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Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats.

Nogueiras R, Veyrat-Durebex C, Suchanek PM, Klein M, Tschöp J, Caldwell C, Woods SC, Wittmann G, Watanabe M, Liposits Z, Fekete C, Reizes O, Rohner-Jeanrenaud F, Tschöp MH.

Diabetes. 2008 Nov;57(11):2977-91. Epub 2008 Aug 20.PMID: 18716045 [PubMed - indexed for MEDLINE]Related articlesFree article

Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism.

Cota D, Sandoval DA, Olivieri M, Prodi E, D'Alessio DA, Woods SC, Seeley RJ, Obici S.

Obesity (Silver Spring). 2009 Aug;17(8):1641-5. Epub 2009 Mar 26.PMID: 19325539 [PubMed - indexed for MEDLINE]Related articles

The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake.

Thornton-Jones ZD, Kennett GA, Benwell KR, Revell DF, Misra A, Sellwood DM, Vickers SP, Clifton PG.

Pharmacol Biochem Behav. 2006 Jun;84(2):353-9. Epub 2006 Jun 30.PMID: 16814374 [PubMed - indexed for MEDLINE]Related articles

The endocannabinoid system: a new target for the regulation of energy balance and metabolism.

Després JP.

Crit Pathw Cardiol. 2007 Jun;6(2):46-50. Review.PMID: 17667864 [PubMed - indexed for MEDLINE]Related articles

CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity.

Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrié P.

Int J Obes Relat Metab Disord. 2004 Apr;28(4):640-8.PMID: 14770190 [PubMed - indexed for MEDLINE]Related articles

The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats.

Serrano A, Del Arco I, Javier Pavón F, Macías M, Perez-Valero V, Rodríguez de Fonseca F.

Neuropharmacology. 2008 Jan;54(1):226-34. Epub 2007 Mar 24.PMID: 17467748 [PubMed - indexed for MEDLINE]Related articles

Effects on food intake and blood lipids of cannabinoid receptor 1 antagonist treatment in lean rats.

Bennetzen MF, Nielsen MP, Richelsen B, Pedersen SB.

Obesity (Silver Spring). 2008 Nov;16(11):2451-5. Epub 2008 Aug 14.PMID: 18719671 [PubMed - indexed for MEDLINE]Related articles

The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance.

Jbilo O, Ravinet-Trillou C, Arnone M, Buisson I, Bribes E, Péleraux A, Pénarier G, Soubrié P, Le Fur G, Galiègue S, Casellas P.

FASEB J. 2005 Sep;19(11):1567-9. Epub 2005 Jul 11.PMID: 16009704 [PubMed - indexed for MEDLINE]Related articlesFree article

Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats.

Pavón FJ, Serrano A, Pérez-Valero V, Jagerovic N, Hernández-Folgado L, Bermúdez-Silva FJ, Macías M, Goya P, de Fonseca FR.

J Neuroendocrinol. 2008 May;20 Suppl 1:116-23. Review.PMID: 18426510 [PubMed - indexed for MEDLINE]Related articles

Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats.

Janiak P, Poirier B, Bidouard JP, Cadrouvele C, Pierre F, Gouraud L, Barbosa I, Dedio J, Maffrand JP, Le Fur G, O'Connor S, Herbert JM.

Kidney Int. 2007 Dec;72(11):1345-57. Epub 2007 Sep 19.PMID: 17882151 [PubMed - indexed for MEDLINE]Related articles

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.

Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G, Vonderfecht S, Hecht R, Li YS, Lindberg RA, Chen JL, Jung DY, Zhang Z, Ko HJ, Kim JK, Véniant MM.

Diabetes. 2009 Jan;58(1):250-9. Epub 2008 Oct 7.PMID: 18840786 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice.

Irwin N, Hunter K, Flatt PR.

Peptides. 2008 Jun;29(6):1036-41. Epub 2008 Jan 18.PMID: 18291559 [PubMed - indexed for MEDLINE]Related articles

Understanding metabolic homeostasis and imbalance: what is the role of the endocannabinoid system?

Kunos G.

Am J Med. 2007 Sep;120(9 Suppl 1):S18-24; discussion S24. Review.PMID: 17720356 [PubMed - indexed for MEDLINE]Related articles

Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice.

Irwin N, Hunter K, Frizzell N, Flatt PR.

Eur J Pharmacol. 2008 Feb 26;581(1-2):226-33. Epub 2007 Dec 14.PMID: 18191122 [PubMed - indexed for MEDLINE]Related articles

Ghrelin action in the brain controls adipocyte metabolism.

Theander-Carrillo C, Wiedmer P, Cettour-Rose P, Nogueiras R, Perez-Tilve D, Pfluger P, Castaneda TR, Muzzin P, Schürmann A, Szanto I, Tschöp MH, Rohner-Jeanrenaud F.

J Clin Invest. 2006 Jul;116(7):1983-93. Epub 2006 Jun 8.PMID: 16767221 [PubMed - indexed for MEDLINE]Related articlesFree article

Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice.

Hildebrandt AL, Kelly-Sullivan DM, Black SC.

Eur J Pharmacol. 2003 Feb 21;462(1-3):125-32.PMID: 12591104 [PubMed - indexed for MEDLINE]Related articles

Reversal of visceral adiposity in candy-diet fed female Wistar rats by the CB1 receptor antagonist rimonabant.

Herling AW, Kilp S, Juretschke HP, Neumann-Haefelin C, Gerl M, Kramer W.

Int J Obes (Lond). 2008 Sep;32(9):1363-72. Epub 2008 Jul 15.PMID: 18626484 [PubMed - indexed for MEDLINE]Related articles

CB1 receptor antagonist AVE1625 affects primarily metabolic parameters independently of reduced food intake in Wistar rats.

Herling AW, Gossel M, Haschke G, Stengelin S, Kuhlmann J, Müller G, Schmoll D, Kramer W.

Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E826-32. Epub 2007 Jun 26.PMID: 17595216 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice.

Liu YL, Connoley IP, Wilson CA, Stock MJ.

Int J Obes (Lond). 2005 Feb;29(2):183-7.PMID: 15558076 [PubMed - indexed for MEDLINE]Related articles

Effects of adolescent nicotine and SR 147778 (Surinabant) administration on food intake, somatic growth and metabolic parameters in rats.

Lamota L, Bermudez-Silva FJ, Marco EM, Llorente R, Gallego A, Rodríguez de Fonseca F, Viveros MP.

Neuropharmacology. 2008 Jan;54(1):194-205. Epub 2007 Jul 19.PMID: 17720206 [PubMed - indexed for MEDLINE]Related articles