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    Results: 1 to 20 of 108

    1.

    Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

    Lango H; UK Type 2 Diabetes Genetics Consortium, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN.

    Diabetes. 2008 Nov;57(11):3129-35. Epub 2008 Jun 30.PMID: 18591388 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction.

    Sparsø T, Grarup N, Andreasen C, Albrechtsen A, Holmkvist J, Andersen G, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T, Pedersen O.

    Diabetologia. 2009 Jul;52(7):1308-14. Epub 2009 Apr 29.PMID: 19404609 [PubMed - indexed for MEDLINE]Related articles

    3.

    Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.

    van Hoek M, Dehghan A, Witteman JC, van Duijn CM, Uitterlinden AG, Oostra BA, Hofman A, Sijbrands EJ, Janssens AC.

    Diabetes. 2008 Nov;57(11):3122-8. Epub 2008 Aug 11.PMID: 18694974 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Clinical risk factors, DNA variants, and the development of type 2 diabetes.

    Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, Berglund G, Altshuler D, Nilsson P, Groop L.

    N Engl J Med. 2008 Nov 20;359(21):2220-32.PMID: 19020324 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.

    Weedon MN, McCarthy MI, Hitman G, Walker M, Groves CJ, Zeggini E, Rayner NW, Shields B, Owen KR, Hattersley AT, Frayling TM.

    PLoS Med. 2006 Oct;3(10):e374.PMID: 17020404 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry.

    Cornelis MC, Qi L, Zhang C, Kraft P, Manson J, Cai T, Hunter DJ, Hu FB.

    Ann Intern Med. 2009 Apr 21;150(8):541-50.PMID: 19380854 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.

    Chandak GR, Janipalli CS, Bhaskar S, Kulkarni SR, Mohankrishna P, Hattersley AT, Frayling TM, Yajnik CS.

    Diabetologia. 2007 Jan;50(1):63-7. Epub 2006 Nov 9.PMID: 17093941 [PubMed - indexed for MEDLINE]Related articles

    8.

    Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

    Ng MC, Park KS, Oh B, Tam CH, Cho YM, Shin HD, Lam VK, Ma RC, So WY, Cho YS, Kim HL, Lee HK, Chan JC, Cho NH.

    Diabetes. 2008 Aug;57(8):2226-33. Epub 2008 May 9.PMID: 18469204 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.

    Sanghera DK, Ortega L, Han S, Singh J, Ralhan SK, Wander GS, Mehra NK, Mulvihill JJ, Ferrell RE, Nath SK, Kamboh MI.

    BMC Med Genet. 2008 Jul 3;9:59.PMID: 18598350 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.

    Rong R, Hanson RL, Ortiz D, Wiedrich C, Kobes S, Knowler WC, Bogardus C, Baier LJ.

    Diabetes. 2009 Feb;58(2):478-88. Epub 2008 Nov 13.PMID: 19008344 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study.

    Lin X, Song K, Lim N, Yuan X, Johnson T, Abderrahmani A, Vollenweider P, Stirnadel H, Sundseth SS, Lai E, Burns DK, Middleton LT, Roses AD, Matthews PM, Waeber G, Cardon L, Waterworth DM, Mooser V.

    Diabetologia. 2009 Apr;52(4):600-8. Epub 2009 Jan 13.PMID: 19139842 [PubMed - indexed for MEDLINE]Related articles

    12.

    Beta2-adrenergic receptor and UCP3 variants modulate the relationship between age and type 2 diabetes mellitus.

    Pinelli M, Giacchetti M, Acquaviva F, Cocozza S, Donnarumma G, Lapice E, Riccardi G, Romano G, Vaccaro O, Monticelli A.

    BMC Med Genet. 2006 Dec 6;7:85.PMID: 17150099 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Common type 2 diabetes risk gene variants associate with gestational diabetes.

    Lauenborg J, Grarup N, Damm P, Borch-Johnsen K, Jørgensen T, Pedersen O, Hansen T.

    J Clin Endocrinol Metab. 2009 Jan;94(1):145-50. Epub 2008 Nov 4.PMID: 18984664 [PubMed - indexed for MEDLINE]Related articles

    14.

    Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

    Wu Y, Li H, Loos RJ, Yu Z, Ye X, Chen L, Pan A, Hu FB, Lin X.

    Diabetes. 2008 Oct;57(10):2834-42. Epub 2008 Jul 15.PMID: 18633108 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.

    Lewis JP, Palmer ND, Hicks PJ, Sale MM, Langefeld CD, Freedman BI, Divers J, Bowden DW.

    Diabetes. 2008 Aug;57(8):2220-5. Epub 2008 Apr 28.PMID: 18443202 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.

    Rees SD, Bellary S, Britten AC, O'Hare JP, Kumar S, Barnett AH, Kelly MA.

    BMC Med Genet. 2008 Feb 21;9:8.PMID: 18291022 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population.

    Marquezine GF, Pereira AC, Sousa AG, Mill JG, Hueb WA, Krieger JE.

    BMC Med Genet. 2008 Dec 4;9:106.PMID: 19055834 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

    Cauchi S, Stutzmann F, Cavalcanti-Proença C, Durand E, Pouta A, Hartikainen AL, Marre M, Vol S, Tammelin T, Laitinen J, Gonzalez-Izquierdo A, Blakemore AI, Elliott P, Meyre D, Balkau B, Järvelin MR, Froguel P.

    J Mol Med. 2009 May;87(5):537-46. Epub 2009 Mar 3.PMID: 19255736 [PubMed - indexed for MEDLINE]Related articles

    19.

    Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

    Timpson NJ, Lindgren CM, Weedon MN, Randall J, Ouwehand WH, Strachan DP, Rayner NW, Walker M, Hitman GA, Doney AS, Palmer CN, Morris AD, Hattersley AT, Zeggini E, Frayling TM, McCarthy MI.

    Diabetes. 2009 Feb;58(2):505-10. Epub 2008 Dec 3.PMID: 19056611 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.

    Horikoshi M, Hara K, Ito C, Nagai R, Froguel P, Kadowaki T.

    Diabetologia. 2007 Apr;50(4):747-51. Epub 2007 Jan 24.PMID: 17245589 [PubMed - indexed for MEDLINE]Related articles

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