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Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling.

Ando H, Izawa S, Hori W, Nakagawa I.

Theor Biol Med Model. 2008 Aug 8;5:19. Erratum in: Theor Biol Med Model. 2009;6:29. PMID: 18687151 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of a generic physiologically based pharmacokinetic model for lineshape analysis.

Peters SA.

Clin Pharmacokinet. 2008;47(4):261-75.PMID: 18336055 [PubMed - indexed for MEDLINE]Related articles

Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.

De Buck SS, Sinha VK, Fenu LA, Nijsen MJ, Mackie CE, Gilissen RA.

Drug Metab Dispos. 2007 Oct;35(10):1766-80. Epub 2007 Jul 9.PMID: 17620347 [PubMed - indexed for MEDLINE]Related articlesFree article

A whole-body physiologically based pharmacokinetic model incorporating dispersion concepts: short and long time characteristics.

Oliver RE, Jones AF, Rowland M.

J Pharmacokinet Pharmacodyn. 2001 Feb;28(1):27-55.PMID: 11253612 [PubMed - indexed for MEDLINE]Related articles

A novel strategy for physiologically based predictions of human pharmacokinetics.

Jones HM, Parrott N, Jorga K, Lavé T.

Clin Pharmacokinet. 2006;45(5):511-42.PMID: 16640456 [PubMed - indexed for MEDLINE]Related articles

Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.

Rodgers T, Rowland M.

J Pharm Sci. 2006 Jun;95(6):1238-57. Erratum in: J Pharm Sci. 2007 Nov;96(11):3153-4. PMID: 16639716 [PubMed - indexed for MEDLINE]Related articles

Development and evaluation of a generic physiologically based pharmacokinetic model for children.

Edginton AN, Schmitt W, Willmann S.

Clin Pharmacokinet. 2006;45(10):1013-34.PMID: 16984214 [PubMed - indexed for MEDLINE]Related articles

Reduction and lumping of physiologically based pharmacokinetic models: prediction of the disposition of fentanyl and pethidine in humans by successively simplified models.

Björkman S.

J Pharmacokinet Pharmacodyn. 2003 Aug;30(4):285-307.PMID: 14650375 [PubMed - indexed for MEDLINE]Related articles

Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.

Fagerholm U.

J Pharm Pharmacol. 2007 Jun;59(6):803-28.PMID: 17637173 [PubMed - indexed for MEDLINE]Related articles

Prediction of pharmacokinetic profile of valsartan in humans based on in vitro uptake-transport data.

Poirier A, Cascais AC, Funk C, Lavé T.

Chem Biodivers. 2009 Nov;6(11):1975-87.PMID: 19937834 [PubMed - indexed for MEDLINE]Related articles

Prediction of human pharmacokinetics--improving microsome-based predictions of hepatic metabolic clearance.

Fagerholm U.

J Pharm Pharmacol. 2007 Oct;59(10):1427-31.PMID: 17910819 [PubMed - indexed for MEDLINE]Related articles

Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition.

Poulin P, Theil FP.

J Pharm Sci. 2002 May;91(5):1358-70.PMID: 11977112 [PubMed - indexed for MEDLINE]Related articles

Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic model.

Björkman S, Wada DR, Berling BM, Benoni G.

J Pharm Sci. 2001 Sep;90(9):1226-41.PMID: 11745776 [PubMed - indexed for MEDLINE]Related articles

Diazepam pharamacokinetics from preclinical to phase I using a Bayesian population physiologically based pharmacokinetic model with informative prior distributions in WinBUGS.

Gueorguieva I, Aarons L, Rowland M.

J Pharmacokinet Pharmacodyn. 2006 Oct;33(5):571-94. Epub 2006 Jun 29.PMID: 16810558 [PubMed - indexed for MEDLINE]Related articles

Exploratory population pharmacokinetics (e-PPK) analysis for predicting human PK using exploratory ADME data during early drug discovery research.

Tabata K, Hamakawa N, Sanoh S, Terashita S, Teramura T.

Eur J Drug Metab Pharmacokinet. 2009 Apr-Jun;34(2):117-28.PMID: 19645221 [PubMed - indexed for MEDLINE]Related articles

Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs.

Björkman S.

Br J Clin Pharmacol. 2005 Jun;59(6):691-704.PMID: 15948934 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine.

Poirier A, Funk C, Scherrmann JM, Lavé T.

Mol Pharm. 2009 Nov-Dec;6(6):1716-33.PMID: 19739673 [PubMed - indexed for MEDLINE]Related articles

An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery.

Parrott N, Paquereau N, Coassolo P, Lavé T.

J Pharm Sci. 2005 Oct;94(10):2327-43.PMID: 16136543 [PubMed - indexed for MEDLINE]Related articles

Prediction of changes in the clinical pharmacokinetics of basic drugs on the basis of octanol-water partition coefficients.

Ishizaki J, Yokogawa K, Nakashima E, Ichimura F.

J Pharm Pharmacol. 1997 Aug;49(8):762-7.PMID: 9379352 [PubMed - indexed for MEDLINE]Related articles

The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools.

De Buck SS, Sinha VK, Fenu LA, Gilissen RA, Mackie CE, Nijsen MJ.

Drug Metab Dispos. 2007 Apr;35(4):649-59. Epub 2007 Jan 31.PMID: 17267621 [PubMed - indexed for MEDLINE]Related articlesFree article