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Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss.
Tomlinson JW, Finney J, Hughes BA, Hughes SV, Stewart PM.
Diabetes. 2008 Jun;57(6):1536-43. Epub 2008 Mar 13.PMID: 18340018 [PubMed - indexed for MEDLINE]Related articlesFree article
Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.
Tomlinson JW, Finney J, Gay C, Hughes BA, Hughes SV, Stewart PM.
Diabetes. 2008 Oct;57(10):2652-60. Epub 2008 Jul 15.PMID: 18633104 [PubMed - indexed for MEDLINE]Related articlesFree article
Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver.
Westerbacka J, Yki-Järvinen H, Vehkavaara S, Häkkinen AM, Andrew R, Wake DJ, Seckl JR, Walker BR.
J Clin Endocrinol Metab. 2003 Oct;88(10):4924-31.PMID: 14557475 [PubMed - indexed for MEDLINE]Related articlesFree article
Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.
Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH.
J Clin Endocrinol Metab. 1999 Mar;84(3):1022-7.PMID: 10084590 [PubMed - indexed for MEDLINE]Related articlesFree article
Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
Tomlinson JW, Moore JS, Clark PM, Holder G, Shakespeare L, Stewart PM.
J Clin Endocrinol Metab. 2004 Jun;89(6):2711-6.PMID: 15181046 [PubMed - indexed for MEDLINE]Related articlesFree article
Tissue-specific dysregulation of cortisol metabolism in human obesity.
Rask E, Olsson T, Söderberg S, Andrew R, Livingstone DE, Johnson O, Walker BR.
J Clin Endocrinol Metab. 2001 Mar;86(3):1418-21.PMID: 11238541 [PubMed - indexed for MEDLINE]Related articlesFree article
Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity.
Rask E, Walker BR, Söderberg S, Livingstone DE, Eliasson M, Johnson O, Andrew R, Olsson T.
J Clin Endocrinol Metab. 2002 Jul;87(7):3330-6.PMID: 12107245 [PubMed - indexed for MEDLINE]Related articlesFree article
Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats.
Drake AJ, Livingstone DE, Andrew R, Seckl JR, Morton NM, Walker BR.
Endocrinology. 2005 Feb;146(2):913-9. Epub 2004 Nov 18.PMID: 15550507 [PubMed - indexed for MEDLINE]Related articlesFree article
Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates.
Tsilchorozidou T, Honour JW, Conway GS.
J Clin Endocrinol Metab. 2003 Dec;88(12):5907-13.PMID: 14671189 [PubMed - indexed for MEDLINE]Related articlesFree article
Massive weight loss decreases corticosteroid-binding globulin levels and increases free cortisol in healthy obese patients: an adaptive phenomenon?
Manco M, Fernández-Real JM, Valera-Mora ME, Déchaud H, Nanni G, Tondolo V, Calvani M, Castagneto M, Pugeat M, Mingrone G.
Diabetes Care. 2007 Jun;30(6):1494-500.PMID: 17526821 [PubMed - indexed for MEDLINE]Related articlesFree article
Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men.
Wake DJ, Stimson RH, Tan GD, Homer NZ, Andrew R, Karpe F, Walker BR.
J Clin Endocrinol Metab. 2007 May;92(5):1848-56. Epub 2007 Feb 27.PMID: 17327378 [PubMed - indexed for MEDLINE]Related articlesFree article
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
Tomlinson JW, Sherlock M, Hughes B, Hughes SV, Kilvington F, Bartlett W, Courtney R, Rejto P, Carley W, Stewart PM.
J Clin Endocrinol Metab. 2007 Mar;92(3):857-64. Epub 2007 Jan 2.PMID: 17200165 [PubMed - indexed for MEDLINE]Related articlesFree article
Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men.
Stimson RH, Johnstone AM, Homer NZ, Wake DJ, Morton NM, Andrew R, Lobley GE, Walker BR.
J Clin Endocrinol Metab. 2007 Nov;92(11):4480-4. Epub 2007 Sep 4.PMID: 17785367 [PubMed - indexed for MEDLINE]Related articlesFree article
Effects of gonadectomy on glucocorticoid metabolism in obese Zucker rats.
Barat P, Livingstone DE, Elferink CM, McDonnell CR, Walker BR, Andrew R.
Endocrinology. 2007 Oct;148(10):4836-43. Epub 2007 Jul 12.PMID: 17628001 [PubMed - indexed for MEDLINE]Related articlesFree article
Reductions in plasma cytokine levels with weight loss improve insulin sensitivity in overweight and obese postmenopausal women.
Ryan AS, Nicklas BJ.
Diabetes Care. 2004 Jul;27(7):1699-705.PMID: 15220249 [PubMed - indexed for MEDLINE]Related articlesFree article
Evidence of increased visceral obesity and reduced physical fitness in healthy insulin-resistant first-degree relatives of type 2 diabetic patients.
Nyholm B, Nielsen MF, Kristensen K, Nielsen S, Østergård T, Pedersen SB, Christiansen T, Richelsen B, Jensen MD, Schmitz O.
Eur J Endocrinol. 2004 Feb;150(2):207-14.PMID: 14763919 [PubMed - indexed for MEDLINE]Related articlesFree article
Lactate and glycerol release from adipose tissue in lean, obese, and diabetic women from South Africa.
van der Merwe MT, Schlaphoff GP, Crowther NJ, Boyd IH, Gray IP, Joffe BI, Lönnroth PN.
J Clin Endocrinol Metab. 2001 Jul;86(7):3296-303.PMID: 11443204 [PubMed - indexed for MEDLINE]Related articlesFree article
The determinants of glycemic responses to diet restriction and weight loss in obesity and NIDDM.
Markovic TP, Jenkins AB, Campbell LV, Furler SM, Kraegen EW, Chisholm DJ.
Diabetes Care. 1998 May;21(5):687-94.PMID: 9589225 [PubMed - indexed for MEDLINE]Related articlesFree article
Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery.
Mingrone G, Manco M, Iaconelli A, Gniuli D, Bracaglia R, Leccesi L, Calvani M, Nolfe G, Basu S, Berria R.
Obesity (Silver Spring). 2008 Aug;16(8):1831-7. Epub 2008 Jun 5.PMID: 18535540 [PubMed - indexed for MEDLINE]Related articles
Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance.
Andrews RC, Herlihy O, Livingstone DE, Andrew R, Walker BR.
J Clin Endocrinol Metab. 2002 Dec;87(12):5587-93.PMID: 12466357 [PubMed - indexed for MEDLINE]Related articlesFree article
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