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Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds.

Roth J, Madoux F, Hodder P, Roush WR.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2628-32. Epub 2008 Mar 14.PMID: 18374567 [PubMed - indexed for MEDLINE]Related articlesFree article

Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening.

Madoux F, Li X, Chase P, Zastrow G, Cameron MD, Conkright JJ, Griffin PR, Thacher S, Hodder P.

Mol Pharmacol. 2008 Jun;73(6):1776-84. Epub 2008 Mar 11.PMID: 18334597 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists.

Barbay JK, Gong Y, Buntinx M, Li J, Claes C, Hornby PJ, Van Lommen G, Van Wauwe J, He W.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2544-8. Epub 2008 Mar 20.PMID: 18378452 [PubMed - indexed for MEDLINE]Related articles

Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins.

Gazit A, App H, McMahon G, Chen J, Levitzki A, Bohmer FD.

J Med Chem. 1996 May 24;39(11):2170-7.PMID: 8667360 [PubMed - indexed for MEDLINE]Related articles

Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity.

Tsou HR, Overbeek-Klumpers EG, Hallett WA, Reich MF, Floyd MB, Johnson BD, Michalak RS, Nilakantan R, Discafani C, Golas J, Rabindran SK, Shen R, Shi X, Wang YF, Upeslacis J, Wissner A.

J Med Chem. 2005 Feb 24;48(4):1107-31.PMID: 15715478 [PubMed - indexed for MEDLINE]Related articles

Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells.

Walther N, Jansen M, Akbary W, Ivell R.

Reprod Biol Endocrinol. 2006 Dec 19;4:64.PMID: 17176485 [PubMed - indexed for MEDLINE]Related articlesFree article

Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands.

Ji M, Chen J, Ding K, Wu X, Varady J, Levant B, Wang S.

Bioorg Med Chem Lett. 2005 Mar 15;15(6):1701-5.PMID: 15745825 [PubMed - indexed for MEDLINE]Related articles

Synthesis of novel anilinoquinolines as c-fms inhibitors.

Smalley TL Jr, Chamberlain SD, Mills WY, Musso DL, Randhawa SA, Ray JA, Samano V, Frick L.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6257-60. Epub 2007 Sep 7.PMID: 17870531 [PubMed - indexed for MEDLINE]Related articles

Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors.

Pannala M, Kher S, Wilson N, Gaudette J, Sircar I, Zhang SH, Bakhirev A, Yang G, Yuen P, Gorcsan F, Sakurai N, Barbosa M, Cheng JF.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5978-82. Epub 2007 Aug 21.PMID: 17827009 [PubMed - indexed for MEDLINE]Related articles

Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines.

Roach SL, Higuchi RI, Adams ME, Liu Y, Karanewsky DS, Marschke KB, Mais DE, Miner JN, Zhi L.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3504-8. Epub 2008 May 11.PMID: 18513967 [PubMed - indexed for MEDLINE]Related articles

Synthesis and structure-activity relationship for new series of 4-phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase.

Kubo K, Ohyama S, Shimizu T, Takami A, Murooka H, Nishitoba T, Kato S, Yagi M, Kobayashi Y, Iinuma N, Isoe T, Nakamura K, Iijima H, Osawa T, Izawa T.

Bioorg Med Chem. 2003 Nov 17;11(23):5117-33.PMID: 14604675 [PubMed - indexed for MEDLINE]Related articles

Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class.

von Sprecher A, Gerspacher M, Beck A, Kimmel S, Wiestner H, Anderson GP, Niederhauser U, Subramanian N, Bray MA.

Bioorg Med Chem Lett. 1998 Apr 21;8(8):965-70.PMID: 9871521 [PubMed - indexed for MEDLINE]Related articles

Tricyclic HIV integrase inhibitors: VI. SAR studies of 'benzyl flipped' C3-substituted pyrroloquinolines.

Metobo S, Mish M, Jin H, Jabri S, Lansdown R, Chen X, Tsiang M, Wright M, Kim CU.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1187-90. Epub 2008 Dec 25.PMID: 19167883 [PubMed - indexed for MEDLINE]Related articles

Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway.

Stauffer F, Maira SM, Furet P, García-Echeverría C.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1027-30. Epub 2007 Dec 15.PMID: 18248814 [PubMed - indexed for MEDLINE]Related articles

Discovery and SAR study of novel dihydroquinoline containing glucocorticoid receptor ligands.

Takahashi H, Bekkali Y, Capolino AJ, Gilmore T, Goldrick SE, Nelson RM, Terenzio D, Wang J, Zuvela-Jelaska L, Proudfoot J, Nabozny G, Thomson D.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1549-52. Epub 2005 Dec 28.PMID: 16386422 [PubMed - indexed for MEDLINE]Related articles

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors.

Wissner A, Berger DM, Boschelli DH, Floyd MB Jr, Greenberger LM, Gruber BC, Johnson BD, Mamuya N, Nilakantan R, Reich MF, Shen R, Tsou HR, Upeslacis E, Wang YF, Wu B, Ye F, Zhang N.

J Med Chem. 2000 Aug 24;43(17):3244-56.PMID: 10966743 [PubMed - indexed for MEDLINE]Related articles

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors.

Jiang R, Duckett D, Chen W, Habel J, Ling YY, LoGrasso P, Kamenecka TM.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6378-82. Epub 2007 Aug 26.PMID: 17911023 [PubMed - indexed for MEDLINE]Related articles

Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.

Lombardo LJ, Camuso A, Clark J, Fager K, Gullo-Brown J, Hunt JT, Inigo I, Kan D, Koplowitz B, Lee F, McGlinchey K, Qian L, Ricca C, Rovnyak G, Traeger S, Tokarski J, Williams DK, Wu LI, Zhao Y, Manne V, Bhide RS.

Bioorg Med Chem Lett. 2005 Apr 1;15(7):1895-9.PMID: 15780629 [PubMed - indexed for MEDLINE]Related articles

6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists: structure-activity exploration of eastern and western parts.

Ulven T, Little PB, Receveur JM, Frimurer TM, Rist O, Nørregaard PK, Högberg T.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):1070-5. Epub 2005 Nov 10.PMID: 16289819 [PubMed - indexed for MEDLINE]Related articles

Synthesis and bioevaluation of 22-hydroxyacuminatine analogs.

Grillet F, Baumlová B, Prévost G, Constant JF, Chaumeron S, Bigg DC, Greene AE, Kanazawa A.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2143-6. Epub 2008 Jan 30.PMID: 18276141 [PubMed - indexed for MEDLINE]Related articles