PubMed

Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.

Marzban L, Tomas A, Becker TC, Rosenberg L, Oberholzer J, Fraser PE, Halban PA, Verchere CB.

Diabetes. 2008 Nov;57(11):3045-55. Epub 2008 Aug 11.PMID: 18694973 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.

Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, Verchere CB.

Diabetes. 2006 Aug;55(8):2192-201.PMID: 16873681 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.

Hull RL, Zraika S, Udayasankar J, Kisilevsky R, Szarek WA, Wight TN, Kahn SE.

Am J Physiol Cell Physiol. 2007 Nov;293(5):C1586-93. Epub 2007 Sep 5.PMID: 17804609 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets.

Paulsson JF, Andersson A, Westermark P, Westermark GT.

Diabetologia. 2006 Jun;49(6):1237-46. Epub 2006 Mar 29.PMID: 16570161 [PubMed - indexed for MEDLINE]Related articles

Expression of human islet amyloid polypeptide/amylin impairs insulin secretion in mouse pancreatic beta cells.

Tokuyama T, Yagui K, Yamaguchi T, Huang CI, Kuramoto N, Shimada F, Miyazaki J, Horie H, Saito Y, Makino H, Kanatsuka A.

Metabolism. 1997 Sep;46(9):1044-51.PMID: 9284894 [PubMed - indexed for MEDLINE]Related articles

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

de Koning EJ, Morris ER, Hofhuis FM, Posthuma G, Höppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS.

Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8467-71.PMID: 8078905 [PubMed - indexed for MEDLINE]Related articlesFree article

Amyloid inhibitors enhance survival of cultured human islets.

Potter KJ, Scrocchi LA, Warnock GL, Ao Z, Younker MA, Rosenberg L, Lipsett M, Verchere CB, Fraser PE.

Biochim Biophys Acta. 2009 Jun;1790(6):566-74. Epub 2009 Mar 2.PMID: 19264107 [PubMed - indexed for MEDLINE]Related articles

Regulation of islet amyloid polypeptide in human pancreatic islets.

Novials A, Sarri Y, Casamitjana R, Rivera F, Gomis R.

Diabetes. 1993 Oct;42(10):1514-9.PMID: 8375592 [PubMed - indexed for MEDLINE]Related articles

Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC.

J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86. Epub 2005 Oct 4.PMID: 16204373 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid polypeptide and type 2 diabetes.

Marzban L, Park K, Verchere CB.

Exp Gerontol. 2003 Apr;38(4):347-51. Review.PMID: 12670620 [PubMed - indexed for MEDLINE]Related articles

Amyloidogenicity of recombinant human pro-islet amyloid polypeptide (ProIAPP).

Krampert M, Bernhagen J, Schmucker J, Horn A, Schmauder A, Brunner H, Voelter W, Kapurniotu A.

Chem Biol. 2000 Nov;7(11):855-71.PMID: 11094339 [PubMed - indexed for MEDLINE]Related articles

Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

Ritzel RA, Butler PC.

Diabetes. 2003 Jul;52(7):1701-8.PMID: 12829636 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid polypeptide: mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus.

Johnson KH, O'Brien TD, Betsholtz C, Westermark P.

Lab Invest. 1992 May;66(5):522-35. Review.PMID: 1573849 [PubMed - indexed for MEDLINE]Related articles

Amyloid fibril formation is progressive and correlates with beta-cell secretion in transgenic mouse isolated islets.

MacArthur DL, de Koning EJ, Verbeek JS, Morris JF, Clark A.

Diabetologia. 1999 Oct;42(10):1219-27.PMID: 10525663 [PubMed - indexed for MEDLINE]Related articles

beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress.

Hull RL, Zraika S, Udayasankar J, Aston-Mourney K, Subramanian SL, Kahn SE.

Diabetologia. 2009 Jun;52(6):1102-11. Epub 2009 Apr 8.PMID: 19352619 [PubMed - indexed for MEDLINE]Related articles

Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.

Jaikaran ET, Clark A.

Biochim Biophys Acta. 2001 Nov 29;1537(3):179-203. Review.PMID: 11731221 [PubMed - indexed for MEDLINE]Related articles

An in vitro model of early islet amyloid polypeptide (IAPP) fibrillogenesis using human IAPP-transgenic mouse islets.

Henson MS, Buman BL, Jordan K, Rahrmann EP, Hardy RM, Johnson KH, O'Brien TD.

Amyloid. 2006 Dec;13(4):250-9.PMID: 17107885 [PubMed - indexed for MEDLINE]Related articles

Newly identified pancreatic protein islet amyloid polypeptide. What is its relationship to diabetes?

Johnson KH, O'Brien TD, Westermark P.

Diabetes. 1991 Mar;40(3):310-4. Review.PMID: 1999270 [PubMed - indexed for MEDLINE]Related articles

Formation of islet amyloid fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin.

Yagui K, Yamaguchi T, Kanatsuka A, Shimada F, Huang CI, Tokuyama Y, Ohsawa H, Yamamura K, Miyazaki J, Mikata A, et al.

Eur J Endocrinol. 1995 Apr;132(4):487-96.PMID: 7711888 [PubMed - indexed for MEDLINE]Related articles