PubMed

Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*.

Bhattacharya R, Kwon J, Wang E, Mukherjee P, Mukhopadhyay D.

J Mol Signal. 2008 Mar 31;3:8.PMID: 18377662 [PubMed - in process]Related articlesFree article

Dopamine regulates phosphorylation of VEGF receptor 2 by engaging Src-homology-2-domain-containing protein tyrosine phosphatase 2.

Sinha S, Vohra PK, Bhattacharya R, Dutta S, Sinha S, Mukhopadhyay D.

J Cell Sci. 2009 Sep 15;122(Pt 18):3385-92. Epub 2009 Aug 25.PMID: 19706677 [PubMed - indexed for MEDLINE]Related articles

Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells.

Nakamura Y, Patrushev N, Inomata H, Mehta D, Urao N, Kim HW, Razvi M, Kini V, Mahadev K, Goldstein BJ, McKinney R, Fukai T, Ushio-Fukai M.

Circ Res. 2008 May 23;102(10):1182-91. Epub 2008 May 1.PMID: 18451337 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling.

Bhattacharya R, Kang-Decker N, Hughes DA, Mukherjee P, Shah V, McNiven MA, Mukhopadhyay D.

FASEB J. 2005 Oct;19(12):1692-4. Epub 2005 Jul 27.PMID: 16049137 [PubMed - indexed for MEDLINE]Related articlesFree article

Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for embrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth factor I receptor.

Ling Y, Maile LA, Clemmons DR.

Mol Endocrinol. 2003 Sep;17(9):1824-33. Epub 2003 Jun 5.PMID: 12791772 [PubMed - indexed for MEDLINE]Related articlesFree article

SiRNA targeting SHP-1 accelerates angiogenesis in a rat model of hindlimb ischemia.

Sugano M, Tsuchida K, Maeda T, Makino N.

Atherosclerosis. 2007 Mar;191(1):33-9. Epub 2006 May 24.PMID: 16725144 [PubMed - indexed for MEDLINE]Related articles

p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 membrane recruitment.

Xi G, Shen X, Clemmons DR.

Mol Endocrinol. 2008 Sep;22(9):2162-75. Epub 2008 Jul 7.PMID: 18606861 [PubMed - indexed for MEDLINE]Related articlesFree article

IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis.

Meyer RD, Sacks DB, Rahimi N.

PLoS One. 2008;3(12):e3848. Epub 2008 Dec 3.PMID: 19050761 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.

Ewan LC, Jopling HM, Jia H, Mittar S, Bagherzadeh A, Howell GJ, Walker JH, Zachary IC, Ponnambalam S.

Traffic. 2006 Sep;7(9):1270-82.PMID: 17004325 [PubMed - indexed for MEDLINE]Related articles

The tyrosine phosphatase, SHP-1, is a negative regulator of endothelial superoxide formation.

Krötz F, Engelbrecht B, Buerkle MA, Bassermann F, Bridell H, Gloe T, Duyster J, Pohl U, Sohn HY.

J Am Coll Cardiol. 2005 May 17;45(10):1700-6.PMID: 15893190 [PubMed - indexed for MEDLINE]Related articles

The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.

Godeny MD, Sayyah J, VonDerLinden D, Johns M, Ostrov DA, Caldwell-Busby J, Sayeski PP.

Cell Signal. 2007 Mar;19(3):600-9. Epub 2006 Sep 1.PMID: 17027227 [PubMed - indexed for MEDLINE]Related articles

The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.

Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Ylä-Herttuala S, Wedge SR, Jürgensmeier JM, Alitalo K.

Cancer Res. 2008 Jun 15;68(12):4754-62.PMID: 18559522 [PubMed - indexed for MEDLINE]Related articlesFree article

Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1.

Nakata K, Yoshimaru T, Suzuki Y, Inoue T, Ra C, Yakura H, Mizuno K.

J Immunol. 2008 Oct 15;181(8):5414-24.PMID: 18832698 [PubMed - indexed for MEDLINE]Related articlesFree article

SHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling.

Yu Z, Maoui M, Zhao ZJ, Li Y, Shen SH.

FEBS J. 2006 May;273(10):2195-205.PMID: 16649996 [PubMed - indexed for MEDLINE]Related articles

Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor.

Gallicchio M, Mitola S, Valdembri D, Fantozzi R, Varnum B, Avanzi GC, Bussolino F.

Blood. 2005 Mar 1;105(5):1970-6. Epub 2004 Oct 26.PMID: 15507525 [PubMed - indexed for MEDLINE]Related articlesFree article

VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment.

Gampel A, Moss L, Jones MC, Brunton V, Norman JC, Mellor H.

Blood. 2006 Oct 15;108(8):2624-31. Epub 2006 Apr 25.PMID: 16638931 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization and development of a peptide substrate-based phosphate transfer assay for the human vascular endothelial growth factor receptor-2 tyrosine kinase.

Zhao G, Peery RB, Yingling JM.

Anal Biochem. 2007 Jan 15;360(2):196-206. Epub 2006 Nov 13.PMID: 17141171 [PubMed - indexed for MEDLINE]Related articles

Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis.

Bruns AF, Herbert SP, Odell AF, Jopling HM, Hooper NM, Zachary IC, Walker JH, Ponnambalam S.

Traffic. 2010 Jan;11(1):161-74. Epub .PMID: 19883397 [PubMed - in process]Related articles

Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases.

Singh H, Milner CS, Aguilar Hernandez MM, Patel N, Brindle NP.

Cell Signal. 2009 Aug;21(8):1346-50. Epub 2009 Apr 17.PMID: 19376222 [PubMed - indexed for MEDLINE]Related articles

New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.

Chabot C, Spring K, Gratton JP, Elchebly M, Royal I.

Mol Cell Biol. 2009 Jan;29(1):241-53. Epub 2008 Oct 20.PMID: 18936167 [PubMed - indexed for MEDLINE]Related articlesFree article