PubMed

RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease.

Peng F, Wu D, Gao B, Ingram AJ, Zhang B, Chorneyko K, McKenzie R, Krepinsky JC.

Diabetes. 2008 Jun;57(6):1683-92. Epub 2008 Mar 20.PMID: 18356410 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control.

Kolavennu V, Zeng L, Peng H, Wang Y, Danesh FR.

Diabetes. 2008 Mar;57(3):714-23. Epub 2007 Dec 14.PMID: 18083785 [PubMed - indexed for MEDLINE]Related articlesFree article

Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells.

Wu D, Peng F, Zhang B, Ingram AJ, Gao B, Krepinsky JC.

Diabetologia. 2007 Sep;50(9):2008-18. Epub 2007 Jul 11.PMID: 17622510 [PubMed - indexed for MEDLINE]Related articles

TGFbeta-induced RhoA activation and fibronectin production in mesangial cells require caveolae.

Peng F, Zhang B, Wu D, Ingram AJ, Gao B, Krepinsky JC.

Am J Physiol Renal Physiol. 2008 Jul;295(1):F153-64. Epub 2008 Apr 23.PMID: 18434385 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway.

Thallas-Bonke V, Thorpe SR, Coughlan MT, Fukami K, Yap FY, Sourris KC, Penfold SA, Bach LA, Cooper ME, Forbes JM.

Diabetes. 2008 Feb;57(2):460-9. Epub 2007 Oct 24.PMID: 17959934 [PubMed - indexed for MEDLINE]Related articlesFree article

3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy.

Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8301-5. Epub 2002 Jun 4.PMID: 12048257 [PubMed - indexed for MEDLINE]Related articlesFree article

Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.

Arita R, Hata Y, Nakao S, Kita T, Miura M, Kawahara S, Zandi S, Almulki L, Tayyari F, Shimokawa H, Hafezi-Moghadam A, Ishibashi T.

Diabetes. 2009 Jan;58(1):215-26. Epub 2008 Oct 7.PMID: 18840783 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes mellitus increases endothelin-1 gene transcription in rat kidney.

Hargrove GM, Dufresne J, Whiteside C, Muruve DA, Wong NC.

Kidney Int. 2000 Oct;58(4):1534-45.PMID: 11012888 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced expression of group IIA secreted phospholipase A2 by elevated glucose levels in cytokine-stimulated rat mesangial cells and in kidneys of diabetic rats.

Vlachojannis GJ, Scholz-Pedretti K, Fierlbeck W, Geiger H, Pfeilschifter J, Kaszkin M.

Clin Nephrol. 2005 May;63(5):356-67.PMID: 15909595 [PubMed - indexed for MEDLINE]Related articles

Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney.

Lee EA, Seo JY, Jiang Z, Yu MR, Kwon MK, Ha H, Lee HB.

Kidney Int. 2005 May;67(5):1762-71.PMID: 15840023 [PubMed - indexed for MEDLINE]Related articles

RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction.

Bivalacqua TJ, Champion HC, Usta MF, Cellek S, Chitaley K, Webb RC, Lewis RL, Mills TM, Hellstrom WJ, Kadowitz PJ.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9121-6. Epub 2004 Jun 7.PMID: 15184671 [PubMed - indexed for MEDLINE]Related articlesFree article

EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells.

Wu D, Peng F, Zhang B, Ingram AJ, Kelly DJ, Gilbert RE, Gao B, Kumar S, Krepinsky JC.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F822-34. Epub 2009 Jul 15.PMID: 19605547 [PubMed - indexed for MEDLINE]Related articles

The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats.

Gojo A, Utsunomiya K, Taniguchi K, Yokota T, Ishizawa S, Kanazawa Y, Kurata H, Tajima N.

Eur J Pharmacol. 2007 Jul 30;568(1-3):242-7. Epub 2007 Apr 20.PMID: 17511984 [PubMed - indexed for MEDLINE]Related articles

Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells.

Itoh Y, Kimoto K, Imaizumi M, Nakatsuka K.

Exp Eye Res. 2007 Mar;84(3):464-72. Epub 2007 Jan 10.PMID: 17217948 [PubMed - indexed for MEDLINE]Related articles

Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats.

Soliman H, Craig GP, Nagareddy P, Yuen VG, Lin G, Kumar U, McNeill JH, Macleod KM.

Cardiovasc Res. 2008 Jul 15;79(2):322-30. Epub 2008 Apr 14.PMID: 18411229 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina.

Yokota T, Utsunomiya K, Taniguchi K, Gojo A, Kurata H, Tajima N.

Jpn J Ophthalmol. 2007 Nov-Dec;51(6):424-30. Epub 2007 Dec 21.PMID: 18158592 [PubMed - indexed for MEDLINE]Related articles

Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.

Xie Z, Su W, Guo Z, Pang H, Post SR, Gong MC.

Cardiovasc Res. 2006 Feb 1;69(2):491-501. Epub 2005 Dec 5.PMID: 16336954 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy.

Nicholas SB, Aguiniga E, Ren Y, Kim J, Wong J, Govindarajan N, Noda M, Wang W, Kawano Y, Collins A, Hsueh WA.

Kidney Int. 2005 Apr;67(4):1297-307.PMID: 15780082 [PubMed - indexed for MEDLINE]Related articles

Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy.

Nagai K, Matsubara T, Mima A, Sumi E, Kanamori H, Iehara N, Fukatsu A, Yanagita M, Nakano T, Ishimoto Y, Kita T, Doi T, Arai H.

Kidney Int. 2005 Aug;68(2):552-61.PMID: 16014032 [PubMed - indexed for MEDLINE]Related articles

High glucose induces type 1 hexokinase gene expression in isolated glomeruli of diabetic rats and in mesangial cells.

Henningsen C, Zahner G, Thaiss F.

Nephron Physiol. 2003;93(3):p67-75.PMID: 12660493 [PubMed - indexed for MEDLINE]Related articles