PubMed

The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.

Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V.

Diabetes. 2008 Sep;57(9):2432-7. Epub 2008 Jun 16. Erratum in: Diabetes. 2008 Nov;57(11):3166. PMID: 18559658 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice.

Tan CP, Feng Y, Zhou YP, Eiermann GJ, Petrov A, Zhou C, Lin S, Salituro G, Meinke P, Mosley R, Akiyama TE, Einstein M, Kumar S, Berger JP, Mills SG, Thornberry NA, Yang L, Howard AD.

Diabetes. 2008 Aug;57(8):2211-9. Epub 2008 May 13.PMID: 18477808 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.

Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y.

Diabetes. 2009 May;58(5):1067-76. Erratum in: Diabetes. 2009 Jul;58(7):1721. PMID: 19401434 [PubMed - indexed for MEDLINE]Related articlesFree article

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, Luo J, Lin DC, Poitout V.

Diabetes. 2007 Apr;56(4):1087-94.PMID: 17395749 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease.

Lan H, Hoos LM, Liu L, Tetzloff G, Hu W, Abbondanzo SJ, Vassileva G, Gustafson EL, Hedrick JA, Davis HR.

Diabetes. 2008 Nov;57(11):2999-3006. Epub 2008 Aug 4.PMID: 18678612 [PubMed - indexed for MEDLINE]Related articlesFree article

The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: investigations using GPR40-knockout mice.

Brownlie R, Mayers RM, Pierce JA, Marley AE, Smith DM.

Biochem Soc Trans. 2008 Oct;36(Pt 5):950-4. Review.PMID: 18793167 [PubMed - indexed for MEDLINE]Related articles

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse.

Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H.

Cell Metab. 2005 Apr;1(4):245-58.PMID: 16054069 [PubMed - indexed for MEDLINE]Related articles

Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.

Edfalk S, Steneberg P, Edlund H.

Diabetes. 2008 Sep;57(9):2280-7. Epub 2008 Jun 2.PMID: 18519800 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat.

Doshi LS, Brahma MK, Sayyed SG, Dixit AV, Chandak PG, Pamidiboina V, Motiwala HF, Sharma SD, Nemmani KV.

Metabolism. 2009 Mar;58(3):333-43.PMID: 19217448 [PubMed - indexed for MEDLINE]Related articles

Disruption of G protein-coupled receptor 39 impairs insulin secretion in vivo.

Tremblay F, Richard AM, Will S, Syed J, Stedman N, Perreault M, Gimeno RE.

Endocrinology. 2009 Jun;150(6):2586-95. Epub 2009 Feb 12.PMID: 19213841 [PubMed - indexed for MEDLINE]Related articles

Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization.

Vettor R, Granzotto M, De Stefani D, Trevellin E, Rossato M, Farina MG, Milan G, Pilon C, Nigro A, Federspil G, Vigneri R, Vitiello L, Rizzuto R, Baratta R, Frittitta L.

J Clin Endocrinol Metab. 2008 Sep;93(9):3541-50. Epub 2008 Jun 26.PMID: 18583466 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice.

Gorman T, Hope DC, Brownlie R, Yu A, Gill D, Löfvenmark J, Wedin M, Mayers RM, Snaith MR, Smith DM.

Diabetes Obes Metab. 2008 Sep;10(10):885-97. Epub 2007 Nov 22.PMID: 18034843 [PubMed - indexed for MEDLINE]Related articles

Adipocyte metabolism in adipocyte fatty acid binding protein knockout mice (aP2-/-) after short-term high-fat feeding: functional compensation by the keratinocyte [correction of keritinocyte] fatty acid binding protein.

Shaughnessy S, Smith ER, Kodukula S, Storch J, Fried SK.

Diabetes. 2000 Jun;49(6):904-11. Erratum in: Diabetes 2000 Sep;49(9):1617. PMID: 10866041 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.

Schnell S, Schaefer M, Schöfl C.

Mol Cell Endocrinol. 2007 Jan 15;263(1-2):173-80. Epub 2006 Nov 13.PMID: 17101212 [PubMed - indexed for MEDLINE]Related articles

Overexpression of GPR40 in Pancreatic {beta}-Cells Augments Glucose Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice.

Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y.

Diabetes. 2009 Feb 19. [Epub ahead of print]PMID: 19208915 [PubMed - as supplied by publisher]Related articles

Temporal and dietary fat content-dependent islet adaptation to high-fat feeding-induced glucose intolerance in mice.

Winzell MS, Magnusson C, Ahrén B.

Metabolism. 2007 Jan;56(1):122-8.PMID: 17161234 [PubMed - indexed for MEDLINE]Related articles

Acute omega-3 fatty acid enrichment selectively reverses high-saturated fat feeding-induced insulin hypersecretion but does not improve peripheral insulin resistance.

Holness MJ, Smith ND, Greenwood GK, Sugden MC.

Diabetes. 2004 Feb;53 Suppl 1:S166-71.PMID: 14749283 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARalpha activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic beta-cell function in late pregnancy.

Holness MJ, Smith ND, Greenwood GK, Sugden MC.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1087-94. Epub 2006 Dec 12.PMID: 17164438 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced blood glucose levels, increased insulin levels and improved glucose tolerance in alpha2A-adrenoceptor knockout mice.

Savontaus E, Fagerholm V, Rahkonen O, Scheinin M.

Eur J Pharmacol. 2008 Jan 14;578(2-3):359-64. Epub 2007 Oct 2.PMID: 17964569 [PubMed - indexed for MEDLINE]Related articles

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet.

Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB, Wheeler MB.

Diabetes. 2002 Nov;51(11):3211-9.PMID: 12401712 [PubMed - indexed for MEDLINE]Related articlesFree article