PubMed

Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients.

Phielix E, Schrauwen-Hinderling VB, Mensink M, Lenaers E, Meex R, Hoeks J, Kooi ME, Moonen-Kornips E, Sels JP, Hesselink MK, Schrauwen P.

Diabetes. 2008 Nov;57(11):2943-9. Epub 2008 Aug 4.PMID: 18678616 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects.

Schrauwen-Hinderling VB, Kooi ME, Hesselink MK, Jeneson JA, Backes WH, van Echteld CJ, van Engelshoven JM, Mensink M, Schrauwen P.

Diabetologia. 2007 Jan;50(1):113-20. Epub 2006 Nov 9.PMID: 17093944 [PubMed - indexed for MEDLINE]Related articles

Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus.

Mensink M, Hesselink MK, Russell AP, Schaart G, Sels JP, Schrauwen P.

Int J Obes (Lond). 2007 Aug;31(8):1302-10. Epub 2007 Feb 20.PMID: 17310221 [PubMed - indexed for MEDLINE]Related articles

Impact of exercise training on insulin sensitivity, physical fitness, and muscle oxidative capacity in first-degree relatives of type 2 diabetic patients.

Østergård T, Andersen JL, Nyholm B, Lund S, Nair KS, Saltin B, Schmitz O.

Am J Physiol Endocrinol Metab. 2006 May;290(5):E998-1005. Epub 2005 Dec 13.PMID: 16352678 [PubMed - indexed for MEDLINE]Related articlesFree article

Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle.

Boushel R, Gnaiger E, Schjerling P, Skovbro M, Kraunsøe R, Dela F.

Diabetologia. 2007 Apr;50(4):790-6. Epub 2007 Feb 15.PMID: 17334651 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose turnover and adipose tissue lipolysis are insulin-resistant in healthy relatives of type 2 diabetes patients: is cellular insulin resistance a secondary phenomenon?

Eriksson JW, Smith U, Waagstein F, Wysocki M, Jansson PA.

Diabetes. 1999 Aug;48(8):1572-8.PMID: 10426375 [PubMed - indexed for MEDLINE]Related articlesFree article

The insulin-sensitizing effect of rosiglitazone in type 2 diabetes mellitus patients does not require improved in vivo muscle mitochondrial function.

Schrauwen-Hinderling VB, Mensink M, Hesselink MK, Sels JP, Kooi ME, Schrauwen P.

J Clin Endocrinol Metab. 2008 Jul;93(7):2917-21. Epub 2008 May 6.PMID: 18460571 [PubMed - indexed for MEDLINE]Related articlesFree article

Study of regulation of mitochondrial respiration in vivo. An analysis of influence of ADP diffusion and possible role of cytoskeleton.

Kay L, Li Z, Mericskay M, Olivares J, Tranqui L, Fontaine E, Tiivel T, Sikk P, Kaambre T, Samuel JL, Rappaport L, Usson Y, Leverve X, Paulin D, Saks VA.

Biochim Biophys Acta. 1997 Nov 10;1322(1):41-59.PMID: 9398078 [PubMed - indexed for MEDLINE]Related articles

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.

Petersen KF, Dufour S, Shulman GI.

PLoS Med. 2005 Sep;2(9):e233. Epub 2005 Aug 16.PMID: 16089501 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammation, insulin resistance, and adiposity: a study of first-degree relatives of type 2 diabetic subjects.

Kriketos AD, Greenfield JR, Peake PW, Furler SM, Denyer GS, Charlesworth JA, Campbell LV.

Diabetes Care. 2004 Aug;27(8):2033-40.PMID: 15277436 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes.

Szendroedi J, Schmid AI, Chmelik M, Toth C, Brehm A, Krssak M, Nowotny P, Wolzt M, Waldhausl W, Roden M.

PLoS Med. 2007 May;4(5):e154.PMID: 17472434 [PubMed - indexed for MEDLINE]Related articlesFree article

Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction.

De Feyter HM, van den Broek NM, Praet SF, Nicolay K, van Loon LJ, Prompers JJ.

Eur J Endocrinol. 2008 May;158(5):643-53.PMID: 18426822 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscular mitochondrial dysfunction and type 2 diabetes mellitus.

Schrauwen-Hinderling VB, Roden M, Kooi ME, Hesselink MK, Schrauwen P.

Curr Opin Clin Nutr Metab Care. 2007 Nov;10(6):698-703. Review.PMID: 18089950 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes.

Mogensen M, Sahlin K, Fernström M, Glintborg D, Vind BF, Beck-Nielsen H, Højlund K.

Diabetes. 2007 Jun;56(6):1592-9. Epub 2007 Mar 9.PMID: 17351150 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice.

Yokota T, Kinugawa S, Hirabayashi K, Matsushima S, Inoue N, Ohta Y, Hamaguchi S, Sobirin MA, Ono T, Suga T, Kuroda S, Tanaka S, Terasaki F, Okita K, Tsutsui H.

Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1069-77. Epub 2009 Jul 17.PMID: 19617406 [PubMed - indexed for MEDLINE]Related articles

Site of insulin resistance in type 1 diabetes: insulin-mediated glucose disposal in vivo in relation to insulin binding and action in adipocytes in vitro.

Yki-Järvinen H, Taskinen MR, Kiviluoto T, Hilden H, Helve E, Koivisto VA, Nikkilä EA.

J Clin Endocrinol Metab. 1984 Dec;59(6):1183-92.PMID: 6490795 [PubMed - indexed for MEDLINE]Related articles

Are substrate use during exercise and mitochondrial respiratory capacity decreased in arm and leg muscle in type 2 diabetes?

Larsen S, Ara I, Rabøl R, Andersen JL, Boushel R, Dela F, Helge JW.

Diabetologia. 2009 Jul;52(7):1400-8. Epub 2009 Apr 25.PMID: 19396425 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetes mellitus and skeletal muscle metabolic function.

Phielix E, Mensink M.

Physiol Behav. 2008 May 23;94(2):252-8. Epub 2008 Jan 31. Review.PMID: 18342897 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation.

Båvenholm PN, Kuhl J, Pigon J, Saha AK, Ruderman NB, Efendic S.

J Clin Endocrinol Metab. 2003 Jan;88(1):82-7. Erratum in: J Clin Endocrinol Metab. 2003 May;88(5):2036. PMID: 12519834 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence of increased visceral obesity and reduced physical fitness in healthy insulin-resistant first-degree relatives of type 2 diabetic patients.

Nyholm B, Nielsen MF, Kristensen K, Nielsen S, Østergård T, Pedersen SB, Christiansen T, Richelsen B, Jensen MD, Schmitz O.

Eur J Endocrinol. 2004 Feb;150(2):207-14.PMID: 14763919 [PubMed - indexed for MEDLINE]Related articlesFree article