PubMed

Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia.

Levin BE, Becker TC, Eiki J, Zhang BB, Dunn-Meynell AA.

Diabetes. 2008 May;57(5):1371-9. Epub 2008 Feb 21.PMID: 18292346 [PubMed - indexed for MEDLINE]Related articlesFree article

Caudal hindbrain lactate infusion alters glucokinase, SUR1, and neuronal substrate fuel transporter gene expression in the dorsal vagal complex, lateral hypothalamic area, and ventromedial nucleus hypothalamus of hypoglycemic male rats.

Vavaiya KV, Briski KP.

Brain Res. 2007 Oct 24;1176:62-70. Epub 2007 Aug 10.PMID: 17889836 [PubMed - indexed for MEDLINE]Related articles

Prior hypoglycemia enhances glucose responsiveness in some ventromedial hypothalamic glucosensing neurons.

Kang L, Sanders NM, Dunn-Meynell AA, Gaspers LD, Routh VH, Thomas AP, Levin BE.

Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R784-92. Epub 2007 Dec 19.PMID: 18094065 [PubMed - indexed for MEDLINE]Related articles

Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia.

McCrimmon RJ, Shaw M, Fan X, Cheng H, Ding Y, Vella MC, Zhou L, McNay EC, Sherwin RS.

Diabetes. 2008 Feb;57(2):444-50. Epub 2007 Oct 31.PMID: 17977955 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes.

Fan X, Ding Y, Brown S, Zhou L, Shaw M, Vella MC, Cheng H, McNay EC, Sherwin RS, McCrimmon RJ.

Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1702-8. Epub 2009 Apr 8.PMID: 19357294 [PubMed - indexed for MEDLINE]Related articles

Ibotenic acid lesions reduce noradrenergic activation in ventromedial hypothalamus during hypoglycemia.

Fugo KR, Lawson MA, Lee Beverly J.

Brain Res. 2006 Sep 21;1111(1):105-10. Epub 2006 Aug 14.PMID: 16905122 [PubMed - indexed for MEDLINE]Related articles

Effects of glucose and insulin on glucokinase activity in rat hypothalamus.

Sanz C, Roncero I, Vázquez P, Navas MA, Blázquez E.

J Endocrinol. 2007 May;193(2):259-67.PMID: 17470517 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia.

Chan O, Cheng H, Herzog R, Czyzyk D, Zhu W, Wang A, McCrimmon RJ, Seashore MR, Sherwin RS.

Diabetes. 2008 May;57(5):1363-70. Epub 2008 Mar 28.PMID: 18375441 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: impact of estradiol.

Vavaiya KV, Briski KP.

J Mol Neurosci. 2008 Feb;34(2):121-9. Epub 2007 Dec 15.PMID: 18084728 [PubMed - indexed for MEDLINE]Related articles

Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing.

Kang L, Dunn-Meynell AA, Routh VH, Gaspers LD, Nagata Y, Nishimura T, Eiki J, Zhang BB, Levin BE.

Diabetes. 2006 Feb;55(2):412-20. Erratum in: Diabetes. 2006 Mar;55(3):862. PMID: 16443775 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoglycemia-induced noradrenergic activation in the VMH is a result of decreased ambient glucose.

de Vries MG, Lawson MA, Beverly JL.

Am J Physiol Regul Integr Comp Physiol. 2005 Oct;289(4):R977-81.PMID: 16183631 [PubMed - indexed for MEDLINE]Related articles

Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding.

Dunn-Meynell AA, Sanders NM, Compton D, Becker TC, Eiki J, Zhang BB, Levin BE.

J Neurosci. 2009 May 27;29(21):7015-22.PMID: 19474328 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia.

Chan O, Lawson M, Zhu W, Beverly JL, Sherwin RS.

Diabetes. 2007 Apr;56(4):1120-6. Epub 2007 Jan 24.PMID: 17251273 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats.

McCrimmon RJ, Evans ML, Fan X, McNay EC, Chan O, Ding Y, Zhu W, Gram DX, Sherwin RS.

Diabetes. 2005 Nov;54(11):3169-74.PMID: 16249441 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of caudal hindbrain lactate infusion on insulin-induced hypoglycemia and neuronal substrate transporter glucokinase and sulfonylurea receptor-1 gene expression in the ovariectomized female rat dorsal vagal complex: Impact of estradiol.

Vavaiya KV, Briski KP.

J Neurosci Res. 2008 Feb 15;86(3):694-701.PMID: 17941059 [PubMed - indexed for MEDLINE]Related articles

Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus.

McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ, Sherwin RS.

Diabetes. 2004 Aug;53(8):1953-8.PMID: 15277372 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia.

Chan O, Zhu W, Ding Y, McCrimmon RJ, Sherwin RS.

Diabetes. 2006 Apr;55(4):1080-7.PMID: 16567532 [PubMed - indexed for MEDLINE]Related articlesFree article

Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

Borg WP, During MJ, Sherwin RS, Borg MA, Brines ML, Shulman GI.

J Clin Invest. 1994 Apr;93(4):1677-82.PMID: 8163668 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons.

Dunn-Meynell AA, Routh VH, Kang L, Gaspers L, Levin BE.

Diabetes. 2002 Jul;51(7):2056-65.PMID: 12086933 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses.

Evans ML, McCrimmon RJ, Flanagan DE, Keshavarz T, Fan X, McNay EC, Jacob RJ, Sherwin RS.

Diabetes. 2004 Oct;53(10):2542-51.PMID: 15448082 [PubMed - indexed for MEDLINE]Related articlesFree article