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    Results: 1 to 20 of 108

    1.

    Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance.

    Wong WP, Scott DW, Chuang CL, Zhang S, Liu H, Ferreira A, Saafi EL, Choong YS, Cooper GJ.

    Diabetes. 2008 Oct;57(10):2737-44. Epub 2008 Jul 15.PMID: 18633116 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

    Janson J, Soeller WC, Roche PC, Nelson RT, Torchia AJ, Kreutter DK, Butler PC.

    Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7283-8.PMID: 8692984 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.

    Hull RL, Andrikopoulos S, Verchere CB, Vidal J, Wang F, Cnop M, Prigeon RL, Kahn SE.

    Diabetes. 2003 Feb;52(2):372-9.PMID: 12540610 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

    Butler AE, Janson J, Soeller WC, Butler PC.

    Diabetes. 2003 Sep;52(9):2304-14.PMID: 12941770 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia.

    Höppener JW, Verbeek JS, de Koning EJ, Oosterwijk C, van Hulst KL, Visser-Vernooy HJ, Hofhuis FM, van Gaalen S, Berends MJ, Hackeng WH, et al.

    Diabetologia. 1993 Dec;36(12):1258-65.PMID: 8307253 [PubMed - indexed for MEDLINE]Related articles

    6.

    Formation of islet amyloid fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin.

    Yagui K, Yamaguchi T, Kanatsuka A, Shimada F, Huang CI, Tokuyama Y, Ohsawa H, Yamamura K, Miyazaki J, Mikata A, et al.

    Eur J Endocrinol. 1995 Apr;132(4):487-96.PMID: 7711888 [PubMed - indexed for MEDLINE]Related articles

    7.

    DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide.

    Ahrén B, Winzell MS, Wierup N, Sundler F, Burkey B, Hughes TE.

    Regul Pept. 2007 Oct 4;143(1-3):97-103. Epub 2007 Apr 11.PMID: 17482289 [PubMed - indexed for MEDLINE]Related articles

    8.

    Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model.

    Höppener JW, Oosterwijk C, Nieuwenhuis MG, Posthuma G, Thijssen JH, Vroom TM, Ahrén B, Lips CJ.

    Diabetologia. 1999 Apr;42(4):427-34.PMID: 10230646 [PubMed - indexed for MEDLINE]Related articles

    9.

    An in vitro model of early islet amyloid polypeptide (IAPP) fibrillogenesis using human IAPP-transgenic mouse islets.

    Henson MS, Buman BL, Jordan K, Rahrmann EP, Hardy RM, Johnson KH, O'Brien TD.

    Amyloid. 2006 Dec;13(4):250-9.PMID: 17107885 [PubMed - indexed for MEDLINE]Related articles

    10.

    Expression of human islet amyloid polypeptide/amylin impairs insulin secretion in mouse pancreatic beta cells.

    Tokuyama T, Yagui K, Yamaguchi T, Huang CI, Kuramoto N, Shimada F, Miyazaki J, Horie H, Saito Y, Makino H, Kanatsuka A.

    Metabolism. 1997 Sep;46(9):1044-51.PMID: 9284894 [PubMed - indexed for MEDLINE]Related articles

    11.

    beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

    Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

    Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

    Verchere CB, D'Alessio DA, Palmiter RD, Weir GC, Bonner-Weir S, Baskin DG, Kahn SE.

    Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3492-6.PMID: 8622964 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.

    D'Alessio DA, Verchere CB, Kahn SE, Hoagland V, Baskin DG, Palmiter RD, Ensinck JW.

    Diabetes. 1994 Dec;43(12):1457-61.PMID: 7958499 [PubMed - indexed for MEDLINE]Related articles

    14.

    [Construction of transgenic mouse system expressing human islet amyloid polypeptide (IAPP)/amylin]

    Yagui K, Kanatsuka A, Makino H.

    Nippon Rinsho. 1994 Oct;52(10):2746-50. Review. Japanese. PMID: 7983808 [PubMed - indexed for MEDLINE]Related articles

    15.

    Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

    de Koning EJ, Morris ER, Hofhuis FM, Posthuma G, Höppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS.

    Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8467-71.PMID: 8078905 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Postnatally disturbed pancreatic islet cell distribution in human islet amyloid polypeptide transgenic mice.

    Wong HY, Ahrén B, Lips CJ, Höppener JW, Sundler F.

    Regul Pept. 2003 May 15;113(1-3):89-94.PMID: 12686466 [PubMed - indexed for MEDLINE]Related articles

    17.

    Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets.

    Udayasankar J, Kodama K, Hull RL, Zraika S, Aston-Mourney K, Subramanian SL, Tong J, Faulenbach MV, Vidal J, Kahn SE.

    Diabetologia. 2009 Jan;52(1):145-53. Epub 2008 Nov 11.PMID: 19002432 [PubMed - indexed for MEDLINE]Related articles

    18.

    Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle.

    Cooper GJ, Leighton B, Dimitriadis GD, Parry-Billings M, Kowalchuk JM, Howland K, Rothbard JB, Willis AC, Reid KB.

    Proc Natl Acad Sci U S A. 1988 Oct;85(20):7763-6.PMID: 3051005 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes.

    Kahn SE, Andrikopoulos S, Verchere CB, Wang F, Hull RL, Vidal J.

    Diabetologia. 2000 Oct;43(10):1309-12.PMID: 11079750 [PubMed - indexed for MEDLINE]Related articles

    20.

    Molecular physiology of the islet amyloid polypeptide (IAPP)/amylin gene in man, rat, and transgenic mice.

    Höppener JW, Oosterwijk C, van Hulst KL, Verbeek JS, Capel PJ, de Koning EJ, Clark A, Jansz HS, Lips CJ.

    J Cell Biochem. 1994;55 Suppl:39-53. Review.PMID: 7929617 [PubMed - indexed for MEDLINE]Related articles

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