PubMed

Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.

Chugh P, Bradel-Tretheway B, Monteiro-Filho CM, Planelles V, Maggirwar SB, Dewhurst S, Kim B.

Retrovirology. 2008 Jan 31;5:11.PMID: 18237430 [PubMed - indexed for MEDLINE]Related articlesFree article

Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.

Chugh P, Fan S, Planelles V, Maggirwar SB, Dewhurst S, Kim B.

J Mol Biol. 2007 Feb 9;366(1):67-81. Epub 2006 Nov 10.PMID: 17157319 [PubMed - indexed for MEDLINE]Related articles

Constitutive activation of phosphatidylinositol 3-kinase signaling pathway down-regulates TLR4-mediated tumor necrosis factor-alpha release in alveolar macrophages from asymptomatic HIV-positive persons in vitro.

Tachado SD, Li X, Swan K, Patel N, Koziel H.

J Biol Chem. 2008 Nov 28;283(48):33191-8. Epub 2008 Sep 30.PMID: 18826950 [PubMed - indexed for MEDLINE]Related articlesFree article

Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors.

Festuccia C, Gravina GL, Muzi P, Millimaggi D, Dolo V, Vicentini C, Bologna M.

Prostate. 2008 Jun 15;68(9):965-74.PMID: 18361408 [PubMed - indexed for MEDLINE]Related articles

HIV-1 infection induces changes in expression of cellular splicing factors that regulate alternative viral splicing and virus production in macrophages.

Dowling D, Nasr-Esfahani S, Tan CH, O'Brien K, Howard JL, Jans DA, Purcell DF, Stoltzfus CM, Sonza S.

Retrovirology. 2008 Feb 4;5:18.PMID: 18241354 [PubMed - indexed for MEDLINE]Related articlesFree article

RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.

Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, Habib AA.

Cancer Res. 2009 May 15;69(10):4107-11. Epub 2009 May 12.PMID: 19435890 [PubMed - indexed for MEDLINE]Related articles

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications.

Carnero A, Blanco-Aparicio C, Renner O, Link W, Leal JF.

Curr Cancer Drug Targets. 2008 May;8(3):187-98. Review.PMID: 18473732 [PubMed - indexed for MEDLINE]Related articles

Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages.

Cui M, Huang Y, Zhao Y, Zheng J.

J Immunol. 2008 Jan 15;180(2):898-906.PMID: 18178829 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages.

Papakonstanti EA, Zwaenepoel O, Bilancio A, Burns E, Nock GE, Houseman B, Shokat K, Ridley AJ, Vanhaesebroeck B.

J Cell Sci. 2008 Dec 15;121(Pt 24):4124-33. Epub 2008 Nov 25.PMID: 19033389 [PubMed - indexed for MEDLINE]Related articlesFree article

Akt-mediated activation of HIF-1 in pulmonary vascular endothelial cells by S-nitrosoglutathione.

Carver DJ, Gaston B, Deronde K, Palmer LA.

Am J Respir Cell Mol Biol. 2007 Sep;37(3):255-63. Epub 2007 May 31.PMID: 17541013 [PubMed - indexed for MEDLINE]Related articlesFree article

Human alveolar macrophages are deficient in PTEN. The role of endogenous oxidants.

Flaherty DM, Monick MM, Hinde SL.

J Biol Chem. 2006 Feb 24;281(8):5058-64. Epub 2005 Dec 21.PMID: 16371363 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells.

Zhu N, Gu L, Li F, Zhou M.

Mol Cancer Ther. 2008 May;7(5):1101-9.PMID: 18483299 [PubMed - indexed for MEDLINE]Related articlesFree article

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells.

Marty B, Maire V, Gravier E, Rigaill G, Vincent-Salomon A, Kappler M, Lebigot I, Djelti F, Tourdès A, Gestraud P, Hupé P, Barillot E, Cruzalegui F, Tucker GC, Stern MH, Thiery JP, Hickman JA, Dubois T.

Breast Cancer Res. 2008;10(6):R101. Epub 2008 Dec 3.PMID: 19055754 [PubMed - indexed for MEDLINE]Related articlesFree article

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability.

Silva A, Yunes JA, Cardoso BA, Martins LR, Jotta PY, Abecasis M, Nowill AE, Leslie NR, Cardoso AA, Barata JT.

J Clin Invest. 2008 Nov;118(11):3762-74. Epub 2008 Oct 1.PMID: 18830414 [PubMed - indexed for MEDLINE]Related articlesFree article

Reciprocal regulation of Notch and PI3K/Akt signalling in T-ALL cells in vitro.

Calzavara E, Chiaramonte R, Cesana D, Basile A, Sherbet GV, Comi P.

J Cell Biochem. 2008 Apr 1;103(5):1405-12.PMID: 17849443 [PubMed - indexed for MEDLINE]Related articles

Temporal PTEN inactivation causes proliferation of saphenous vein smooth muscle cells of human CABG conduits.

Mitra AK, Jia G, Gangahar DM, Agrawal DK.

J Cell Mol Med. 2009 Jan;13(1):177-87. Epub 2008 Mar 19.PMID: 18363844 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages.

Sun J, Ramnath RD, Tamizhselvi R, Bhatia M.

FASEB J. 2009 Apr;23(4):997-1010. Epub 2008 Nov 24.PMID: 19029199 [PubMed - indexed for MEDLINE]Related articles

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.

Chiarini F, Del Sole M, Mongiorgi S, Gaboardi GC, Cappellini A, Mantovani I, Follo MY, McCubrey JA, Martelli AM.

Leukemia. 2008 Jun;22(6):1106-16. Epub 2008 Apr 3.PMID: 18385752 [PubMed - indexed for MEDLINE]Related articles

Hitting HIV where it hides.

Dayton AI.

Retrovirology. 2008 Feb 1;5:15.PMID: 18241337 [PubMed - indexed for MEDLINE]Related articlesFree article

Hexamethylbisacetamide and disruption of human immunodeficiency virus type 1 latency in CD4(+) T cells.

Choudhary SK, Archin NM, Margolis DM.

J Infect Dis. 2008 Apr 15;197(8):1162-70.PMID: 18419522 [PubMed - indexed for MEDLINE]Related articles