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    Results: 1 to 20 of 139

    1.

    Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.

    Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI.

    Diabetes. 2008 Oct;57(10):2644-51. Epub 2008 Jul 15.PMID: 18633112 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity.

    Araújo EP, De Souza CT, Gasparetti AL, Ueno M, Boschero AC, Saad MJ, Velloso LA.

    Endocrinology. 2005 Mar;146(3):1428-37. Epub 2004 Nov 18.PMID: 15550510 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation.

    Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky JM.

    J Clin Endocrinol Metab. 2002 Jan;87(1):226-34.PMID: 11788651 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    PKC-theta knockout mice are protected from fat-induced insulin resistance.

    Kim JK, Fillmore JJ, Sunshine MJ, Albrecht B, Higashimori T, Kim DW, Liu ZX, Soos TJ, Cline GW, O'Brien WR, Littman DR, Shulman GI.

    J Clin Invest. 2004 Sep;114(6):823-7.PMID: 15372106 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKKalpha/beta phosphorylation and decreases PI-3 kinase activity in muscle.

    Yaspelkis BB 3rd, Kvasha IA, Figueroa TY.

    Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1709-15. Epub 2009 Apr 22.PMID: 19386987 [PubMed - indexed for MEDLINE]Related articles

    6.

    Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells.

    Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schaüble M, Häring HU, Schleicher ED.

    J Biol Chem. 2006 Mar 17;281(11):7060-7. Epub 2006 Jan 17.PMID: 16418171 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells.

    Hribal ML, Federici M, Porzio O, Lauro D, Borboni P, Accili D, Lauro R, Sesti G.

    J Clin Endocrinol Metab. 2000 May;85(5):2004-13.PMID: 10843189 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.

    Park E, Wong V, Guan X, Oprescu AI, Giacca A.

    J Endocrinol. 2007 Nov;195(2):323-31.PMID: 17951543 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    [Effects of insulin receptor substrate-1 and its serine phosphorylation and tyrosine phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis: experiment with rats]

    Yan XW, Li WQ, Wang XD, Li JS, Li N.

    Zhonghua Yi Xue Za Zhi. 2006 Nov 7;86(41):2922-7. Chinese. PMID: 17288791 [PubMed - indexed for MEDLINE]Related articles

    10.

    Calorie restriction increases insulin-stimulated glucose transport in skeletal muscle from IRS-1 knockout mice.

    Gazdag AC, Dumke CL, Kahn CR, Cartee GD.

    Diabetes. 1999 Oct;48(10):1930-6.PMID: 10512356 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected].

    Storgaard H, Song XM, Jensen CB, Madsbad S, Björnholm M, Vaag A, Zierath JR.

    Diabetes. 2001 Dec;50(12):2770-8. Erratum in: Diabetes 2002 Feb;51(2):552. PMID: 11723060 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo.

    Neschen S, Katterle Y, Richter J, Augustin R, Scherneck S, Mirhashemi F, Schürmann A, Joost HG, Klaus S.

    Physiol Genomics. 2008 May 13;33(3):333-40. Epub 2008 Mar 18.PMID: 18349383 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.

    Fujii N, Ho RC, Manabe Y, Jessen N, Toyoda T, Holland WL, Summers SA, Hirshman MF, Goodyear LJ.

    Diabetes. 2008 Nov;57(11):2958-66. Epub 2008 Aug 26.PMID: 18728234 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities.

    Tremblay F, Lavigne C, Jacques H, Marette A.

    Diabetes. 2001 Aug;50(8):1901-10.PMID: 11473054 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.

    Storgaard H, Jensen CB, Björnholm M, Song XM, Madsbad S, Zierath JR, Vaag AA.

    J Clin Endocrinol Metab. 2004 Mar;89(3):1301-11.PMID: 15001626 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

    Kim YB, Zhu JS, Zierath JR, Shen HQ, Baron AD, Kahn BB.

    Diabetes. 1999 Feb;48(2):310-20.PMID: 10334307 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.

    Morris DL, Cho KW, Zhou Y, Rui L.

    Diabetes. 2009 Sep;58(9):2039-47. Epub 2009 Jun 19.PMID: 19542202 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus.

    Hartman ME, O'Connor JC, Godbout JP, Minor KD, Mazzocco VR, Freund GG.

    J Biol Chem. 2004 Jul 2;279(27):28045-50. Epub 2004 Apr 27.PMID: 15123681 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.

    Liu YF, Herschkovitz A, Boura-Halfon S, Ronen D, Paz K, Leroith D, Zick Y.

    Mol Cell Biol. 2004 Nov;24(21):9668-81.PMID: 15485932 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.

    Liu X, Liu M, Zhang J, Bai X, Ramos F, Van Remmen H, Richardson A, Liu FY, Dong LQ, Liu F.

    Am J Physiol Endocrinol Metab. 2009 May;296(5):E1067-75. Epub 2009 Feb 24.PMID: 19240254 [PubMed - indexed for MEDLINE]Related articles

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