PubMed

CD28/CD154 blockade prevents autoimmune diabetes by inducing nondeletional tolerance after effector t-cell inhibition and regulatory T-cell expansion.

Rigby MR, Trexler AM, Pearson TC, Larsen CP.

Diabetes. 2008 Oct;57(10):2672-83. Epub 2008 May 20.PMID: 18492787 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms.

Demirci G, Strom TB, Li XC.

J Immunol. 2003 Oct 1;171(7):3878-85.PMID: 14500690 [PubMed - indexed for MEDLINE]Related articlesFree article

Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells.

Gaudreau S, Guindi C, Ménard M, Besin G, Dupuis G, Amrani A.

J Immunol. 2007 Sep 15;179(6):3638-47.PMID: 17785799 [PubMed - indexed for MEDLINE]Related articlesFree article

Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse.

Nanji SA, Hancock WW, Luo B, Schur CD, Pawlick RL, Zhu LF, Anderson CC, Shapiro AM.

Diabetes. 2006 Jan;55(1):27-33.PMID: 16380473 [PubMed - indexed for MEDLINE]Related articlesFree article

Transfusion of apoptotic beta-cells induces immune tolerance to beta-cell antigens and prevents type 1 diabetes in NOD mice.

Xia CQ, Peng R, Qiu Y, Annamalai M, Gordon D, Clare-Salzler MJ.

Diabetes. 2007 Aug;56(8):2116-23. Epub 2007 May 11.PMID: 17496235 [PubMed - indexed for MEDLINE]Related articlesFree article

Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells.

Madec AM, Mallone R, Afonso G, Abou Mrad E, Mesnier A, Eljaafari A, Thivolet C.

Diabetologia. 2009 Jul;52(7):1391-9. Epub 2009 May 7.PMID: 19421731 [PubMed - indexed for MEDLINE]Related articles

Prolonged islet graft survival in NOD mice by blockade of the CD40-CD154 pathway of T-cell costimulation.

Molano RD, Berney T, Li H, Cattan P, Pileggi A, Vizzardelli C, Kenyon NS, Ricordi C, Burkly LC, Inverardi L.

Diabetes. 2001 Feb;50(2):270-6.PMID: 11272136 [PubMed - indexed for MEDLINE]Related articlesFree article

Aggressive skin allograft rejection in CD28-/- mice independent of the CD40/CD40L costimulatory pathway.

Ha J, Bingaman AW, Durham MM, Pearson TC, Larsen CP.

Transpl Immunol. 2001 Oct;9(1):13-7.PMID: 11680567 [PubMed - indexed for MEDLINE]Related articles

Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.

Bour-Jordan H, Salomon BL, Thompson HL, Szot GL, Bernhard MR, Bluestone JA.

J Clin Invest. 2004 Oct;114(7):979-87.PMID: 15467837 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of regulatory T cells and effector T cell deletion in tolerance induction by costimulation blockade.

Verbinnen B, Billiau AD, Vermeiren J, Galicia G, Bullens DM, Boon L, Cadot P, Hens G, Dewolf-Peeters C, Van Gool SW, Ceuppens JL.

J Immunol. 2008 Jul 15;181(2):1034-42.PMID: 18606655 [PubMed - indexed for MEDLINE]Related articlesFree article

Protective role of programmed death 1 ligand 1 (PD-L1)in nonobese diabetic mice: the paradox in transgenic models.

Wang CJ, Chou FC, Chu CH, Wu JC, Lin SH, Chang DM, Sytwu HK.

Diabetes. 2008 Jul;57(7):1861-9. Epub 2008 Apr 16.PMID: 18420489 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells.

Mariño E, Villanueva J, Walters S, Liuwantara D, Mackay F, Grey ST.

Diabetes. 2009 Jul;58(7):1568-77. Epub 2009 Mar 31.PMID: 19336675 [PubMed - indexed for MEDLINE]Related articlesFree article

Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice.

Makhlouf L, Grey ST, Dong V, Csizmadia E, Arvelo MB, Auchincloss H Jr, Ferran C, Sayegh MH.

Transplantation. 2004 Apr 15;77(7):990-7.PMID: 15087759 [PubMed - indexed for MEDLINE]Related articles

Preconditioning of NOD mice with anti-CD8 mAb and costimulatory blockade enhances chimerism and tolerance and prevents diabetes, while depletion of alpha beta-TCR+ and CD4+ cells negates the effect.

Ildstad ST, Chilton PM, Xu H, Domenick MA, Ray MB.

Blood. 2005 Mar 15;105(6):2577-84. Epub 2004 Oct 21.PMID: 15498851 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of tolerance in murine autoimmune diabetes by transient blockade of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway.

Moriyama H, Yokono K, Amano K, Nagata M, Hasegawa Y, Okamoto N, Tsukamoto K, Miki M, Yoneda R, Yagi N, Tominaga Y, Kikutani H, Hioki K, Okumura K, Yagita H, Kasuga M.

J Immunol. 1996 Oct 15;157(8):3737-43.PMID: 8871677 [PubMed - indexed for MEDLINE]Related articles

CD4+CD25+ regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells.

Mukherjee R, Chaturvedi P, Qin HY, Singh B.

J Autoimmun. 2003 Nov;21(3):221-37.PMID: 14599847 [PubMed - indexed for MEDLINE]Related articles

Unique role of CD4+CD62L+ regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice.

You S, Slehoffer G, Barriot S, Bach JF, Chatenoud L.

Proc Natl Acad Sci U S A. 2004 Oct 5;101 Suppl 2:14580-5. Epub 2004 Aug 30.PMID: 15340148 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-12 administration reveals diabetogenic T cells in genetically resistant I-Ealpha-transgenic nonobese diabetic mice: resistance to autoimmune diabetes is associated with binding of Ealpha-derived peptides to the I-A(g7) molecule.

Trembleau S, Gregori S, Penna G, Gorny I, Adorini L.

J Immunol. 2001 Oct 1;167(7):4104-14.PMID: 11564833 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of autoantigen-specific Th2 and Tr1 regulatory T cells and modulation of autoimmune diabetes.

Chen C, Lee WH, Yun P, Snow P, Liu CP.

J Immunol. 2003 Jul 15;171(2):733-44.PMID: 12847240 [PubMed - indexed for MEDLINE]Related articlesFree article

Upregulating CD4+CD25+FOXP3+ regulatory T cells in pancreatic lymph nodes in diabetic NOD mice by adjuvant immunotherapy.

Tian B, Hao J, Zhang Y, Tian L, Yi H, O'Brien TD, Sutherland DE, Hering BJ, Guo Z.

Transplantation. 2009 Jan 27;87(2):198-206.PMID: 19155973 [PubMed - indexed for MEDLINE]Related articles