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    Results: 1 to 20 of 122

    1.

    Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function.

    Kebede M, Favaloro J, Gunton JE, Laybutt DR, Shaw M, Wong N, Fam BC, Aston-Mourney K, Rantzau C, Zulli A, Proietto J, Andrikopoulos S.

    Diabetes. 2008 Jul;57(7):1887-95. Epub 2008 Mar 28.PMID: 18375435 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.

    Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L.

    Biochem J. 2008 Apr 1;411(1):41-51.PMID: 18039179 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver.

    Visinoni S, Fam BC, Blair A, Rantzau C, Lamont BJ, Bouwman R, Watt MJ, Proietto J, Favaloro JM, Andrikopoulos S.

    Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1132-41. Epub 2008 Sep 9.PMID: 18780768 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.

    Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y.

    Diabetes. 2009 May;58(5):1067-76. Erratum in: Diabetes. 2009 Jul;58(7):1721. PMID: 19401434 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation.

    Liu Z, Tanabe K, Bernal-Mizrachi E, Permutt MA.

    Diabetologia. 2008 Apr;51(4):623-31. Epub 2008 Jan 25.PMID: 18219478 [PubMed - indexed for MEDLINE]Related articles

    6.

    Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

    Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.

    Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E217-29. Epub 2007 Sep 25.PMID: 17895289 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells.

    Baltrusch S, Langer S, Massa L, Tiedge M, Lenzen S.

    Endocrinology. 2006 Dec;147(12):5768-76. Epub 2006 Sep 15.PMID: 16980436 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Novel expression of liver FBPase in Langerhans islets of human and rat pancreas.

    Yáñez AJ, Bertinat R, Spichiger C, Carcamo JG, de Los Angeles García M, Concha II, Nualart F, Slebe JC.

    J Cell Physiol. 2005 Oct;205(1):19-24.PMID: 15965961 [PubMed - indexed for MEDLINE]Related articles

    9.

    Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes.

    Asghar Z, Yau D, Chan F, Leroith D, Chan CB, Wheeler MB.

    Diabetologia. 2006 Jan;49(1):90-9. Epub 2005 Dec 15. Erratum in: Diabetologia. 2006 Mar;49(3):614. PMID: 16362284 [PubMed - indexed for MEDLINE]Related articles

    10.

    TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells.

    da Silva Xavier G, Loder MK, McDonald A, Tarasov AI, Carzaniga R, Kronenberger K, Barg S, Rutter GA.

    Diabetes. 2009 Apr;58(4):894-905. Epub 2009 Jan 23.PMID: 19168596 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells.

    Welsh M, Christmansson L, Karlsson T, Sandler S, Welsh N.

    Mol Med. 1999 Mar;5(3):169-80.PMID: 10404514 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform.

    Escribano O, Guillén C, Nevado C, Gómez-Hernández A, Kahn CR, Benito M.

    Diabetes. 2009 Apr;58(4):820-8. Epub 2009 Jan 9.PMID: 19136656 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.

    Fex M, Haemmerle G, Wierup N, Dekker-Nitert M, Rehn M, Ristow M, Zechner R, Sundler F, Holm C, Eliasson L, Mulder H.

    Diabetologia. 2009 Feb;52(2):271-80. Epub 2008 Nov 21.PMID: 19023560 [PubMed - indexed for MEDLINE]Related articles

    14.

    Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

    Devedjian JC, George M, Casellas A, Pujol A, Visa J, Pelegrín M, Gros L, Bosch F.

    J Clin Invest. 2000 Mar;105(6):731-40.PMID: 10727441 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice.

    Iwashita N, Uchida T, Choi JB, Azuma K, Ogihara T, Ferrara N, Gerber H, Kawamori R, Inoue M, Watada H.

    Diabetologia. 2007 Feb;50(2):380-9. Epub 2006 Dec 16.PMID: 17180351 [PubMed - indexed for MEDLINE]Related articles

    16.

    Destruction of pancreatic beta-cells by transgenic induction of prostaglandin E2 in the islets.

    Oshima H, Taketo MM, Oshima M.

    J Biol Chem. 2006 Sep 29;281(39):29330-6. Epub 2006 Jul 27.PMID: 16873378 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.

    Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.

    Diabetes. 2008 May;57(5):1195-204. Epub 2008 Feb 14.PMID: 18276765 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes.

    Jackerott M, Møldrup A, Thams P, Galsgaard ED, Knudsen J, Lee YC, Nielsen JH.

    Diabetes. 2006 Oct;55(10):2705-12.PMID: 17003334 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis.

    Lamont BJ, Visinoni S, Fam BC, Kebede M, Weinrich B, Papapostolou S, Massinet H, Proietto J, Favaloro J, Andrikopoulos S.

    Endocrinology. 2006 Jun;147(6):2764-72. Epub 2006 Feb 23.PMID: 16497803 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Glucose intolerance and reduced islet blood flow in transgenic mice expressing the FRK tyrosine kinase under the control of the rat insulin promoter.

    Annerén C, Welsh M, Jansson L.

    Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1183-90. Epub 2006 Dec 19.PMID: 17179392 [PubMed - indexed for MEDLINE]Related articlesFree article

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