PubMed

Topical rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model.

Rauktys A, Lee N, Lee L, Dabora SL.

BMC Dermatol. 2008 Jan 28;8:1.PMID: 18226258 [PubMed - indexed for MEDLINE]Related articlesFree article

Tuberous sclerosis preclinical studies: timing of treatment, combination of a rapamycin analog (CCI-779) and interferon-gamma, and comparison of rapamycin to CCI-779.

Messina MP, Rauktys A, Lee L, Dabora SL.

BMC Pharmacol. 2007 Nov 6;7:14.PMID: 17986349 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models.

Lee N, Woodrum CL, Nobil AM, Rauktys AE, Messina MP, Dabora SL.

BMC Pharmacol. 2009 Apr 15;9:8.PMID: 19368729 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination of a rapamycin analog (CCI-779) and interferon-gamma is more effective than single agents in treating a mouse model of tuberous sclerosis complex.

Lee L, Sudentas P, Dabora SL.

Genes Chromosomes Cancer. 2006 Oct;45(10):933-44.PMID: 16845661 [PubMed - indexed for MEDLINE]Related articles

Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models.

Lee L, Sudentas P, Donohue B, Asrican K, Worku A, Walker V, Sun Y, Schmidt K, Albert MS, El-Hashemite N, Lader AS, Onda H, Zhang H, Kwiatkowski DJ, Dabora SL.

Genes Chromosomes Cancer. 2005 Mar;42(3):213-27.PMID: 15578690 [PubMed - indexed for MEDLINE]Related articles

Effects of rapamycin in the Eker rat model of tuberous sclerosis complex.

Kenerson H, Dundon TA, Yeung RS.

Pediatr Res. 2005 Jan;57(1):67-75. Epub 2004 Nov 19.PMID: 15557109 [PubMed - indexed for MEDLINE]Related articles

Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function.

Meikle L, Pollizzi K, Egnor A, Kramvis I, Lane H, Sahin M, Kwiatkowski DJ.

J Neurosci. 2008 May 21;28(21):5422-32.PMID: 18495876 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

Zeng LH, Xu L, Gutmann DH, Wong M.

Ann Neurol. 2008 Apr;63(4):444-53.PMID: 18389497 [PubMed - indexed for MEDLINE]Related articles

The mTOR inhibitor rapamycin significantly improves facial angiofibroma lesions in a patient with tuberous sclerosis.

Hofbauer GF, Marcollo-Pini A, Corsenca A, Kistler AD, French LE, Wüthrich RP, Serra AL.

Br J Dermatol. 2008 Aug;159(2):473-5. Epub 2008 Jun 28.PMID: 18547304 [PubMed - indexed for MEDLINE]Related articles

Recent advances in neurobiology of Tuberous Sclerosis Complex.

Napolioni V, Moavero R, Curatolo P.

Brain Dev. 2009 Feb;31(2):104-13. Epub 2008 Nov 22. Review.PMID: 19028034 [PubMed - indexed for MEDLINE]Related articles

Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis.

Pollizzi K, Malinowska-Kolodziej I, Stumm M, Lane H, Kwiatkowski D.

Mol Cancer. 2009 Jun 15;8:38.PMID: 19527517 [PubMed - indexed for MEDLINE]Related articlesFree article

Current management of tuberous sclerosis complex.

Krueger DA, Franz DN.

Paediatr Drugs. 2008;10(5):299-313. Review.PMID: 18754697 [PubMed - indexed for MEDLINE]Related articles

Therapeutic targeting of mTOR in tuberous sclerosis.

Sampson JR.

Biochem Soc Trans. 2009 Feb;37(Pt 1):259-64. Review.PMID: 19143643 [PubMed - indexed for MEDLINE]Related articles

Tuberous sclerosis complex: advances in diagnosis, genetics, and management.

Schwartz RA, Fernández G, Kotulska K, Jóźwiak S.

J Am Acad Dermatol. 2007 Aug;57(2):189-202. Review.PMID: 17637444 [PubMed - indexed for MEDLINE]Related articles

Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors.

Granville CA, Warfel N, Tsurutani J, Hollander MC, Robertson M, Fox SD, Veenstra TD, Issaq HJ, Linnoila RI, Dennis PA.

Clin Cancer Res. 2007 Apr 1;13(7):2281-9.PMID: 17404113 [PubMed - indexed for MEDLINE]Related articlesFree article

A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer.

Amornphimoltham P, Patel V, Leelahavanichkul K, Abraham RT, Gutkind JS.

Cancer Res. 2008 Feb 15;68(4):1144-53.PMID: 18281490 [PubMed - indexed for MEDLINE]Related articlesFree article

Regression of subependymal giant cell astrocytoma with rapamycin in tuberous sclerosis complex.

Koenig MK, Butler IJ, Northrup H.

J Child Neurol. 2008 Oct;23(10):1238-9.PMID: 18952591 [PubMed - indexed for MEDLINE]Related articles

Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment.

Jozwiak J, Jozwiak S, Oldak M.

Med Res Rev. 2006 Mar;26(2):160-80. Review.PMID: 16329102 [PubMed - indexed for MEDLINE]Related articles

Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma.

Lu KH, Wu W, Dave B, Slomovitz BM, Burke TW, Munsell MF, Broaddus RR, Walker CL.

Clin Cancer Res. 2008 May 1;14(9):2543-50.PMID: 18451215 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapamycin causes regression of astrocytomas in tuberous sclerosis complex.

Franz DN, Leonard J, Tudor C, Chuck G, Care M, Sethuraman G, Dinopoulos A, Thomas G, Crone KR.

Ann Neurol. 2006 Mar;59(3):490-8.PMID: 16453317 [PubMed - indexed for MEDLINE]Related articles