PubMed

Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis.

Valenti L, Rametta R, Dongiovanni P, Maggioni M, Fracanzani AL, Zappa M, Lattuada E, Roviaro G, Fargion S.

Diabetes. 2008 May;57(5):1355-62. Epub 2008 Mar 3.PMID: 18316359 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis.

Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE.

Am J Gastroenterol. 2008 Jun;103(6):1372-9. Epub 2008 May 28.PMID: 18510618 [PubMed - indexed for MEDLINE]Related articles

A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury.

Svegliati-Baroni G, Candelaresi C, Saccomanno S, Ferretti G, Bachetti T, Marzioni M, De Minicis S, Nobili L, Salzano R, Omenetti A, Pacetti D, Sigmund S, Benedetti A, Casini A.

Am J Pathol. 2006 Sep;169(3):846-60.PMID: 16936261 [PubMed - indexed for MEDLINE]Related articlesFree article

Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development.

Sekine K, Chen YR, Kojima N, Ogata K, Fukamizu A, Miyajima A.

EMBO J. 2007 Aug 8;26(15):3607-15. Epub 2007 Jul 12.PMID: 17627282 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease.

Valenti L, Fracanzani AL, Dongiovanni P, Santorelli G, Branchi A, Taioli E, Fiorelli G, Fargion S.

Gastroenterology. 2002 Feb;122(2):274-80.PMID: 11832442 [PubMed - indexed for MEDLINE]Related articles

Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice.

Altomonte J, Richter A, Harbaran S, Suriawinata J, Nakae J, Thung SN, Meseck M, Accili D, Dong H.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E718-28. Epub 2003 Jun 3.PMID: 12783775 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: possible role of vitamin A intake.

Musso G, Gambino R, De Michieli F, Biroli G, Premoli A, Pagano G, Bo S, Durazzo M, Cassader M.

Am J Clin Nutr. 2007 Sep;86(3):661-71.PMID: 17823431 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.

Samuel VT, Choi CS, Phillips TG, Romanelli AJ, Geisler JG, Bhanot S, McKay R, Monia B, Shutter JR, Lindberg RA, Shulman GI, Veniant MM.

Diabetes. 2006 Jul;55(7):2042-50.PMID: 16804074 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease.

Sakurai M, Takamura T, Ota T, Ando H, Akahori H, Kaji K, Sasaki M, Nakanuma Y, Miura K, Kaneko S.

J Gastroenterol. 2007 Apr;42(4):312-7. Epub 2007 Apr 26.PMID: 17464461 [PubMed - indexed for MEDLINE]Related articles

Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism.

Qu S, Altomonte J, Perdomo G, He J, Fan Y, Kamagate A, Meseck M, Dong HH.

Endocrinology. 2006 Dec;147(12):5641-52. Epub 2006 Sep 21.PMID: 16997836 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinguishing nonalcoholic steatohepatitis from fatty liver: serum-free fatty acids, insulin resistance, and serum lipoproteins.

Bookman ID, Pham J, Guindi M, Heathcote EJ.

Liver Int. 2006 Jun;26(5):566-71.PMID: 16762001 [PubMed - indexed for MEDLINE]Related articles

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.

Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF.

Cell Metab. 2008 Jul;8(1):65-76.PMID: 18590693 [PubMed - indexed for MEDLINE]Related articles

Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.

Nocito A, Dahm F, Jochum W, Jang JH, Georgiev P, Bader M, Renner EL, Clavien PA.

Gastroenterology. 2007 Aug;133(2):608-18. Epub 2007 May 21.PMID: 17681180 [PubMed - indexed for MEDLINE]Related articles

Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease.

Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, Kellum JM, Sanyal AJ.

Gastroenterology. 2008 Feb;134(2):568-76. Epub 2007 Oct 26.PMID: 18082745 [PubMed - indexed for MEDLINE]Related articles

Liver NF-kappaB and AP-1 DNA binding in obese patients.

Videla LA, Tapia G, Rodrigo R, Pettinelli P, Haim D, Santibañez C, Araya AV, Smok G, Csendes A, Gutierrez L, Rojas J, Castillo J, Korn O, Maluenda F, Díaz JC, Rencoret G, Poniachik J.

Obesity (Silver Spring). 2009 May;17(5):973-9. Epub 2009 Jan 22.PMID: 19165171 [PubMed - indexed for MEDLINE]Related articles

FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression.

Zhang W, Patil S, Chauhan B, Guo S, Powell DR, Le J, Klotsas A, Matika R, Xiao X, Franks R, Heidenreich KA, Sajan MP, Farese RV, Stolz DB, Tso P, Koo SH, Montminy M, Unterman TG.

J Biol Chem. 2006 Apr 14;281(15):10105-17. Epub 2006 Feb 21.PMID: 16492665 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.

Ota T, Takamura T, Kurita S, Matsuzawa N, Kita Y, Uno M, Akahori H, Misu H, Sakurai M, Zen Y, Nakanuma Y, Kaneko S.

Gastroenterology. 2007 Jan;132(1):282-93. Epub 2006 Oct 12.PMID: 17241878 [PubMed - indexed for MEDLINE]Related articles

Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis.

Zhang YL, Hernandez-Ono A, Siri P, Weisberg S, Conlon D, Graham MJ, Crooke RM, Huang LS, Ginsberg HN.

J Biol Chem. 2006 Dec 8;281(49):37603-15. Epub 2006 Sep 12.PMID: 16971390 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism.

Matsumoto M, Han S, Kitamura T, Accili D.

J Clin Invest. 2006 Sep;116(9):2464-72. Epub 2006 Aug 10.PMID: 16906224 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities.

Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA, Shiffman ML, Clore JN.

Gastroenterology. 2001 Apr;120(5):1183-92.PMID: 11266382 [PubMed - indexed for MEDLINE]Related articles