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    Results: 1 to 20 of 1489

    1.

    Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.

    Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.

    Diabetes. 2008 May;57(5):1195-204. Epub 2008 Feb 14.PMID: 18276765 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation.

    Chavez JA, Roach WG, Keller SR, Lane WS, Lienhard GE.

    J Biol Chem. 2008 Apr 4;283(14):9187-95. Epub 2008 Feb 7.PMID: 18258599 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic.

    Thong FS, Bilan PJ, Klip A.

    Diabetes. 2007 Feb;56(2):414-23.PMID: 17259386 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160.

    Ramm G, Larance M, Guilhaus M, James DE.

    J Biol Chem. 2006 Sep 29;281(39):29174-80. Epub 2006 Jul 31.PMID: 16880201 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

    Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

    Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.PMID: 17068144 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects.

    Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H.

    Diabetes. 2005 Jun;54(6):1692-7.PMID: 15919790 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes.

    Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP.

    Biochem J. 2008 May 1;411(3):647-55.PMID: 18215134 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.

    Ishikura S, Klip A.

    Am J Physiol Cell Physiol. 2008 Oct;295(4):C1016-25. Epub 2008 Aug 13.PMID: 18701652 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.

    Mîinea CP, Sano H, Kane S, Sano E, Fukuda M, Peränen J, Lane WS, Lienhard GE.

    Biochem J. 2005 Oct 1;391(Pt 1):87-93.PMID: 15971998 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion.

    Bouzakri K, Ribaux P, Halban PA.

    J Biol Chem. 2009 Oct 9;284(41):27892-8. Epub 2009 Aug 18.PMID: 19690174 [PubMed - indexed for MEDLINE]Related articles

    11.

    Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.

    Frøsig C, Rose AJ, Treebak JT, Kiens B, Richter EA, Wojtaszewski JF.

    Diabetes. 2007 Aug;56(8):2093-102. Epub 2007 May 18.PMID: 17513702 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function.

    Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P, Arnoletti E, Ghè C, Volante M, Papotti M, Muccioli G, Ghigo E.

    Diabetes. 2008 Apr;57(4):967-79. Epub 2007 Dec 27.PMID: 18162507 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.

    Taylor EB, An D, Kramer HF, Yu H, Fujii NL, Roeckl KS, Bowles N, Hirshman MF, Xie J, Feener EP, Goodyear LJ.

    J Biol Chem. 2008 Apr 11;283(15):9787-96. Epub 2008 Feb 13.PMID: 18276596 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt.

    Yano T, Liu Z, Donovan J, Thomas MK, Habener JF.

    Diabetes. 2007 Dec;56(12):2946-57. Epub 2007 Sep 18.PMID: 17878289 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Calmodulin binds to the Rab GTPase activating protein required for insulin-stimulated GLUT4 translocation.

    Kane S, Lienhard GE.

    Biochem Biophys Res Commun. 2005 Sep 16;335(1):175-80.PMID: 16055084 [PubMed - indexed for MEDLINE]Related articles

    16.

    Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.

    Fontés G, Semache M, Hagman DK, Tremblay C, Shah R, Rhodes CJ, Rutter J, Poitout V.

    Diabetes. 2009 Sep;58(9):2048-58. Epub 2009 Jun 5.PMID: 19502418 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation.

    Sano H, Kane S, Sano E, Mîinea CP, Asara JM, Lane WS, Garner CW, Lienhard GE.

    J Biol Chem. 2003 Apr 25;278(17):14599-602. Epub 2003 Mar 11.PMID: 12637568 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake.

    Green CJ, Göransson O, Kular GS, Leslie NR, Gray A, Alessi DR, Sakamoto K, Hundal HS.

    J Biol Chem. 2008 Oct 10;283(41):27653-67. Epub 2008 Jul 31.PMID: 18669636 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.

    Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP.

    J Biol Chem. 2005 Jun 3;280(22):21622-8. Epub 2005 Mar 30.PMID: 15799971 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells.

    Ishikura S, Bilan PJ, Klip A.

    Biochem Biophys Res Commun. 2007 Feb 23;353(4):1074-9. Epub 2006 Dec 27.PMID: 17208202 [PubMed - indexed for MEDLINE]Related articles

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