PubMed

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease.

Jin JJ, Kim HD, Maxwell JA, Li L, Fukuchi K.

J Neuroinflammation. 2008 May 29;5:23.PMID: 18510752 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of toll-like receptor signalling in Abeta uptake and clearance.

Tahara K, Kim HD, Jin JJ, Maxwell JA, Li L, Fukuchi K.

Brain. 2006 Nov;129(Pt 11):3006-19. Epub 2006 Sep 19.PMID: 16984903 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease.

Mori T, Koyama N, Arendash GW, Horikoshi-Sakuraba Y, Tan J, Town T.

Glia. 2010 Feb;58(3):300-14.PMID: 19705461 [PubMed - indexed for MEDLINE]Related articlesFree article

Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain.

Lee J, Chan SL, Mattson MP.

Neuromolecular Med. 2002;2(1):29-45.PMID: 12230303 [PubMed - indexed for MEDLINE]Related articles

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.

Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T.

Am J Pathol. 2007 Feb;170(2):680-92.PMID: 17255335 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice.

Frank S, Copanaki E, Burbach GJ, Müller UC, Deller T.

Neurosci Lett. 2009 Mar 27;453(1):41-4. Epub 2009 Feb 4.PMID: 19429012 [PubMed - indexed for MEDLINE]Related articles

Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease.

Manczak M, Mao P, Nakamura K, Bebbington C, Park B, Reddy PH.

Hum Mol Genet. 2009 Oct 15;18(20):3876-93. Epub 2009 Jul 19.PMID: 19617638 [PubMed - indexed for MEDLINE]Related articles

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice.

Maier M, Peng Y, Jiang L, Seabrook TJ, Carroll MC, Lemere CA.

J Neurosci. 2008 Jun 18;28(25):6333-41.PMID: 18562603 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K.

Am J Pathol. 2001 Apr;158(4):1345-54.PMID: 11290552 [PubMed - indexed for MEDLINE]Related articlesFree article

MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.

Culbert AA, Skaper SD, Howlett DR, Evans NA, Facci L, Soden PE, Seymour ZM, Guillot F, Gaestel M, Richardson JC.

J Biol Chem. 2006 Aug 18;281(33):23658-67. Epub 2006 Jun 14.PMID: 16774924 [PubMed - indexed for MEDLINE]Related articlesFree article

Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease.

Richard KL, Filali M, Préfontaine P, Rivest S.

J Neurosci. 2008 May 28;28(22):5784-93.PMID: 18509040 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology.

Mehlhorn G, Hollborn M, Schliebs R.

Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):423-31.PMID: 10817926 [PubMed - indexed for MEDLINE]Related articles

Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease.

Ruan L, Kang Z, Pei G, Le Y.

Curr Alzheimer Res. 2009 Dec;6(6):531-40.PMID: 19747158 [PubMed - indexed for MEDLINE]Related articles

Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease.

Jana M, Palencia CA, Pahan K.

J Immunol. 2008 Nov 15;181(10):7254-62.PMID: 18981147 [PubMed - indexed for MEDLINE]Related articlesFree article

CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase.

Tan J, Town T, Mori T, Wu Y, Saxe M, Crawford F, Mullan M.

J Neurosci. 2000 Oct 15;20(20):7587-94.PMID: 11027218 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology.

Apelt J, Schliebs R.

Brain Res. 2001 Mar 9;894(1):21-30.PMID: 11245811 [PubMed - indexed for MEDLINE]Related articles

Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice.

Abbas N, Bednar I, Mix E, Marie S, Paterson D, Ljungberg A, Morris C, Winblad B, Nordberg A, Zhu J.

J Neuroimmunol. 2002 May;126(1-2):50-7.PMID: 12020956 [PubMed - indexed for MEDLINE]Related articles

Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease.

Nakamura K, Ohya W, Funakoshi H, Sakaguchi G, Kato A, Takeda M, Kudo T, Nakamura T.

J Neurosci Res. 2006 Sep;84(4):874-90.PMID: 16868960 [PubMed - indexed for MEDLINE]Related articles

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs.

Olson JK, Miller SD.

J Immunol. 2004 Sep 15;173(6):3916-24.PMID: 15356140 [PubMed - indexed for MEDLINE]Related articlesFree article

Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice.

Hickman SE, Allison EK, El Khoury J.

J Neurosci. 2008 Aug 13;28(33):8354-60.PMID: 18701698 [PubMed - indexed for MEDLINE]Related articlesFree article