PubMed

Changes in gamma-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1.

Carter DB, Dunn E, Pauley AM, McKinley DD, Fleck TJ, Ellerbrook BR, Stratman NC, Zhou X, Himes CS, Nye JS, Tomasselli A, Yan R.

Mol Neurodegener. 2008 May 12;3:6.PMID: 18474109 [PubMed - in process]Related articlesFree article

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.

Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.

J Neurochem. 2006 Feb;96(3):732-42. Epub 2006 Jan 9.PMID: 16405513 [PubMed - indexed for MEDLINE]Related articles

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.

Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM.

J Biol Chem. 2003 Jun 20;278(25):22475-81. Epub 2003 Apr 8.PMID: 12684521 [PubMed - indexed for MEDLINE]Related articlesFree article

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.

Wang J, Brunkan AL, Hecimovic S, Walker E, Goate A.

Neurobiol Dis. 2004 Apr;15(3):654-66.PMID: 15056474 [PubMed - indexed for MEDLINE]Related articles

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.

Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C.

J Biol Chem. 2008 Jan 11;283(2):677-83. Epub 2007 Oct 24.PMID: 17962197 [PubMed - indexed for MEDLINE]Related articlesFree article

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S.

J Biol Chem. 2007 Aug 24;282(34):24504-13. Epub 2007 Jun 15.PMID: 17573346 [PubMed - indexed for MEDLINE]Related articlesFree article

The large hydrophilic loop of presenilin 1 is important for regulating {gamma}-secretase complex assembly and dictating the A{beta} profile without affecting notch processing.

Wanngren J, Franberg J, Svensson AI, Laudon H, Winblad B, Liu F, Naslund J, Lundkvist J, Karlstrom H.

J Biol Chem. 2010 Jan 27. [Epub ahead of print]PMID: 20106965 [PubMed - as supplied by publisher]Related articlesFree article

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.

Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S.

J Biol Chem. 2008 Jun 20;283(25):17049-54. Epub 2008 Apr 21.PMID: 18426795 [PubMed - indexed for MEDLINE]Related articlesFree article

A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.

Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D.

J Neurochem. 2006 Jan;96(1):118-25. Epub 2005 Nov 21.PMID: 16300640 [PubMed - indexed for MEDLINE]Related articles

Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.

Wrigley JD, Nunn EJ, Nyabi O, Clarke EE, Hunt P, Nadin A, De Strooper B, Shearman MS, Beher D.

J Neurochem. 2004 Sep;90(6):1312-20.PMID: 15341515 [PubMed - indexed for MEDLINE]Related articles

Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.

Futai E, Yagishita S, Ishiura S.

J Biol Chem. 2009 May 8;284(19):13013-22. Epub 2009 Mar 2.PMID: 19254953 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of gamma-secretase inhibitor potency determinants on presenilin.

Zhao B, Yu M, Neitzel M, Marugg J, Jagodzinski J, Lee M, Hu K, Schenk D, Yednock T, Basi G.

J Biol Chem. 2008 Feb 1;283(5):2927-38. Epub 2007 Nov 21.PMID: 18032377 [PubMed - indexed for MEDLINE]Related articlesFree article

Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.

Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O.

PLoS One. 2009 Nov 18;4(11):e7893.PMID: 19924286 [PubMed - in process]Related articlesFree article

From presenilinase to gamma-secretase, cleave to capacitate.

Xia W.

Curr Alzheimer Res. 2008 Apr;5(2):172-8. Review.PMID: 18393802 [PubMed - indexed for MEDLINE]Related articles

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H.

J Neurosci. 2006 Apr 5;26(14):3821-8.PMID: 16597736 [PubMed - indexed for MEDLINE]Related articlesFree article

Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity.

Brunkan AL, Martinez M, Wang J, Walker ES, Beher D, Shearman MS, Goate AM.

J Neurochem. 2005 Sep;94(5):1315-28. Epub 2005 Jul 7.PMID: 16001967 [PubMed - indexed for MEDLINE]Related articles

Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.

Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kröper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C.

J Biol Chem. 2008 Oct 31;283(44):30121-8. Epub 2008 Sep 3.PMID: 18768471 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1.

Liu Y, Zhang YW, Wang X, Zhang H, You X, Liao FF, Xu H.

J Biol Chem. 2009 May 1;284(18):12145-52. Epub 2009 Mar 10.PMID: 19276086 [PubMed - indexed for MEDLINE]Related articles

gamma-Secretase modulators.

Wolfe MS.

Curr Alzheimer Res. 2007 Dec;4(5):571-3. Review.PMID: 18220525 [PubMed - indexed for MEDLINE]Related articles

gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.

Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U.

J Neurochem. 2005 Nov;95(3):880-90. Epub 2005 Aug 31.PMID: 16135086 [PubMed - indexed for MEDLINE]Related articles