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    Results: 1 to 20 of 134

    1.

    Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance.

    Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mochizuki H, Kawamori R, Watada H.

    Diabetes. 2008 Aug;57(8):2083-91. Epub 2008 May 16.PMID: 18487450 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity.

    Liang H, Balas B, Tantiwong P, Dube J, Goodpaster BH, O'Doherty RM, DeFronzo RA, Richardson A, Musi N, Ward WF.

    Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E945-54. Epub 2009 Feb 10.PMID: 19208857 [PubMed - indexed for MEDLINE]Related articles

    3.

    Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice.

    Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H, Kawamori R, Watada H.

    Diabetologia. 2007 Jan;50(1):131-41. Epub 2006 Nov 9.PMID: 17093946 [PubMed - indexed for MEDLINE]Related articles

    4.

    Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors.

    Speckmann B, Walter PL, Alili L, Reinehr R, Sies H, Klotz LO, Steinbrenner H.

    Hepatology. 2008 Dec;48(6):1998-2006.PMID: 18972406 [PubMed - indexed for MEDLINE]Related articles

    5.

    Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.

    Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM.

    Diabetes. 2009 Jul;58(7):1499-508. Epub 2009 Apr 14.PMID: 19366863 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia.

    Wu C, Khan SA, Peng LJ, Li H, Carmella SG, Lange AJ.

    Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E536-43. Epub 2006 Apr 18. Erratum in: Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E370. PMID: 16621898 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice.

    Gómez-Valadés AG, Méndez-Lucas A, Vidal-Alabró A, Blasco FX, Chillon M, Bartrons R, Bermúdez J, Perales JC.

    Diabetes. 2008 Aug;57(8):2199-210. Epub 2008 Apr 28.PMID: 18443203 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c.

    Ponugoti B, Fang S, Kemper JK.

    Mol Endocrinol. 2007 Nov;21(11):2698-712. Epub 2007 Jul 17.PMID: 17636037 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.

    Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME.

    J Biol Chem. 2007 May 25;282(21):15439-50. Epub 2007 Apr 6.PMID: 17416903 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism.

    Yubero P, Hondares E, Carmona MC, Rossell M, Gonzalez FJ, Iglesias R, Giralt M, Villarroya F.

    Endocrinology. 2004 Sep;145(9):4268-77. Epub 2004 Jun 3.PMID: 15178647 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects.

    Fanelli M, Filippi E, Sentinelli F, Romeo S, Fallarino M, Buzzetti R, Leonetti F, Baroni MG.

    Dis Markers. 2005;21(4):175-80.PMID: 16403952 [PubMed - indexed for MEDLINE]Related articles

    12.

    PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.

    Southgate RJ, Bruce CR, Carey AL, Steinberg GR, Walder K, Monks R, Watt MJ, Hawley JA, Birnbaum MJ, Febbraio MA.

    FASEB J. 2005 Dec;19(14):2072-4. Epub 2005 Oct 3. Retraction in: FASEB J. 2009 Aug;23(8):2790. PMID: 16203862 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    PGC-1beta in the regulation of hepatic glucose and energy metabolism.

    Lin J, Tarr PT, Yang R, Rhee J, Puigserver P, Newgard CB, Spiegelman BM.

    J Biol Chem. 2003 Aug 15;278(33):30843-8. Epub 2003 Jun 13.PMID: 12807885 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Cold-induced PGC-1alpha expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway.

    Oliveira RL, Ueno M, de Souza CT, Pereira-da-Silva M, Gasparetti AL, Bezzera RM, Alberici LC, Vercesi AE, Saad MJ, Velloso LA.

    Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E686-95. Epub 2004 May 27.PMID: 15165993 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

    Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M.

    Nat Med. 2004 May;10(5):530-4. Epub 2004 Apr 25. Erratum in: Nat Med. 2004 Jul;7(10):755. PMID: 15107844 [PubMed - indexed for MEDLINE]Related articles

    16.

    Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis.

    Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM.

    Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4012-7. Epub 2003 Mar 21.PMID: 12651943 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

    Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM.

    Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6570-5. Epub 2004 Apr 20. Erratum in: Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10405. PMID: 15100410 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Restoration of sterol-regulatory-element-binding protein-1c gene expression in HepG2 cells by peroxisome-proliferator-activated receptor-gamma co-activator-1alpha.

    Oberkofler H, Schraml E, Krempler F, Patsch W.

    Biochem J. 2004 Jul 15;381(Pt 2):357-63.PMID: 15084148 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Short-term inhibition of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice.

    De Souza CT, Araújo EP, Prada PO, Saad MJ, Boschero AC, Velloso LA.

    Diabetologia. 2005 Sep;48(9):1860-71. Epub 2005 Jul 16.PMID: 16025253 [PubMed - indexed for MEDLINE]Related articles

    20.

    Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise.

    De Filippis E, Alvarez G, Berria R, Cusi K, Everman S, Meyer C, Mandarino LJ.

    Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E607-14. Epub 2008 Jan 8.PMID: 18182465 [PubMed - indexed for MEDLINE]Related articlesFree article

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