PubMed

Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction.

Lovis P, Roggli E, Laybutt DR, Gattesco S, Yang JY, Widmann C, Abderrahmani A, Regazzi R.

Diabetes. 2008 Oct;57(10):2728-36. Epub 2008 Jul 15.PMID: 18633110 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.

Fontés G, Semache M, Hagman DK, Tremblay C, Shah R, Rhodes CJ, Rutter J, Poitout V.

Diabetes. 2009 Sep;58(9):2048-58. Epub 2009 Jun 5.PMID: 19502418 [PubMed - indexed for MEDLINE]Related articlesFree article

miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells.

El Ouaamari A, Baroukh N, Martens GA, Lebrun P, Pipeleers D, van Obberghen E.

Diabetes. 2008 Oct;57(10):2708-17. Epub 2008 Jun 30.PMID: 18591395 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

Metabolism. 2002 Oct;51(10):1340-7.PMID: 12370856 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.

Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N.

Diabetes. 2008 Sep;57(9):2382-92. Epub 2008 May 5.PMID: 18458149 [PubMed - indexed for MEDLINE]Related articlesFree article

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.

Zhou YP, Grill V.

J Clin Endocrinol Metab. 1995 May;80(5):1584-90.PMID: 7745004 [PubMed - indexed for MEDLINE]Related articles

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids.

Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V.

Diabetes. 2001 Feb;50(2):315-21.PMID: 11272142 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic palmitate exposure inhibits AMPKalpha and decreases glucose-stimulated insulin secretion from beta-cells: modulation by fenofibrate.

Sun Y, Ren M, Gao GQ, Gong B, Xin W, Guo H, Zhang XJ, Gao L, Zhao JJ.

Acta Pharmacol Sin. 2008 Apr;29(4):443-50.PMID: 18358090 [PubMed - indexed for MEDLINE]Related articlesFree article

Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.

Costes S, Vandewalle B, Tourrel-Cuzin C, Broca C, Linck N, Bertrand G, Kerr-Conte J, Portha B, Pattou F, Bockaert J, Dalle S.

Diabetes. 2009 May;58(5):1105-15. Epub 2009 Feb 17.PMID: 19223597 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets.

Marselli L, Trincavelli L, Santangelo C, Lupi R, Del Guerra S, Boggi U, Falleni A, Gremigni V, Mosca F, Martini C, Dotta F, Di Mario U, Del Prato S, Marchetti P.

Eur J Endocrinol. 2004 Aug;151(2):207-14.PMID: 15296476 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

Wente W, Efanov AM, Brenner M, Kharitonenkov A, Köster A, Sandusky GE, Sewing S, Treinies I, Zitzer H, Gromada J.

Diabetes. 2006 Sep;55(9):2470-8.PMID: 16936195 [PubMed - indexed for MEDLINE]Related articlesFree article

Diazoxide-induced beta-cell rest reduces endoplasmic reticulum stress in lipotoxic beta-cells.

Sargsyan E, Ortsäter H, Thorn K, Bergsten P.

J Endocrinol. 2008 Oct;199(1):41-50. Epub 2008 Jul 21.PMID: 18644846 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G.

PLoS One. 2009;4(3):e4954. Epub 2009 Mar 23.PMID: 19305497 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity.

Pagliassotti MJ, Wei Y, Wang D.

Endocrinology. 2007 Jul;148(7):3338-45. Epub 2007 Apr 12.PMID: 17431009 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line.

Sarkar SA, Kutlu B, Velmurugan K, Kizaka-Kondoh S, Lee CE, Wong R, Valentine A, Davidson HW, Hutton JC, Pugazhenthi S.

Diabetologia. 2009 Jun;52(6):1092-101. Epub 2009 Apr 3.PMID: 19343319 [PubMed - indexed for MEDLINE]Related articles

Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration.

Jacqueminet S, Briaud I, Rouault C, Reach G, Poitout V.

Metabolism. 2000 Apr;49(4):532-6.PMID: 10778881 [PubMed - indexed for MEDLINE]Related articles

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes.

Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ.

Diabetologia. 2007 Apr;50(4):752-63. Epub 2007 Feb 1.PMID: 17268797 [PubMed - indexed for MEDLINE]Related articles

The role of phosphoinositide 3-kinase/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo.

Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH.

Diabetes. 2006 Jun;55(6):1614-24.PMID: 16731823 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation.

Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, Van de Casteele M.

Free Radic Biol Med. 2007 Jan 1;42(1):64-78. Epub 2006 Sep 27.PMID: 17157194 [PubMed - indexed for MEDLINE]Related articles