PubMed

Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep.

Waerhaug K, Kuklin VN, Kirov MY, Sovershaev MA, Langbakk B, Ingebretsen OC, Ytrehus K, Bjertnaes LJ.

Crit Care. 2008;12(4):R104. Epub 2008 Aug 15.PMID: 18702832 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human activated protein C ameliorates oleic acid-induced lung injury in awake sheep.

Waerhaug K, Kirov MY, Kuzkov VV, Kuklin VN, Bjertnaes LJ.

Crit Care. 2008;12(6):R146. Epub 2008 Nov 20.PMID: 19021914 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis.

Maybauer MO, Maybauer DM, Fraser JF, Traber LD, Westphal M, Enkhbaatar P, Cox RA, Huda R, Hawkins HK, Morita N, Murakami K, Mizutani A, Herndon DN, Traber DL.

Crit Care Med. 2006 Sep;34(9):2432-8.PMID: 16810106 [PubMed - indexed for MEDLINE]Related articles

Inhaled aerosolised recombinant human activated protein C ameliorates endotoxin-induced lung injury in anaesthetised sheep.

Waerhaug K, Kuzkov VV, Kuklin VN, Mortensen R, Nordhus KC, Kirov MY, Bjertnaes LJ.

Crit Care. 2009;13(2):R51. Epub 2009 Apr 8.PMID: 19356243 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis.

Nick JA, Coldren CD, Geraci MW, Poch KR, Fouty BW, O'Brien J, Gruber M, Zarini S, Murphy RC, Kuhn K, Richter D, Kast KR, Abraham E.

Blood. 2004 Dec 15;104(13):3878-85. Epub 2004 Aug 31. Erratum in: Blood. 2005 May 15;105(10):3785. PMID: 15339848 [PubMed - indexed for MEDLINE]Related articlesFree article

Intravenous administration of activated protein C in Pseudomonas-induced lung injury: impact on lung fluid balance and the inflammatory response.

Robriquet L, Collet F, Tournoys A, Prangère T, Nevière R, Fourrier F, Guery BP.

Respir Res. 2006 Mar 22;7:41.PMID: 16553944 [PubMed - indexed for MEDLINE]Related articlesFree article

Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C.

Kuklin V, Kirov M, Sovershaev M, Andreasen T, Ingebretsen OC, Ytrehus K, Bjertnaes L.

Crit Care. 2005 Jun;9(3):R211-7. Epub 2005 Mar 14.PMID: 15987392 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of activated protein C on coagulation and fibrinolysis in rabbits with endotoxin induced acute lung injury.

He HY, Wang C, Pang BS.

Chin Med J (Engl). 2008 Dec 20;121(24):2561-5.PMID: 19187596 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated]) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia.

Derhaschnig U, Reiter R, Knöbl P, Baumgartner M, Keen P, Jilma B.

Blood. 2003 Sep 15;102(6):2093-8. Epub 2003 May 15.PMID: 12750166 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel endothelin receptor antagonist attenuates endotoxin-induced lung injury in sheep.

Kuklin VN, Kirov MY, Evgenov OV, Sovershaev MA, Sjöberg J, Kirova SS, Bjertnaes LJ.

Crit Care Med. 2004 Mar;32(3):766-73.PMID: 15090960 [PubMed - indexed for MEDLINE]Related articles

Granulocyte colony-stimulating factor does not exacerbate endotoxin-induced lung injury in sheep.

Koizumi T, Kubo K, Shinozaki S, Koyama S, Kobayashi T, Sekiguchi M.

Am Rev Respir Dis. 1993 Jul;148(1):132-7.PMID: 7686356 [PubMed - indexed for MEDLINE]Related articles

Effects of recombinant human activated protein C in human models of endotoxin administration.

Abraham E.

Proc Am Thorac Soc. 2005;2(3):243-7. Review.PMID: 16222045 [PubMed - indexed for MEDLINE]Related articlesFree article

Aerosolized linear polyethylenimine-nitric oxide/nucleophile adduct attenuates endotoxin-induced lung injury in sheep.

Kirov MY, Evgenov OV, Kuklin VN, Virag L, Pacher P, Southan GJ, Salzman AL, Szabo C, Bjertnaes LJ.

Am J Respir Crit Care Med. 2002 Dec 1;166(11):1436-42.PMID: 12450933 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination of intravenously infused methylene blue and inhaled nitric oxide ameliorates endotoxin-induced lung injury in awake sheep.

Kirov MY, Evgenov OV, Bjertnaes LJ.

Crit Care Med. 2003 Jan;31(1):179-86.PMID: 12545013 [PubMed - indexed for MEDLINE]Related articles

Activated protein C attenuates intestinal reperfusion-induced acute lung injury: an experimental study in a rat model.

Teke Z, Sacar M, Yenisey C, Atalay AO, Bicakci T, Erdem E.

Am J Surg. 2008 Jun;195(6):861-73.PMID: 18367148 [PubMed - indexed for MEDLINE]Related articles

Recombinant human activated protein C resets thrombin generation in patients with severe sepsis - a case control study.

de Pont AC, Bakhtiari K, Hutten BA, de Jonge E, Vroom MB, Meijers JC, Büller HR, Levi M.

Crit Care. 2005 Oct 5;9(5):R490-7. Epub 2005 Jul 21.PMID: 16277710 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment.

Slofstra SH, Groot AP, Maris NA, Reitsma PH, Cate HT, Spek CA.

Br J Pharmacol. 2006 Nov;149(6):740-6. Epub 2006 Oct 3.PMID: 17016502 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated protein C reduces endotoxin-induced white matter injury in the developing rat brain.

Yesilirmak DC, Kumral A, Baskin H, Ergur BU, Aykan S, Genc S, Genc K, Yilmaz O, Tugyan K, Giray O, Duman N, Ozkan H.

Brain Res. 2007 Aug 20;1164:14-23. Epub 2007 May 23.PMID: 17644074 [PubMed - indexed for MEDLINE]Related articles

Bactericidal/permeability-increasing protein attenuates systemic inflammation and acute lung injury in porcine lower limb ischemia-reperfusion injury.

Harkin DW, Barros D'Sa AA, McCallion K, Hoper M, Halliday MI, Campbell FC.

Ann Surg. 2001 Aug;234(2):233-44.PMID: 11505070 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of nitric oxide synthesis inhibition in hyperdynamic endotoxemia.

Meyer J, Lentz CW, Stothert JC Jr, Traber LD, Herndon DN, Traber DL.

Crit Care Med. 1994 Feb;22(2):306-12.PMID: 8306691 [PubMed - indexed for MEDLINE]Related articles