Effects of caudal hindbrain lactate infusion on insulin-induced hypoglycemia and neuronal substrate transporter glucokinase and sulfonylurea receptor-1 gene expression in the ovariectomized female rat dorsal vagal complex: Impact of estradiol.

Vavaiya KV, Briski KP.

J Neurosci Res. 2008 Feb 15;86(3):694-701.PMID: 17941059 [PubMed - indexed for MEDLINE]Related articles

Lipids modulate ligand binding to sulphonylurea receptors.

Klein A, Lichtenberg J, Stephan D, Quast U.

Br J Pharmacol. 2005 Aug;145(7):907-15.PMID: 15895108 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats. Reversibility and stimulus specificity of the deficits.

Powell AM, Sherwin RS, Shulman GI.

J Clin Invest. 1993 Dec;92(6):2667-74.PMID: 8254023 [PubMed - indexed for MEDLINE]Related articlesFree article

Iptakalim modulates ATP-sensitive K(+) channels in dopamine neurons from rat substantia nigra pars compacta.

Wu J, Hu J, Chen YP, Takeo T, Suga S, Dechon J, Liu Q, Yang KC, St John PA, Hu G, Wang H, Wakui M.

J Pharmacol Exp Ther. 2006 Oct;319(1):155-64. Epub 2006 Jul 12.PMID: 16837559 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener in subjects with type 2 diabetes.

Zdravkovic M, Kruse M, Rost KL, Møss J, Kecskes A.

Exp Clin Endocrinol Diabetes. 2007 Jun;115(6):405-6.PMID: 17701889 [PubMed - indexed for MEDLINE]Related articles

ABCC8 and ABCC9: ABC transporters that regulate K+ channels.

Bryan J, Muñoz A, Zhang X, Düfer M, Drews G, Krippeit-Drews P, Aguilar-Bryan L.

Pflugers Arch. 2007 Feb;453(5):703-18. Epub 2006 Aug 8. Review.PMID: 16897043 [PubMed - indexed for MEDLINE]Related articles