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    Results: 1 to 20 of 812

    1.

    Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells.

    Fandy TE, Shankar S, Srivastava RK.

    Mol Cancer. 2008 Jun 30;7:60.PMID: 18590557 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: sensitization by overexpression of second mitochondria-derived activator of caspase/direct IAP-binding protein with low pl (Smac/DIABLO).

    Ng CP, Bonavida B.

    Mol Cancer Ther. 2002 Oct;1(12):1051-8.PMID: 12481428 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells.

    Bockbrader KM, Tan M, Sun Y.

    Oncogene. 2005 Nov 10;24(49):7381-8.PMID: 16044155 [PubMed - indexed for MEDLINE]Related articles

    4.

    Transfection of Smac/DIABLO sensitizes drug-resistant tumor cells to TRAIL or paclitaxel-induced apoptosis in vitro.

    Mao HL, Liu PS, Zheng JF, Zhang PH, Zhou LG, Xin G, Liu C.

    Pharmacol Res. 2007 Dec;56(6):483-92. Epub 2007 Sep 15.PMID: 18029193 [PubMed - indexed for MEDLINE]Related articles

    5.

    Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis.

    Guo F, Nimmanapalli R, Paranawithana S, Wittman S, Griffin D, Bali P, O'Bryan E, Fumero C, Wang HG, Bhalla K.

    Blood. 2002 May 1;99(9):3419-26.PMID: 11964312 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by smac/DIABLO release from mitochondria.

    Zhang XD, Zhang XY, Gray CP, Nguyen T, Hersey P.

    Cancer Res. 2001 Oct 1;61(19):7339-48.PMID: 11585775 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    X-linked inhibitor regulating TRAIL-induced apoptosis in chemoresistant human primary glioblastoma cells.

    Roa WH, Chen H, Fulton D, Gulavita S, Shaw A, Th'ng J, Farr-Jones M, Moore R, Petruk K.

    Clin Invest Med. 2003 Oct;26(5):231-42.PMID: 14596484 [PubMed - indexed for MEDLINE]Related articles

    8.

    Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria.

    Nagy K, Székely-Szüts K, Izeradjene K, Douglas L, Tillman M, Barti-Juhász H, Dominici M, Spano C, Luca Cervo G, Conte P, Houghton JA, Mihalik R, Kopper L, Peták I.

    Pathol Oncol Res. 2006;12(3):133-42. Epub 2006 Sep 23.PMID: 16998592 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

    Fulda S, Wick W, Weller M, Debatin KM.

    Nat Med. 2002 Aug;8(8):808-15. Epub 2002 Jul 15.PMID: 12118245 [PubMed - indexed for MEDLINE]Related articles

    10.

    The essential role of the mitochondria-dependent death-signaling cascade in chemotherapy-induced potentiation of Apo2L/TRAIL cytotoxicity in cultured thoracic cancer cells: amplified caspase 8 is indispensable for combination-mediated massive cell death.

    Nguyen DM, Yeow WS, Ziauddin MF, Baras A, Tsai W, Reddy RM, Chua A, Cole GW Jr, Schrump DS.

    Cancer J. 2006 Jul-Aug;12(4):257-73.PMID: 16925970 [PubMed - indexed for MEDLINE]Related articles

    11.

    Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells.

    Mori T, Doi R, Kida A, Nagai K, Kami K, Ito D, Toyoda E, Kawaguchi Y, Uemoto S.

    J Surg Res. 2007 Oct;142(2):281-6. Epub 2007 Jul 19.PMID: 17640673 [PubMed - indexed for MEDLINE]Related articles

    12.

    MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release.

    Mohr A, Büneker C, Gough RP, Zwacka RM.

    Oncogene. 2008 Jan 31;27(6):763-74. Epub 2007 Jul 23.PMID: 17653087 [PubMed - indexed for MEDLINE]Related articles

    13.

    A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB.

    Dai Y, Liu M, Tang W, Li Y, Lian J, Lawrence TS, Xu L.

    BMC Cancer. 2009 Nov 6;9:392.PMID: 19895686 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells.

    Petrucci E, Pasquini L, Petronelli A, Saulle E, Mariani G, Riccioni R, Biffoni M, Ferretti G, Benedetti-Panici P, Cognetti F, Scambia G, Humphreys R, Peschle C, Testa U.

    Gynecol Oncol. 2007 May;105(2):481-92. Epub 2007 Feb 9.PMID: 17292950 [PubMed - indexed for MEDLINE]Related articles

    15.

    Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells.

    Sinicrope FA, Penington RC, Tang XM.

    Clin Cancer Res. 2004 Dec 15;10(24):8284-92.PMID: 15623604 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria.

    Zhang XD, Borrow JM, Zhang XY, Nguyen T, Hersey P.

    Oncogene. 2003 May 15;22(19):2869-81.PMID: 12771938 [PubMed - indexed for MEDLINE]Related articles

    17.

    Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo.

    Singh TR, Shankar S, Chen X, Asim M, Srivastava RK.

    Cancer Res. 2003 Sep 1;63(17):5390-400.PMID: 14500373 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF.

    Huerta S, Heinzerling JH, Anguiano-Hernandez YM, Huerta-Yepez S, Lin J, Chen D, Bonavida B, Livingston EH.

    J Surg Res. 2007 Sep;142(1):184-94. Epub 2007 Jul 2.PMID: 17603079 [PubMed - indexed for MEDLINE]Related articles

    19.

    Impaired kinetics of Bax-GFP and Smac/DIABLO-GFP in caspase-8- and bid-silenced and Bcl-2 overexpressed breast cancer MCF-7 cells exposed to camptothecin.

    Górka M, Lamparska-Przybysz M, Motyl T.

    Cell Mol Biol (Noisy-le-grand). 2007 Jan 21;52 Suppl:OL915-22.PMID: 17666167 [PubMed - indexed for MEDLINE]Related articles

    20.

    Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines.

    Izeradjene K, Douglas L, Tillman DM, Delaney AB, Houghton JA.

    Cancer Res. 2005 Aug 15;65(16):7436-45.PMID: 16103097 [PubMed - indexed for MEDLINE]Related articlesFree article

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