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    Results: 1 to 20 of 100

    1.

    Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.

    Goldsworthy M, Hugill A, Freeman H, Horner E, Shimomura K, Bogani D, Pieles G, Mijat V, Arkell R, Bhattacharya S, Ashcroft FM, Cox RD.

    Diabetes. 2008 Aug;57(8):2234-44. Epub 2008 May 13.PMID: 18477811 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.

    Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldsworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD.

    Diabetologia. 2005 Apr;48(4):675-86. Epub 2005 Feb 24.PMID: 15729571 [PubMed - indexed for MEDLINE]Related articles

    3.

    Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.

    Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I.

    J Biol Chem. 2006 Feb 24;281(8):5246-57. Epub 2005 Dec 23.PMID: 16377800 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

    Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.

    Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E217-29. Epub 2007 Sep 25.PMID: 17895289 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.

    Wilson ME, Yang KY, Kalousova A, Lau J, Kosaka Y, Lynn FC, Wang J, Mrejen C, Episkopou V, Clevers HC, German MS.

    Diabetes. 2005 Dec;54(12):3402-9.PMID: 16306355 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells.

    Wang H, Iezzi M, Theander S, Antinozzi PA, Gauthier BR, Halban PA, Wollheim CB.

    Diabetologia. 2005 Apr;48(4):720-31. Epub 2005 Mar 9.PMID: 15756539 [PubMed - indexed for MEDLINE]Related articles

    7.

    Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion.

    Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, Piston DW, Wright CV, Powers AC.

    J Biol Chem. 2002 Mar 29;277(13):11225-32. Epub 2002 Jan 7.PMID: 11781323 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes.

    Kanezaki Y, Obata T, Matsushima R, Minami A, Yuasa T, Kishi K, Bando Y, Uehara H, Izumi K, Mitani T, Matsumoto M, Takeshita Y, Nakaya Y, Matsumoto T, Ebina Y.

    Endocr J. 2004 Apr;51(2):133-44.PMID: 15118262 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

    Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T.

    J Clin Invest. 1997 Mar 1;99(5):861-6.PMID: 9062343 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.

    Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.

    J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.PMID: 15546857 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.

    Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M.

    Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3818-23.PMID: 11904435 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress.

    Freeman H, Shimomura K, Cox RD, Ashcroft FM.

    Biochem Soc Trans. 2006 Nov;34(Pt 5):806-10.PMID: 17052203 [PubMed - indexed for MEDLINE]Related articles

    13.

    Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.

    MacFarlane WM, Chapman JC, Shepherd RM, Hashmi MN, Kamimura N, Cosgrove KE, O'Brien RE, Barnes PD, Hart AW, Docherty HM, Lindley KJ, Aynsley-Green A, James RF, Docherty K, Dunne MJ.

    J Biol Chem. 1999 Nov 26;274(48):34059-66.PMID: 10567373 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

    Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG.

    Nat Genet. 2000 Nov;26(3):336-40.PMID: 11062475 [PubMed - indexed for MEDLINE]Related articles

    15.

    Disruption of G protein-coupled receptor 39 impairs insulin secretion in vivo.

    Tremblay F, Richard AM, Will S, Syed J, Stedman N, Perreault M, Gimeno RE.

    Endocrinology. 2009 Jun;150(6):2586-95. Epub 2009 Feb 12.PMID: 19213841 [PubMed - indexed for MEDLINE]Related articles

    16.

    Foxa2 regulates multiple pathways of insulin secretion.

    Lantz KA, Vatamaniuk MZ, Brestelli JE, Friedman JR, Matschinsky FM, Kaestner KH.

    J Clin Invest. 2004 Aug;114(4):512-20.PMID: 15314688 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.

    Iguchi H, Ikeda Y, Okamura M, Tanaka T, Urashima Y, Ohguchi H, Takayasu S, Kojima N, Iwasaki S, Ohashi R, Jiang S, Hasegawa G, Ioka RX, Magoori K, Sumi K, Maejima T, Uchida A, Naito M, Osborne TF, Yanagisawa M, Yamamoto TT, Kodama T, Sakai J.

    J Biol Chem. 2005 Nov 11;280(45):37669-80. Epub 2005 Sep 7.PMID: 16148004 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes.

    Elbein SC, Sun J, Scroggin E, Teng K, Hasstedt SJ.

    Diabetes Care. 2001 Mar;24(3):472-8.PMID: 11289470 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Double-gene ablation of SSTR1 and SSTR5 results in hyperinsulinemia and improved glucose tolerance in mice.

    Wang XP, Norman MA, Yang J, Cheung A, Moldovan S, Demayo FJ, Brunicardi FC.

    Surgery. 2004 Sep;136(3):585-92.PMID: 15349106 [PubMed - indexed for MEDLINE]Related articles

    20.

    Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes.

    Müssig K, Staiger H, Machicao F, Stancáková A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring HU.

    J Clin Endocrinol Metab. 2009 Apr;94(4):1353-60. Epub 2009 Jan 13.PMID: 19141580 [PubMed - indexed for MEDLINE]Related articles

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