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    Results: 1 to 20 of 129

    1.

    Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice.

    Tan CP, Feng Y, Zhou YP, Eiermann GJ, Petrov A, Zhou C, Lin S, Salituro G, Meinke P, Mosley R, Akiyama TE, Einstein M, Kumar S, Berger JP, Mills SG, Thornberry NA, Yang L, Howard AD.

    Diabetes. 2008 Aug;57(8):2211-9. Epub 2008 May 13.PMID: 18477808 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.

    Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y.

    Diabetes. 2009 May;58(5):1067-76. Erratum in: Diabetes. 2009 Jul;58(7):1721. PMID: 19401434 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat.

    Doshi LS, Brahma MK, Sayyed SG, Dixit AV, Chandak PG, Pamidiboina V, Motiwala HF, Sharma SD, Nemmani KV.

    Metabolism. 2009 Mar;58(3):333-43.PMID: 19217448 [PubMed - indexed for MEDLINE]Related articles

    4.

    The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.

    Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V.

    Diabetes. 2008 Sep;57(9):2432-7. Epub 2008 Jun 16. Erratum in: Diabetes. 2008 Nov;57(11):3166. PMID: 18559658 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

    Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, Luo J, Lin DC, Poitout V.

    Diabetes. 2007 Apr;56(4):1087-94.PMID: 17395749 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse.

    Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H.

    Cell Metab. 2005 Apr;1(4):245-58.PMID: 16054069 [PubMed - indexed for MEDLINE]Related articles

    7.

    Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.

    Briscoe CP, Peat AJ, McKeown SC, Corbett DF, Goetz AS, Littleton TR, McCoy DC, Kenakin TP, Andrews JL, Ammala C, Fornwald JA, Ignar DM, Jenkinson S.

    Br J Pharmacol. 2006 Jul;148(5):619-28. Epub 2006 May 15.PMID: 16702987 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease.

    Lan H, Hoos LM, Liu L, Tetzloff G, Hu W, Abbondanzo SJ, Vassileva G, Gustafson EL, Hedrick JA, Davis HR.

    Diabetes. 2008 Nov;57(11):2999-3006. Epub 2008 Aug 4.PMID: 18678612 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Disruption of G protein-coupled receptor 39 impairs insulin secretion in vivo.

    Tremblay F, Richard AM, Will S, Syed J, Stedman N, Perreault M, Gimeno RE.

    Endocrinology. 2009 Jun;150(6):2586-95. Epub 2009 Feb 12.PMID: 19213841 [PubMed - indexed for MEDLINE]Related articles

    10.

    Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

    Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi K, Hosoya M, Tanaka Y, Uejima H, Tanaka H, Maruyama M, Satoh R, Okubo S, Kizawa H, Komatsu H, Matsumura F, Noguchi Y, Shinohara T, Hinuma S, Fujisawa Y, Fujino M.

    Nature. 2003 Mar 13;422(6928):173-6. Epub 2003 Feb 23.PMID: 12629551 [PubMed - indexed for MEDLINE]Related articles

    11.

    The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: investigations using GPR40-knockout mice.

    Brownlie R, Mayers RM, Pierce JA, Marley AE, Smith DM.

    Biochem Soc Trans. 2008 Oct;36(Pt 5):950-4. Review.PMID: 18793167 [PubMed - indexed for MEDLINE]Related articles

    12.

    Overexpression of GPR40 in Pancreatic {beta}-Cells Augments Glucose Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice.

    Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y.

    Diabetes. 2009 Feb 19. [Epub ahead of print]PMID: 19208915 [PubMed - as supplied by publisher]Related articles

    13.

    Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release.

    Fujiwara K, Maekawa F, Yada T.

    Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E670-7. Epub 2005 May 24.PMID: 15914509 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.

    Schnell S, Schaefer M, Schöfl C.

    Mol Cell Endocrinol. 2007 Jan 15;263(1-2):173-80. Epub 2006 Nov 13.PMID: 17101212 [PubMed - indexed for MEDLINE]Related articles

    15.

    Glucagon-like peptide-1 and islet lipolysis.

    Sörhede Winzell M, Ahrén B.

    Horm Metab Res. 2004 Nov-Dec;36(11-12):795-803.PMID: 15655711 [PubMed - indexed for MEDLINE]Related articles

    16.

    Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization.

    Vettor R, Granzotto M, De Stefani D, Trevellin E, Rossato M, Farina MG, Milan G, Pilon C, Nigro A, Federspil G, Vigneri R, Vitiello L, Rizzuto R, Baratta R, Frittitta L.

    J Clin Endocrinol Metab. 2008 Sep;93(9):3541-50. Epub 2008 Jun 26.PMID: 18583466 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1.

    Zhang Y, Xu M, Zhang S, Yan L, Yang C, Lu W, Li Y, Cheng H.

    J Mol Endocrinol. 2007 Jun;38(6):651-61.PMID: 17556534 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.

    Chu ZL, Jones RM, He H, Carroll C, Gutierrez V, Lucman A, Moloney M, Gao H, Mondala H, Bagnol D, Unett D, Liang Y, Demarest K, Semple G, Behan DP, Leonard J.

    Endocrinology. 2007 Jun;148(6):2601-9. Epub 2007 Feb 8. Erratum in: Endocrinology. 2007 Oct;148(10):4753. PMID: 17289847 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice.

    Ahrén B, Simonsson E, Scheurink AJ, Mulder H, Myrsén U, Sundler F.

    Metabolism. 1997 Jan;46(1):97-106.PMID: 9005977 [PubMed - indexed for MEDLINE]Related articles

    20.

    Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.

    Alquier T, Peyot ML, Latour MG, Kebede M, Sorensen CM, Gesta S, Ronald Kahn C, Smith RD, Jetton TL, Metz TO, Prentki M, Poitout V.

    Diabetes. 2009 Nov;58(11):2607-15. Epub 2009 Aug 31.PMID: 19720802 [PubMed - in process]Related articles

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