PubMed

Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity.

Filippi CM, Juedes AE, Oldham JE, Ling E, Togher L, Peng Y, Flavell RA, von Herrath MG.

Diabetes. 2008 Oct;57(10):2684-92. Epub 2008 Aug 8.PMID: 18689691 [PubMed - indexed for MEDLINE]Related articlesFree article

Infiltration of tumor-reactive transforming growth factor-beta insensitive CD8+ T cells into the tumor parenchyma is associated with apoptosis and rejection of tumor cells.

Zhang Q, Jang TL, Yang X, Park I, Meyer RE, Kundu S, Pins M, Javonovic B, Kuzel T, Kim SJ, Van Parijs L, Smith N, Wong L, Greenberg NM, Guo Y, Lee C.

Prostate. 2006 Feb 15;66(3):235-47.PMID: 16173028 [PubMed - indexed for MEDLINE]Related articles

Clonal restriction of the expansion of antigen-specific CD8+ memory T cells by transforming growth factor-{beta}.

Cheng ML, Chen HW, Tsai JP, Lee YP, Shih YC, Chang CM, Ting CC.

J Leukoc Biol. 2006 May;79(5):1033-42. Epub 2006 Feb 14.PMID: 16478921 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model.

Karpouzas GA, La Cava A, Ebling FM, Singh RR, Hahn BH.

Eur J Immunol. 2004 Sep;34(9):2489-99.PMID: 15307181 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8+ T cell growth and apoptosis.

Rich S, Van Nood N, Lee HM.

J Immunol. 1996 Oct 1;157(7):2916-23.PMID: 8816397 [PubMed - indexed for MEDLINE]Related articles

Blockade of transforming growth factor-{beta} signaling in tumor-reactive CD8(+) T cells activates the antitumor immune response cycle.

Zhang Q, Yang XJ, Kundu SD, Pins M, Javonovic B, Meyer R, Kim SJ, Greenberg NM, Kuzel T, Meagher R, Guo Y, Lee C.

Mol Cancer Ther. 2006 Jul;5(7):1733-43.PMID: 16891459 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor beta 1 costimulated growth and regulatory function of staphylococcal enterotoxin B-responsive CD8+ T cells.

Rich S, Seelig M, Lee HM, Lin J.

J Immunol. 1995 Jul 15;155(2):609-18.PMID: 7608539 [PubMed - indexed for MEDLINE]Related articles

CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes.

Green EA, Gorelik L, McGregor CM, Tran EH, Flavell RA.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10878-83. Epub 2003 Aug 29.PMID: 12949259 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta inhibits human antigen-specific CD4+ T cell proliferation without modulating the cytokine response.

Tiemessen MM, Kunzmann S, Schmidt-Weber CB, Garssen J, Bruijnzeel-Koomen CA, Knol EF, van Hoffen E.

Int Immunol. 2003 Dec;15(12):1495-504.PMID: 14645158 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-15 induces type 1 and type 2 CD4+ and CD8+ T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12 / IL-4 stimulation in vitro.

Niedbala W, Wei X, Liew FY.

Eur J Immunol. 2002 Feb;32(2):341-7.PMID: 11807773 [PubMed - indexed for MEDLINE]Related articles

Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo.

Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI.

Immunity. 2009 Jul 17;31(1):145-57.PMID: 19604493 [PubMed - indexed for MEDLINE]Related articles

Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity.

Riboulet-Chavey A, Diraison F, Siew LK, Wong FS, Rutter GA.

Diabetes. 2008 Feb;57(2):415-23. Epub 2007 Nov 14.PMID: 18003756 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro generation of regulatory CD8+ T cells similar to those found in mice with anterior chamber-associated immune deviation.

Kezuka T, Streilein JW.

Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1803-11.PMID: 10845601 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct effects of TGF-beta 1 on CD4+ and CD8+ T cell survival, division, and IL-2 production: a role for T cell intrinsic Smad3.

McKarns SC, Schwartz RH.

J Immunol. 2005 Feb 15;174(4):2071-83.PMID: 15699137 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of TGF-beta1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells.

Lúdvíksson BR, Seegers D, Resnick AS, Strober W.

Eur J Immunol. 2000 Jul;30(7):2101-11.PMID: 10940900 [PubMed - indexed for MEDLINE]Related articles

Deletion, but not anergy, is involved in TGF-beta-treated antigen-presenting cell-induced tolerance.

Alard P, Clark SL, Kosiewicz MM.

Int Immunol. 2003 Aug;15(8):945-53.PMID: 12882832 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice.

Han J, Zhong J, Wei W, Wang Y, Huang Y, Yang P, Purohit S, Dong Z, Wang MH, She JX, Gong F, Stern DM, Wang CY.

Diabetes. 2008 Aug;57(8):2118-27. Epub 2008 May 13.PMID: 18477810 [PubMed - indexed for MEDLINE]Related articlesFree article

CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance.

Keino H, Masli S, Sasaki S, Streilein JW, Stein-Streilein J.

Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1533-42.PMID: 16565389 [PubMed - indexed for MEDLINE]Related articlesFree article

Perturbed homeostasis of peripheral T cells elicits decreased susceptibility to anti-CD3-induced apoptosis in prediabetic nonobese diabetic mice.

Yang W, Hussain S, Mi QS, Santamaria P, Delovitch TL.

J Immunol. 2004 Oct 1;173(7):4407-16.PMID: 15383571 [PubMed - indexed for MEDLINE]Related articlesFree article

Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 1. Inhibition of T-cell activation in vitro by direct cell-to-cell contact.

Yoshida M, Takeuchi M, Streilein JW.

Invest Ophthalmol Vis Sci. 2000 Mar;41(3):811-21.PMID: 10711698 [PubMed - indexed for MEDLINE]Related articlesFree article