PubMed

The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment.

Martinuzzi E, Novelli G, Scotto M, Blancou P, Bach JM, Chaillous L, Bruno G, Chatenoud L, van Endert P, Mallone R.

Diabetes. 2008 May;57(5):1312-20. Epub 2008 Feb 27.PMID: 18305140 [PubMed - indexed for MEDLINE]Related articlesFree article

Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice.

Enée E, Martinuzzi E, Blancou P, Bach JM, Mallone R, van Endert P.

J Immunol. 2008 Apr 15;180(8):5430-8.PMID: 18390725 [PubMed - indexed for MEDLINE]Related articlesFree article

CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes.

Mallone R, Martinuzzi E, Blancou P, Novelli G, Afonso G, Dolz M, Bruno G, Chaillous L, Chatenoud L, Bach JM, van Endert P.

Diabetes. 2007 Mar;56(3):613-21.PMID: 17327428 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic and therapeutic control of diabetogenic CD8+ T cells.

Santamaria P.

Novartis Found Symp. 2008;292:130-6; discussion 136-45, 202-3.PMID: 19209463 [PubMed - indexed for MEDLINE]Related articles

Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery.

Baker C, Petrich de Marquesini LG, Bishop AJ, Hedges AJ, Dayan CM, Wong FS.

J Clin Immunol. 2008 Jul;28(4):350-60. Epub 2008 Feb 29.PMID: 18311511 [PubMed - indexed for MEDLINE]Related articles

Identification of novel IGRP epitopes targeted in type 1 diabetes patients.

Jarchum I, Nichol L, Trucco M, Santamaria P, DiLorenzo TP.

Clin Immunol. 2008 Jun;127(3):359-65. Epub 2008 Mar 20.PMID: 18358785 [PubMed - indexed for MEDLINE]Related articlesFree article

Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice.

Wong CP, Li L, Frelinger JA, Tisch R.

J Immunol. 2006 Feb 1;176(3):1637-44.PMID: 16424193 [PubMed - indexed for MEDLINE]Related articlesFree article

Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics.

Ejrnaes M, Videbaek N, Christen U, Cooke A, Michelsen BK, von Herrath M.

J Immunol. 2005 Mar 1;174(5):2746-55.PMID: 15728483 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of CD4+ T cell-specific epitopes of islet-specific glucose-6-phosphatase catalytic subunit-related protein: a novel beta cell autoantigen in type 1 diabetes.

Mukherjee R, Wagar D, Stephens TA, Lee-Chan E, Singh B.

J Immunol. 2005 May 1;174(9):5306-15.PMID: 15843527 [PubMed - indexed for MEDLINE]Related articlesFree article

Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes.

Ouyang Q, Standifer NE, Qin H, Gottlieb P, Verchere CB, Nepom GT, Tan R, Panagiotopoulos C.

Diabetes. 2006 Nov;55(11):3068-74.PMID: 17065344 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice.

Jarchum I, Baker JC, Yamada T, Takaki T, Marron MP, Serreze DV, DiLorenzo TP.

Diabetes. 2007 Oct;56(10):2551-60. Epub 2007 Jul 9.PMID: 17620420 [PubMed - indexed for MEDLINE]Related articlesFree article

Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men.

Unger WW, Pinkse GG, Mulder-van der Kracht S, van der Slik AR, Kester MG, Ossendorp F, Drijfhout JW, Serreze DV, Roep BO.

Ann N Y Acad Sci. 2007 Apr;1103:192-5. Epub 2007 Mar 21.PMID: 17376840 [PubMed - indexed for MEDLINE]Related articles

CD8 and cytotoxic T cells in type 1 diabetes.

Peakman M.

Novartis Found Symp. 2008;292:113-9; discussion 119-29, 202-3.PMID: 19203096 [PubMed - indexed for MEDLINE]Related articles

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.

Takaki T, Marron MP, Mathews CE, Guttmann ST, Bottino R, Trucco M, DiLorenzo TP, Serreze DV.

J Immunol. 2006 Mar 1;176(5):3257-65.PMID: 16493087 [PubMed - indexed for MEDLINE]Related articlesFree article

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

Krishnamurthy B, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, Colman PG, Harrison LC, Lew AM, Thomas HE, Kay TW.

J Clin Invest. 2006 Dec;116(12):3258-65.PMID: 17143333 [PubMed - indexed for MEDLINE]Related articlesFree article

CD8+ T lymphocytes specific for glutamic acid decarboxylase 90-98 epitope mediate diabetes in NOD SCID mouse.

Sévère S, Gauvrit A, Vu AT, Bach JM.

Mol Immunol. 2007 Apr;44(11):2950-60. Epub 2007 Mar 2.PMID: 17336387 [PubMed - indexed for MEDLINE]Related articles

MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activity.

Quinn A, McInerney MF, Sercarz EE.

J Immunol. 2001 Aug 1;167(3):1748-57.PMID: 11466400 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

Lieberman SM, Evans AM, Han B, Takaki T, Vinnitskaya Y, Caldwell JA, Serreze DV, Shabanowitz J, Hunt DF, Nathenson SG, Santamaria P, DiLorenzo TP.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8384-8. Epub 2003 Jun 18.PMID: 12815107 [PubMed - indexed for MEDLINE]Related articlesFree article

"Humanized" HLA transgenic NOD mice to identify pancreatic beta cell autoantigens of potential clinical relevance to type 1 diabetes.

Serreze DV, Marron MP, Dilorenzo TP.

Ann N Y Acad Sci. 2007 Apr;1103:103-11. Epub 2007 Mar 21.PMID: 17376821 [PubMed - indexed for MEDLINE]Related articles

Activation of CD8+ T lymphocytes in insulin-dependent diabetes mellitus.

Togun RA, Resetkova E, Kawai K, Enomoto T, Volpé R.

Clin Immunol Immunopathol. 1997 Mar;82(3):243-9.PMID: 9073547 [PubMed - indexed for MEDLINE]Related articles