PubMed

Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.

Inoue M, Ma L, Aoki J, Chun J, Ueda H.

Mol Pain. 2008 Feb 8;4:6.PMID: 18261210 [PubMed - indexed for MEDLINE]Related articlesFree article

Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.

Inoue M, Xie W, Matsushita Y, Chun J, Aoki J, Ueda H.

Neuroscience. 2008 Mar 18;152(2):296-8. Epub 2008 Jan 9.PMID: 18280050 [PubMed - indexed for MEDLINE]Related articles

Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.

Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H.

Mol Pain. 2009 Nov 13;5:64.PMID: 19912636 [PubMed - indexed for MEDLINE]Related articlesFree article

Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain.

Inoue M, Ma L, Aoki J, Ueda H.

J Neurochem. 2008 Dec;107(6):1556-65. Epub 2008 Nov 5.PMID: 19014389 [PubMed - indexed for MEDLINE]Related articles

Two pathways for lysophosphatidic acid production.

Aoki J, Inoue A, Okudaira S.

Biochim Biophys Acta. 2008 Sep;1781(9):513-8. Epub 2008 Jun 24. Review.PMID: 18621144 [PubMed - indexed for MEDLINE]Related articles

Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-induced Neuropathic Pain.

Ma L, Uchida H, Nagai J, Inoue M, Aoki J, Ueda H.

J Pharmacol Exp Ther. 2010 Feb 1. [Epub ahead of print]PMID: 20123931 [PubMed - as supplied by publisher]Related articlesFree article

ATX-LPA receptor axis in inflammation and cancer.

Liu S, Murph M, Panupinthu N, Mills GB.

Cell Cycle. 2009 Nov 15;8(22):3695-701. Epub 2009 Nov 27. Review.PMID: 19855166 [PubMed - indexed for MEDLINE]Related articles

Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid: ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia.

Uchida H, Matsumoto M, Ueda H.

Neurochem Int. 2009 Mar-Apr;54(3-4):215-21. Epub 2008 Dec 7.PMID: 19111589 [PubMed - indexed for MEDLINE]Related articles

Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice.

Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S.

Anesth Analg. 2009 Oct;109(4):1305-11.PMID: 19762761 [PubMed - indexed for MEDLINE]Related articles

Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions.

Nakasaki T, Tanaka T, Okudaira S, Hirosawa M, Umemoto E, Otani K, Jin S, Bai Z, Hayasaka H, Fukui Y, Aozasa K, Fujita N, Tsuruo T, Ozono K, Aoki J, Miyasaka M.

Am J Pathol. 2008 Nov;173(5):1566-76. Epub 2008 Sep 25.PMID: 18818380 [PubMed - indexed for MEDLINE]Related articlesFree article

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development.

van Meeteren LA, Ruurs P, Stortelers C, Bouwman P, van Rooijen MA, Pradère JP, Pettit TR, Wakelam MJ, Saulnier-Blache JS, Mummery CL, Moolenaar WH, Jonkers J.

Mol Cell Biol. 2006 Jul;26(13):5015-22.PMID: 16782887 [PubMed - indexed for MEDLINE]Related articlesFree article

Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.

Hama K, Aoki J, Fukaya M, Kishi Y, Sakai T, Suzuki R, Ohta H, Yamori T, Watanabe M, Chun J, Arai H.

J Biol Chem. 2004 Apr 23;279(17):17634-9. Epub 2004 Jan 26.PMID: 14744855 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced nerve injury-induced neuropathic pain in kinin B1 receptor knock-out mice.

Ferreira J, Beirith A, Mori MA, Araújo RC, Bader M, Pesquero JB, Calixto JB.

J Neurosci. 2005 Mar 2;25(9):2405-12.PMID: 15745967 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic potential of autotaxin/lysophospholipase d inhibitors.

Federico L, Pamuklar Z, Smyth SS, Morris AJ.

Curr Drug Targets. 2008 Aug;9(8):698-708. Review.PMID: 18691016 [PubMed - indexed for MEDLINE]Related articles

Regulation and biological activities of the autotaxin-LPA axis.

van Meeteren LA, Moolenaar WH.

Prog Lipid Res. 2007 Mar;46(2):145-60. Epub 2007 Mar 16. Review.PMID: 17459484 [PubMed - indexed for MEDLINE]Related articles

Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.

Tanaka M, Okudaira S, Kishi Y, Ohkawa R, Iseki S, Ota M, Noji S, Yatomi Y, Aoki J, Arai H.

J Biol Chem. 2006 Sep 1;281(35):25822-30. Epub 2006 Jul 6.PMID: 16829511 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain.

Inoue M, Yamaguchi A, Kawakami M, Chun J, Ueda H.

Mol Pain. 2006 Aug 16;2:25.PMID: 16914035 [PubMed - indexed for MEDLINE]Related articlesFree article

Autotaxin structure-activity relationships revealed through lysophosphatidylcholine analogs.

North EJ, Osborne DA, Bridson PK, Baker DL, Parrill AL.

Bioorg Med Chem. 2009 May 1;17(9):3433-42. Epub 2009 Mar 21.PMID: 19345587 [PubMed - indexed for MEDLINE]Related articles

Nerve injury induces a tonic bilateral mu-opioid receptor-mediated inhibitory effect on mechanical allodynia in mice.

Mansikka H, Zhao C, Sheth RN, Sora I, Uhl G, Raja SN.

Anesthesiology. 2004 Apr;100(4):912-21.PMID: 15087627 [PubMed - indexed for MEDLINE]Related articlesFree article

Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood.

Endo T, Kano K, Motoki R, Hama K, Okudaira S, Ishida M, Ogiso H, Tanaka M, Matsuki N, Taguchi R, Kanai M, Shibasaki M, Arai H, Aoki J.

J Biochem. 2009 Aug;146(2):283-93. Epub 2009 May 4.PMID: 19416959 [PubMed - indexed for MEDLINE]Related articles