PubMed

Setting up non-commercial clinical trials takes too long in the UK: findings from a prospective study.

Hackshaw A, Farrant H, Bulley S, Seckl MJ, Ledermann JA.

J R Soc Med. 2008 Jun;101(6):299-304.PMID: 18515777 [PubMed - indexed for MEDLINE]Related articlesFree article

Research governance impediments to clinical trials: a retrospective survey.

Al-Shahi Salman R, Brock TM, Dennis MS, Sandercock PA, White PM, Warlow C.

J R Soc Med. 2007 Feb;100(2):101-4.PMID: 17277284 [PubMed - indexed for MEDLINE]Related articlesFree article

Implementing the UK Medical Research Council (MRC) RT01 trial (ISRCTN 47772397): methods and practicalities of a randomised controlled trial of conformal radiotherapy in men with localised prostate cancer.

Sydes MR, Stephens RJ, Moore AR, Aird EG, Bidmead AM, Fallowfield LJ, Graham J, Griffiths S, Mayles WP, McGuire A, Stanley S, Warrington AP, Dearnaley DP; RT01 collaborators.

Radiother Oncol. 2004 Aug;72(2):199-211.PMID: 15297138 [PubMed - indexed for MEDLINE]Related articles

[Obtaining medical ethical approval for a multicentre, randomised study: prospective evaluation of a ponderous process]

van Santvoort HC, Besselink MG, Gooszen HG.

Ned Tijdschr Geneeskd. 2008 Sep 20;152(38):2077-83. Dutch. PMID: 18837184 [PubMed - indexed for MEDLINE]Related articles

Variations in experience in obtaining local ethical approval for participation in a multi-centre study.

Maskell NA, Jones EL, Davies RJ; BTS/MRC MIST steering committee.

QJM. 2003 Apr;96(4):305-7.PMID: 12651975 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-commercial clinical trials of a medicinal product: can they survive the current process of research approvals in the UK?

Sheard L, Tompkins CN, Wright NM, Adams CE.

J Med Ethics. 2006 Jul;32(7):430-4. Review.PMID: 16816046 [PubMed - indexed for MEDLINE]Related articlesFree article

Recruitment to multicentre trials--lessons from UKCTOCS: descriptive study.

Menon U, Gentry-Maharaj A, Ryan A, Sharma A, Burnell M, Hallett R, Lewis S, Lopez A, Godfrey K, Oram D, Herod J, Williamson K, Seif M, Scott I, Mould T, Woolas R, Murdoch J, Dobbs S, Amso N, Leeson S, Cruickshank D, McGuire A, Campbell S, Fallowfield L, Skates S, Parmar M, Jacobs I.

BMJ. 2008 Nov 13;337:a2079. doi: 10.1136/bmj.a2079. Erratum in: BMJ. 2008;337:a2976. PMID: 19008269 [PubMed - indexed for MEDLINE]Related articlesFree article

The new system of review by multicentre research ethics committees: prospective study.

Tully J, Ninis N, Booy R, Viner R.

BMJ. 2000 Apr 29;320(7243):1179-82.PMID: 10784541 [PubMed - indexed for MEDLINE]Related articlesFree article

The Department of Health's research governance framework remains an impediment to multi-centre studies: findings from a national descriptive study.

Kielmann T, Tierney A, Porteous R, Huby G, Sheikh A, Pinnock H.

J R Soc Med. 2007 May;100(5):234-8.PMID: 17470931 [PubMed - indexed for MEDLINE]Related articlesFree article

Delays and diversity in the practice of local research ethics committees.

Ahmed AH, Nicholson KG.

J Med Ethics. 1996 Oct;22(5):263-6.PMID: 8910776 [PubMed - indexed for MEDLINE]Related articlesFree article

Adverse effects of a multicentre system for ethics approval on the progress of a prospective multicentre trial of cancer treatment: how many patients die waiting?

Christie DR, Gabriel GS, Dear K.

Intern Med J. 2007 Oct;37(10):680-6.PMID: 17894765 [PubMed - indexed for MEDLINE]Related articles

A case study evaluation of ethics review systems for multicentre clinical trials.

Hicks SC, James RE, Wong N, Tebbutt NC, Wilson K; Australasian Gastro-Intestinal Trials Group.

Med J Aust. 2009 Sep 7;191(5):280-2. Review.PMID: 19740053 [PubMed - indexed for MEDLINE]Related articles

The impact of the 'Clinical Trials' directive on the cost and conduct of non-commercial cancer trials in the UK.

Hearn J, Sullivan R.

Eur J Cancer. 2007 Jan;43(1):8-13. Epub 2006 Nov 21.PMID: 17118647 [PubMed - indexed for MEDLINE]Related articles

[Unnecessary delays in ethical approval of multicentre clinical trials]

Evers JL.

Ned Tijdschr Geneeskd. 2008 Sep 20;152(38):2062-4. Dutch. PMID: 18837181 [PubMed - indexed for MEDLINE]Related articles

Assessment of the ethical review process for non-pharmacological multicentre studies in Germany on the basis of a randomised surgical trial.

Seiler CM, Kellmeyer P, Kienle P, Büchler MW, Knaebel HP; INSECT Study Group.

J Med Ethics. 2007 Feb;33(2):113-8.PMID: 17264200 [PubMed - indexed for MEDLINE]Related articles

Research governance delays for a multicentre non-interventional study.

Mallick AA, O'Callaghan FJ.

J R Soc Med. 2009 May;102(5):195-8.PMID: 19417052 [PubMed - indexed for MEDLINE]Related articlesFree article

[Difficulties with conducting clinical trials in France]

Zannad F, Plétan Y.

Therapie. 2001 Jul-Aug;56(4):341-7. French. PMID: 11677850 [PubMed - indexed for MEDLINE]Related articles

Recruitment to multicentre trials: the impact of external influences.

Gillan MG, Ross S, Gilbert FJ, Grant AM, O'Dwyer PJ.

Health Bull (Edinb). 2000 May;58(3):229-34.PMID: 12813832 [PubMed - indexed for MEDLINE]Related articles

Trends in UK cancer trials: results from the UK Coordinating Committee for Cancer Research National Register of Cancer Trials.

Vale C, Stewart L, Tierney J; UK Coordinating Committee for Cancer Research National Register of Cancer.

Br J Cancer. 2005 Mar 14;92(5):811-4.PMID: 15756251 [PubMed - indexed for MEDLINE]Related articlesFree article

[Mission and tasks of the Coordination Centres for Clinical Trials]

Luntz SP, Gorbauch T, Schröder B, Seibert-Grafe M.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2009 Apr;52(4):444-50. German. PMID: 19263026 [PubMed - indexed for MEDLINE]Related articles