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Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance.

Nair KS, Bigelow ML, Asmann YW, Chow LS, Coenen-Schimke JM, Klaus KA, Guo ZK, Sreekumar R, Irving BA.

Diabetes. 2008 May;57(5):1166-75. Epub 2008 Feb 19. Erratum in: Diabetes. 2009 Mar;58(3):770. PMID: 18285554 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia.

Asmann YW, Stump CS, Short KR, Coenen-Schimke JM, Guo Z, Bigelow ML, Nair KS.

Diabetes. 2006 Dec;55(12):3309-19.PMID: 17130474 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of insulin deprivation on muscle mitochondrial ATP production and gene transcript levels in type 1 diabetic subjects.

Karakelides H, Asmann YW, Bigelow ML, Short KR, Dhatariya K, Coenen-Schimke J, Kahl J, Mukhopadhyay D, Nair KS.

Diabetes. 2007 Nov;56(11):2683-9. Epub 2007 Jul 27.PMID: 17660267 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.

Petersen KF, Dufour S, Shulman GI.

PLoS Med. 2005 Sep;2(9):e233. Epub 2005 Aug 16.PMID: 16089501 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.

Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI.

N Engl J Med. 2004 Feb 12;350(7):664-71.PMID: 14960743 [PubMed - indexed for MEDLINE]Related articlesFree article

Intact proinsulin, des 31,32 proinsulin, and specific insulin concentrations among nondiabetic and diabetic subjects in populations at varying risk of type 2 diabetes.

Nagi DK, Knowler WC, Mohamed-Ali V, Bennett PH, Yudkin JS.

Diabetes Care. 1998 Jan;21(1):127-33.PMID: 9538983 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance.

Holloszy JO.

Am J Clin Nutr. 2009 Jan;89(1):463S-6S. Epub 2008 Dec 3. Review.PMID: 19056574 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial function in skeletal muscle is normal and unrelated to insulin action in young men born with low birth weight.

Brøns C, Jensen CB, Storgaard H, Alibegovic A, Jacobsen S, Nilsson E, Astrup A, Quistorff B, Vaag A.

J Clin Endocrinol Metab. 2008 Oct;93(10):3885-92. Epub 2008 Jul 15.PMID: 18628517 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants.

Abdul-Ghani MA, Jani R, Chavez A, Molina-Carrion M, Tripathy D, Defronzo RA.

Diabetologia. 2009 Apr;52(4):574-82. Epub 2009 Jan 30.PMID: 19183935 [PubMed - indexed for MEDLINE]Related articles

Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status.

Bruce CR, Anderson MJ, Carey AL, Newman DG, Bonen A, Kriketos AD, Cooney GJ, Hawley JA.

J Clin Endocrinol Metab. 2003 Nov;88(11):5444-51.PMID: 14602787 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus.

Mensink M, Hesselink MK, Russell AP, Schaart G, Sels JP, Schrauwen P.

Int J Obes (Lond). 2007 Aug;31(8):1302-10. Epub 2007 Feb 20.PMID: 17310221 [PubMed - indexed for MEDLINE]Related articles

Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts.

Stump CS, Short KR, Bigelow ML, Schimke JM, Nair KS.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7996-8001. Epub 2003 Jun 13.PMID: 12808136 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men.

Chandalia M, Abate N, Garg A, Stray-Gundersen J, Grundy SM.

J Clin Endocrinol Metab. 1999 Jul;84(7):2329-35.PMID: 10404798 [PubMed - indexed for MEDLINE]Related articlesFree article

Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians.

Raji A, Seely EW, Arky RA, Simonson DC.

J Clin Endocrinol Metab. 2001 Nov;86(11):5366-71.PMID: 11701707 [PubMed - indexed for MEDLINE]Related articlesFree article

Exaggerated early insulin release and insulin resistance in a diabetes-prone population: a metabolic comparison of Pima Indians and Caucasians.

Lillioja S, Nyomba BL, Saad MF, Ferraro R, Castillo C, Bennett PH, Bogardus C.

J Clin Endocrinol Metab. 1991 Oct;73(4):866-76.PMID: 1890157 [PubMed - indexed for MEDLINE]Related articles

Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes.

Szendroedi J, Schmid AI, Chmelik M, Toth C, Brehm A, Krssak M, Nowotny P, Wolzt M, Waldhausl W, Roden M.

PLoS Med. 2007 May;4(5):e154.PMID: 17472434 [PubMed - indexed for MEDLINE]Related articlesFree article

Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with Type II diabetes.

Levin K, Daa Schroeder H, Alford FP, Beck-Nielsen H.

Diabetologia. 2001 Jul;44(7):824-33.PMID: 11508266 [PubMed - indexed for MEDLINE]Related articles

Effect of pioglitazone on insulin sensitivity, vascular function and cardiovascular inflammatory markers in insulin-resistant non-diabetic Asian Indians.

Raji A, Gerhard-Herman MD, Williams JS, O'connor ME, Simonson DC.

Diabet Med. 2006 May;23(5):537-43.PMID: 16681563 [PubMed - indexed for MEDLINE]Related articles

Insulin regulation of mitochondrial proteins and oxidative phosphorylation in human muscle.

Boirie Y.

Trends Endocrinol Metab. 2003 Nov;14(9):393-4. Review.PMID: 14580754 [PubMed - indexed for MEDLINE]Related articles

Relationship of hepatic and peripheral insulin resistance with plasminogen activator inhibitor-1 in Pima Indians.

Nagi DK, Tracy R, Pratley R.

Metabolism. 1996 Oct;45(10):1243-7.PMID: 8843179 [PubMed - indexed for MEDLINE]Related articles