PubMed

Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance.

Tan BK, Heutling D, Chen J, Farhatullah S, Adya R, Keay SD, Kennedy CR, Lehnert H, Randeva HS.

Diabetes. 2008 Jun;57(6):1501-7. Epub 2008 Mar 28.PMID: 18375437 [PubMed - indexed for MEDLINE]Related articlesFree article

Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose.

Tan BK, Adya R, Farhatullah S, Lewandowski KC, O'Hare P, Lehnert H, Randeva HS.

Diabetes. 2008 Apr;57(4):801-8. Epub 2008 Jan 3.PMID: 18174521 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin and metformin regulate circulating and adipose tissue chemerin.

Tan BK, Chen J, Farhatullah S, Adya R, Kaur J, Heutling D, Lewandowski KC, O'Hare JP, Lehnert H, Randeva HS.

Diabetes. 2009 Sep;58(9):1971-7. Epub 2009 Jun 5.PMID: 19502420 [PubMed - indexed for MEDLINE]Related articles

Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1.

Tan BK, Adya R, Chen J, Farhatullah S, Heutling D, Mitchell D, Lehnert H, Randeva HS.

Cardiovasc Res. 2009 Aug 1;83(3):566-74. Epub 2009 May 4.PMID: 19414528 [PubMed - indexed for MEDLINE]Related articles

Raised serum, adipocyte, and adipose tissue retinol-binding protein 4 in overweight women with polycystic ovary syndrome: effects of gonadal and adrenal steroids.

Tan BK, Chen J, Lehnert H, Kennedy R, Randeva HS.

J Clin Endocrinol Metab. 2007 Jul;92(7):2764-72. Epub 2007 Apr 24.PMID: 17456573 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome.

Pasquali R, Gambineri A, Biscotti D, Vicennati V, Gagliardi L, Colitta D, Fiorini S, Cognigni GE, Filicori M, Morselli-Labate AM.

J Clin Endocrinol Metab. 2000 Aug;85(8):2767-74.PMID: 10946879 [PubMed - indexed for MEDLINE]Related articlesFree article

Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment.

Heutling D, Schulz H, Nickel I, Kleinstein J, Kaltwasser P, Westphal S, Mittermayer F, Wolzt M, Krzyzanowska K, Randeva H, Schernthaner G, Lehnert H.

J Clin Endocrinol Metab. 2008 Jan;93(1):82-90. Epub 2007 Nov 6.PMID: 17986642 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome.

Jensterle M, Janez A, Mlinar B, Marc J, Prezelj J, Pfeifer M.

Eur J Endocrinol. 2008 Jun;158(6):793-801. Epub 2008 Mar 5.PMID: 18322300 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinol-binding protein 4 and insulin resistance in polycystic ovary syndrome.

Hutchison SK, Harrison C, Stepto N, Meyer C, Teede HJ.

Diabetes Care. 2008 Jul;31(7):1427-32. Epub 2008 Apr 4.PMID: 18390799 [PubMed - indexed for MEDLINE]Related articlesFree article

Endocrine and metabolic effects of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome: a randomized study.

Morin-Papunen LC, Vauhkonen I, Koivunen RM, Ruokonen A, Martikainen HK, Tapanainen JS.

J Clin Endocrinol Metab. 2000 Sep;85(9):3161-8.PMID: 10999803 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance.

Arslanian SA, Lewy V, Danadian K, Saad R.

J Clin Endocrinol Metab. 2002 Apr;87(4):1555-9.PMID: 11932281 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: parallel increase in plasma visfatin.

Tan BK, Chen J, Digby JE, Keay SD, Kennedy CR, Randeva HS.

J Clin Endocrinol Metab. 2006 Dec;91(12):5022-8. Epub 2006 Sep 26.PMID: 17003086 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study.

Gambineri A, Patton L, Vaccina A, Cacciari M, Morselli-Labate AM, Cavazza C, Pagotto U, Pasquali R.

J Clin Endocrinol Metab. 2006 Oct;91(10):3970-80. Epub 2006 Jul 25.PMID: 16868063 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome.

Yilmaz M, Bukan N, Ayvaz G, Karakoç A, Törüner F, Cakir N, Arslan M.

Hum Reprod. 2005 Dec;20(12):3333-40. Epub 2005 Aug 25.PMID: 16123091 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of rosiglitazone and metformin on insulin resistance and serum androgen levels in obese and lean patients with polycystic ovary syndrome.

Yilmaz M, Biri A, Karakoç A, Törüner F, Bingöl B, Cakir N, Tiras B, Ayvaz G, Arslan M.

J Endocrinol Invest. 2005 Dec;28(11):1003-8.PMID: 16483179 [PubMed - indexed for MEDLINE]Related articles

Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy.

Diamanti-Kandarakis E, Spina G, Kouli C, Migdalis I.

J Clin Endocrinol Metab. 2001 Oct;86(10):4666-73.PMID: 11600523 [PubMed - indexed for MEDLINE]Related articlesFree article

The treatment of insulin resistance does not improve adrenal cytochrome P450c17alpha enzyme dysregulation in polycystic ovary syndrome.

Unlühizarci K, Keleştimur F, Sahin Y, Bayram F.

Eur J Endocrinol. 1999 Jan;140(1):56-61.PMID: 10037253 [PubMed - indexed for MEDLINE]Related articlesFree article

Incretin hormone secretion in women with polycystic ovary syndrome: roles of obesity, insulin sensitivity, and treatment with metformin.

Svendsen PF, Nilas L, Madsbad S, Holst JJ.

Metabolism. 2009 May;58(5):586-93.PMID: 19375579 [PubMed - indexed for MEDLINE]Related articles

Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome.

Pawelczyk L, Spaczynski RZ, Banaszewska B, Duleba AJ.

Eur J Obstet Gynecol Reprod Biol. 2004 Apr 15;113(2):209-13.PMID: 15063962 [PubMed - indexed for MEDLINE]Related articles

The effects of metformin on insulin resistance and ovarian steroidogenesis in women with polycystic ovary syndrome.

Unlühizarci K, Keleştimur F, Bayram F, Sahin Y, Tutuş A.

Clin Endocrinol (Oxf). 1999 Aug;51(2):231-6.PMID: 10468995 [PubMed - indexed for MEDLINE]Related articles