PubMed

Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain.

Yamamoto T, Kozikowski A, Zhou J, Neale JH.

Mol Pain. 2008 Aug 1;4:31.PMID: 18673570 [PubMed - indexed for MEDLINE]Related articlesFree article

Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats.

Yamamoto T, Saito O, Aoe T, Bartolozzi A, Sarva J, Zhou J, Kozikowski A, Wroblewska B, Bzdega T, Neale JH.

Eur J Neurosci. 2007 Jan;25(1):147-58.PMID: 17241276 [PubMed - indexed for MEDLINE]Related articles

Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model.

Yamamoto T, Hirasawa S, Wroblewska B, Grajkowska E, Zhou J, Kozikowski A, Wroblewski J, Neale JH.

Eur J Neurosci. 2004 Jul;20(2):483-94.PMID: 15233757 [PubMed - indexed for MEDLINE]Related articles

NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR.

Olszewski RT, Bukhari N, Zhou J, Kozikowski AP, Wroblewski JT, Shamimi-Noori S, Wroblewska B, Bzdega T, Vicini S, Barton FB, Neale JH.

J Neurochem. 2004 May;89(4):876-85.PMID: 15140187 [PubMed - indexed for MEDLINE]Related articles

Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors.

Olszewski RT, Wegorzewska MM, Monteiro AC, Krolikowski KA, Zhou J, Kozikowski AP, Long K, Mastropaolo J, Deutsch SI, Neale JH.

Biol Psychiatry. 2008 Jan 1;63(1):86-91. Epub 2007 Jun 27.PMID: 17597589 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration.

Nagel J, Belozertseva I, Greco S, Kashkin V, Malyshkin A, Jirgensons A, Shekunova E, Eilbacher B, Bespalov A, Danysz W.

Neuropharmacology. 2006 Dec;51(7-8):1163-71. Epub 2006 Aug 22.PMID: 16926034 [PubMed - indexed for MEDLINE]Related articles

NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.

Zhong C, Zhao X, Van KC, Bzdega T, Smyth A, Zhou J, Kozikowski AP, Jiang J, O'Connor WT, Berman RF, Neale JH, Lyeth BG.

J Neurochem. 2006 May;97(4):1015-25. Epub 2006 Apr 5.PMID: 16606367 [PubMed - indexed for MEDLINE]Related articles

The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia.

Neale JH, Olszewski RT, Gehl LM, Wroblewska B, Bzdega T.

Trends Pharmacol Sci. 2005 Sep;26(9):477-84. Review.PMID: 16055199 [PubMed - indexed for MEDLINE]Related articles

Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.

Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH.

J Med Chem. 2004 Mar 25;47(7):1729-38.PMID: 15027864 [PubMed - indexed for MEDLINE]Related articles

NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in rats.

Zhong C, Zhao X, Sarva J, Kozikowski A, Neale JH, Lyeth BG.

J Neurotrauma. 2005 Feb;22(2):266-76.PMID: 15716632 [PubMed - indexed for MEDLINE]Related articles

2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia.

Baslow MH, Dyakin VV, Nowak KL, Hungund BL, Guilfoyle DN.

J Mol Neurosci. 2005;26(1):1-15.PMID: 15968081 [PubMed - indexed for MEDLINE]Related articles

Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat.

Carpenter KJ, Sen S, Matthews EA, Flatters SL, Wozniak KM, Slusher BS, Dickenson AH.

Neuropeptides. 2003 Oct;37(5):298-306.PMID: 14607107 [PubMed - indexed for MEDLINE]Related articles

Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR.

Fricker AC, Mok MH, de la Flor R, Shah AJ, Woolley M, Dawson LA, Kew JN.

Neuropharmacology. 2009 May-Jun;56(6-7):1060-7. Epub 2009 Mar 12.PMID: 19285517 [PubMed - indexed for MEDLINE]Related articles

N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes.

Wroblewska B, Santi MR, Neale JH.

Glia. 1998 Oct;24(2):172-9.PMID: 9728763 [PubMed - indexed for MEDLINE]Related articles

N-Acetylated alpha-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin.

Thomas AG, Vornov JJ, Olkowski JL, Merion AT, Slusher BS.

J Pharmacol Exp Ther. 2000 Oct;295(1):16-22.PMID: 10991955 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3.

Berent-Spillson A, Robinson AM, Golovoy D, Slusher B, Rojas C, Russell JW.

J Neurochem. 2004 Apr;89(1):90-9.PMID: 15030392 [PubMed - indexed for MEDLINE]Related articles

N-acetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant nerve fiber.

Gafurov B, Urazaev AK, Grossfeld RM, Lieberman EM.

Neuroscience. 2001;106(1):227-35.PMID: 11564432 [PubMed - indexed for MEDLINE]Related articles

The regional distribution of N-acetylaspartylglutamate (NAAG) and peptidase activity against NAAG in the rat nervous system.

Fuhrman S, Palkovits M, Cassidy M, Neale JH.

J Neurochem. 1994 Jan;62(1):275-81.PMID: 8263527 [PubMed - indexed for MEDLINE]Related articles

N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system.

Neale JH, Bzdega T, Wroblewska B.

J Neurochem. 2000 Aug;75(2):443-52. Review.PMID: 10899918 [PubMed - indexed for MEDLINE]Related articles

Neuroprotection afforded by NAAG and NAALADase inhibition requires glial cells and metabotropic glutamate receptor activation.

Thomas AG, Olkowski JL, Slusher BS.

Eur J Pharmacol. 2001 Aug 24;426(1-2):35-8.PMID: 11525768 [PubMed - indexed for MEDLINE]Related articles