PubMed

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.

Vaxillaire M, Cavalcanti-Proença C, Dechaume A, Tichet J, Marre M, Balkau B, Froguel P; DESIR Study Group.

Diabetes. 2008 Aug;57(8):2253-7. Epub 2008 Jun 12.PMID: 18556336 [PubMed - indexed for MEDLINE]Related articlesFree article

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.

Orho-Melander M, Melander O, Guiducci C, Perez-Martinez P, Corella D, Roos C, Tewhey R, Rieder MJ, Hall J, Abecasis G, Tai ES, Welch C, Arnett DK, Lyssenko V, Lindholm E, Saxena R, de Bakker PI, Burtt N, Voight BF, Hirschhorn JN, Tucker KL, Hedner T, Tuomi T, Isomaa B, Eriksson KF, Taskinen MR, Wahlstrand B, Hughes TE, Parnell LD, Lai CQ, Berglund G, Peltonen L, Vartiainen E, Jousilahti P, Havulinna AS, Salomaa V, Nilsson P, Groop L, Altshuler D, Ordovas JM, Kathiresan S.

Diabetes. 2008 Nov;57(11):3112-21. Epub 2008 Aug 4.PMID: 18678614 [PubMed - indexed for MEDLINE]Related articlesFree article

The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.

Sparsø T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AP, Nielsen AL, Albrechtsen A, Rasmussen SS, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T, Pedersen O.

Diabetologia. 2008 Jan;51(1):70-5. Epub 2007 Nov 16. Erratum in: Diabetologia. 2008 Feb;51(2):383. PMID: 18008060 [PubMed - indexed for MEDLINE]Related articles

Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.

Tam CH, Ma RC, So WY, Wang Y, Lam VK, Germer S, Martin M, Chan JC, Ng MC.

Diabetes. 2009 Mar;58(3):765-9. Epub 2008 Dec 10.PMID: 19073768 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study.

Vaxillaire M, Veslot J, Dina C, Proença C, Cauchi S, Charpentier G, Tichet J, Fumeron F, Marre M, Meyre D, Balkau B, Froguel P; DESIR Study Group.

Diabetes. 2008 Jan;57(1):244-54. Epub 2007 Oct 31.PMID: 17977958 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.

Qi Q, Wu Y, Li H, Loos RJ, Hu FB, Sun L, Lu L, Pan A, Liu C, Wu H, Chen L, Yu Z, Lin X.

Diabetologia. 2009 May;52(5):834-43. Epub 2009 Feb 25.PMID: 19241058 [PubMed - indexed for MEDLINE]Related articles

A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.

Rose CS, Ek J, Urhammer SA, Glümer C, Borch-Johnsen K, Jørgensen T, Pedersen O, Hansen T.

Diabetes. 2005 Oct;54(10):3026-31.PMID: 16186409 [PubMed - indexed for MEDLINE]Related articlesFree article

TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study.

Cauchi S, Meyre D, Choquet H, Dina C, Born C, Marre M, Balkau B, Froguel P; DESIR Study Group.

Diabetes. 2006 Nov;55(11):3189-92. Erratum in: Diabetes. 2006 Dec;55(12):3635. PMID: 17065361 [PubMed - indexed for MEDLINE]Related articlesFree article

AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects.

Andersen G, Burgdorf KS, Sparsø T, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O.

Diabetes. 2008 May;57(5):1427-32. Epub 2008 Mar 3.PMID: 18316360 [PubMed - indexed for MEDLINE]Related articlesFree article

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.

Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, Sparsø T, Holmkvist J, Marchand M, Delplanque J, Lobbens S, Rocheleau G, Durand E, De Graeve F, Chèvre JC, Borch-Johnsen K, Hartikainen AL, Ruokonen A, Tichet J, Marre M, Weill J, Heude B, Tauber M, Lemaire K, Schuit F, Elliott P, Jørgensen T, Charpentier G, Hadjadj S, Cauchi S, Vaxillaire M, Sladek R, Visvikis-Siest S, Balkau B, Lévy-Marchal C, Pattou F, Meyre D, Blakemore AI, Jarvelin MR, Walley AJ, Hansen T, Dina C, Pedersen O, Froguel P.

Nat Genet. 2009 Jan;41(1):89-94. Epub 2008 Dec 7.PMID: 19060909 [PubMed - indexed for MEDLINE]Related articles

Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.

Cauchi S, Proença C, Choquet H, Gaget S, De Graeve F, Marre M, Balkau B, Tichet J, Meyre D, Vaxillaire M, Froguel P; D.E.S.I.R. Study Group.

J Mol Med. 2008 Mar;86(3):341-8. Epub 2008 Jan 22.PMID: 18210030 [PubMed - indexed for MEDLINE]Related articles

The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study.

Jaziri R, Lobbens S, Aubert R, Péan F, Lahmidi S, Vaxillaire M, Porchay I, Bellili N, Tichet J, Balkau B, Froguel P, Marre M, Fumeron F; DESIR Study Group.

Diabetes. 2006 Apr;55(4):1157-62.PMID: 16567542 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study.

Fumeron F, Aubert R, Siddiq A, Betoulle D, Péan F, Hadjadj S, Tichet J, Wilpart E, Chesnier MC, Balkau B, Froguel P, Marre M; Epidemiologic Data on the Insulin Resistance Syndrome (DESIR) Study Group.

Diabetes. 2004 Apr;53(4):1150-7.PMID: 15047634 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.

Perez-Martinez P, Corella D, Shen J, Arnett DK, Yiannakouris N, Tai ES, Orho-Melander M, Tucker KL, Tsai M, Straka RJ, Province M, Kai CS, Perez-Jimenez F, Lai CQ, Lopez-Miranda J, Guillen M, Parnell LD, Borecki I, Kathiresan S, Ordovas JM.

Am J Clin Nutr. 2009 Jan;89(1):391-9. Epub 2008 Dec 3.PMID: 19056598 [PubMed - indexed for MEDLINE]Related articles

Variable effects of the APOC3-482C > T variant on insulin, glucose and triglyceride concentrations in different ethnic groups.

Waterworth DM, Talmud PJ, Humphries SE, Wicks PD, Sagnella GA, Strazzullo P, Alberti KG, Cook DG, Cappuccio FP.

Diabetologia. 2001 Feb;44(2):245-8.PMID: 11270684 [PubMed - indexed for MEDLINE]Related articles

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.

Beer NL, Tribble ND, McCulloch LJ, Roos C, Johnson PR, Orho-Melander M, Gloyn AL.

Hum Mol Genet. 2009 Nov 1;18(21):4081-8. Epub 2009 Jul 30.PMID: 19643913 [PubMed - in process]Related articlesFree article

G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.

Sparsø T, Bonnefond A, Andersson E, Bouatia-Naji N, Holmkvist J, Wegner L, Grarup N, Gjesing AP, Banasik K, Cavalcanti-Proença C, Marchand M, Vaxillaire M, Charpentier G, Jarvelin MR, Tichet J, Balkau B, Marre M, Lévy-Marchal C, Faerch K, Borch-Johnsen K, Jørgensen T, Madsbad S, Poulsen P, Vaag A, Dina C, Hansen T, Pedersen O, Froguel P.

Diabetes. 2009 Jun;58(6):1450-6. Epub 2009 Mar 26.PMID: 19324940 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.

Tan JT, Nurbaya S, Gardner D, Ye S, Tai ES, Ng DP.

Diabetes. 2009 Jun;58(6):1445-9. Epub 2009 Feb 27.PMID: 19252135 [PubMed - indexed for MEDLINE]Related articlesFree article

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.

Meyre D, Bouatia-Naji N, Vatin V, Veslot J, Samson C, Tichet J, Marre M, Balkau B, Froguel P.

Diabetologia. 2007 Oct;50(10):2090-6. Epub 2007 Aug 18.PMID: 17704904 [PubMed - indexed for MEDLINE]Related articles

Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study.

Shen H, Pollin TI, Damcott CM, McLenithan JC, Mitchell BD, Shuldiner AR.

Hum Genet. 2009 Oct;126(4):567-74. Epub 2009 Jun 13.PMID: 19526250 [PubMed - indexed for MEDLINE]Related articles