PubMed

Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice.

Gómez-Valadés AG, Méndez-Lucas A, Vidal-Alabró A, Blasco FX, Chillon M, Bartrons R, Bermúdez J, Perales JC.

Diabetes. 2008 Aug;57(8):2199-210. Epub 2008 Apr 28.PMID: 18443203 [PubMed - indexed for MEDLINE]Related articlesFree article

knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice.

Qiao L, MacLean PS, You H, Schaack J, Shao J.

Endocrinology. 2006 Jun;147(6):3060-9. Epub 2006 Mar 16.PMID: 16543372 [PubMed - indexed for MEDLINE]Related articlesFree article

Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity.

Liang H, Balas B, Tantiwong P, Dube J, Goodpaster BH, O'Doherty RM, DeFronzo RA, Richardson A, Musi N, Ward WF.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E945-54. Epub 2009 Feb 10.PMID: 19208857 [PubMed - indexed for MEDLINE]Related articles

Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells.

Xu H, Yang Q, Shen M, Huang X, Dembski M, Gimeno R, Tartaglia LA, Kapeller R, Wu Z.

J Biol Chem. 2005 Oct 28;280(43):36013-8. Epub 2005 Aug 26.PMID: 16126724 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.

Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM.

Nature. 2001 Sep 13;413(6852):131-8.PMID: 11557972 [PubMed - indexed for MEDLINE]Related articles

Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance.

Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mochizuki H, Kawamori R, Watada H.

Diabetes. 2008 Aug;57(8):2083-91. Epub 2008 May 16.PMID: 18487450 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver.

Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA.

Cell Metab. 2007 Apr;5(4):313-20.PMID: 17403375 [PubMed - indexed for MEDLINE]Related articlesFree article

A mutation in the peroxisome proliferator-activated receptor gamma-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice.

Olswang Y, Cohen H, Papo O, Cassuto H, Croniger CM, Hakimi P, Tilghman SM, Hanson RW, Reshef L.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):625-30. Epub 2002 Jan 15.PMID: 11792850 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice.

Altomonte J, Richter A, Harbaran S, Suriawinata J, Nakae J, Thung SN, Meseck M, Accili D, Dong H.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E718-28. Epub 2003 Jun 3.PMID: 12783775 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute and selective regulation of glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase in adipose tissue by thiazolidinediones in type 2 diabetes.

Cadoudal T, Blouin JM, Collinet M, Fouque F, Tan GD, Loizon E, Beale EG, Frayn KN, Karpe F, Vidal H, Benelli C, Forest C.

Diabetologia. 2007 Mar;50(3):666-75. Epub 2007 Jan 23.PMID: 17242918 [PubMed - indexed for MEDLINE]Related articles

Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice.

Friedman JE, Sun Y, Ishizuka T, Farrell CJ, McCormack SE, Herron LM, Hakimi P, Lechner P, Yun JS.

J Biol Chem. 1997 Dec 12;272(50):31475-81.PMID: 9395482 [PubMed - indexed for MEDLINE]Related articlesFree article

Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice.

Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H, Kawamori R, Watada H.

Diabetologia. 2007 Jan;50(1):131-41. Epub 2006 Nov 9.PMID: 17093946 [PubMed - indexed for MEDLINE]Related articles

Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia.

Wu C, Khan SA, Peng LJ, Li H, Carmella SG, Lange AJ.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E536-43. Epub 2006 Apr 18. Erratum in: Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E370. PMID: 16621898 [PubMed - indexed for MEDLINE]Related articlesFree article

PCK1 and PCK2 as candidate diabetes and obesity genes.

Beale EG, Harvey BJ, Forest C.

Cell Biochem Biophys. 2007;48(2-3):89-95. Review.PMID: 17709878 [PubMed - indexed for MEDLINE]Related articles

The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism.

Yubero P, Hondares E, Carmona MC, Rossell M, Gonzalez FJ, Iglesias R, Giralt M, Villarroya F.

Endocrinology. 2004 Sep;145(9):4268-77. Epub 2004 Jun 3.PMID: 15178647 [PubMed - indexed for MEDLINE]Related articlesFree article

The transcription factor CCAAT/enhancer-binding protein beta regulates gluconeogenesis and phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes.

Arizmendi C, Liu S, Croniger C, Poli V, Friedman JE.

J Biol Chem. 1999 May 7;274(19):13033-40.PMID: 10224054 [PubMed - indexed for MEDLINE]Related articlesFree article

Merit of physical exercise to reverse the higher gene expression of hepatic phosphoenolpyruvate carboxykinase in obese Zucker rats.

Chang SP, Chen YH, Chang WC, Liu IM, Cheng JT.

Life Sci. 2006 Jun 13;79(3):240-6. Epub 2006 Feb 3.PMID: 16458327 [PubMed - indexed for MEDLINE]Related articles

Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.

Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM.

Diabetes. 2009 Jul;58(7):1499-508. Epub 2009 Apr 14.PMID: 19366863 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription.

Herzog B, Cardenas J, Hall RK, Villena JA, Budge PJ, Giguère V, Granner DK, Kralli A.

J Biol Chem. 2006 Jan 6;281(1):99-106. Epub 2005 Nov 2.PMID: 16267049 [PubMed - indexed for MEDLINE]Related articlesFree article

DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression.

Nedumaran B, Hong S, Xie YB, Kim YH, Seo WY, Lee MW, Lee CH, Koo SH, Choi HS.

J Biol Chem. 2009 Oct 2;284(40):27511-23. Epub 2009 Aug 3.PMID: 19651776 [PubMed - indexed for MEDLINE]Related articles