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Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal.

Chiu JD, Richey JM, Harrison LN, Zuniga E, Kolka CM, Kirkman E, Ellmerer M, Bergman RN.

Diabetes. 2008 Apr;57(4):828-35. Epub 2008 Jan 25.PMID: 18223011 [PubMed - indexed for MEDLINE]Related articlesFree article

New concepts in extracellular signaling for insulin action: the single gateway hypothesis.

Bergman RN.

Recent Prog Horm Res. 1997;52:359-85; discussion 385-7. Review.PMID: 9238859 [PubMed - indexed for MEDLINE]Related articles

Mode of transcapillary transport of insulin and insulin analog NN304 in dog hindlimb: evidence for passive diffusion.

Hamilton-Wessler M, Ader M, Dea MK, Moore D, Loftager M, Markussen J, Bergman RN.

Diabetes. 2002 Mar;51(3):574-82.PMID: 11872653 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph.

Poulin RA, Steil GM, Moore DM, Ader M, Bergman RN.

Diabetes. 1994 Feb;43(2):180-90.PMID: 8288041 [PubMed - indexed for MEDLINE]Related articles

Interstitial muscle insulin and glucose levels in normal and insulin-resistant Zucker rats.

Holmäng A, Mimura K, Björntorp P, Lönnroth P.

Diabetes. 1997 Nov;46(11):1799-804.PMID: 9356029 [PubMed - indexed for MEDLINE]Related articles

Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo.

Clerk LH, Rattigan S, Clark MG.

Diabetes. 2002 Apr;51(4):1138-45.PMID: 11916937 [PubMed - indexed for MEDLINE]Related articlesFree article

Active role for the vasculature in the delivery of insulin to skeletal muscle.

Vincent MA, Clerk LH, Rattigan S, Clark MG, Barrett EJ.

Clin Exp Pharmacol Physiol. 2005 Apr;32(4):302-7. Review.PMID: 15810996 [PubMed - indexed for MEDLINE]Related articles

The role of the transcapillary insulin transport in the efficiency of insulin action: studies with glucose clamps and the minimal model.

Bergman RN, Yang YJ, Hope ID, Ader M.

Horm Metab Res Suppl. 1990;24:49-56. Review.PMID: 2272626 [PubMed - indexed for MEDLINE]Related articles

Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha.

Youd JM, Rattigan S, Clark MG.

Diabetes. 2000 Nov;49(11):1904-9.PMID: 11078458 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment.

Coggins M, Lindner J, Rattigan S, Jahn L, Fasy E, Kaul S, Barrett E.

Diabetes. 2001 Dec;50(12):2682-90.PMID: 11723050 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise training improves insulin-mediated capillary recruitment in association with glucose uptake in rat hindlimb.

Rattigan S, Wallis MG, Youd JM, Clark MG.

Diabetes. 2001 Dec;50(12):2659-65.PMID: 11723047 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.

Rattigan S, Clark MG, Barrett EJ.

Diabetes. 1999 Mar;48(3):564-9.PMID: 10078557 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-mediated capillary recruitment in skeletal muscle: is this a mediator of insulin action on glucose metabolism?

Rattigan S, Barrett EJ, Clark MG.

Curr Diab Rep. 2003 Jun;3(3):195-200. Review.PMID: 12762965 [PubMed - indexed for MEDLINE]Related articles

Delayed onset of insulin activation of the insulin receptor kinase in vivo in human skeletal muscle.

Freidenberg GR, Suter S, Henry RR, Nolan J, Reichart D, Olefsky JM.

Diabetes. 1994 Jan;43(1):118-26.PMID: 8262308 [PubMed - indexed for MEDLINE]Related articles

Local methacholine but not bradykinin potentiates insulin-mediated glucose uptake in muscle in vivo by augmenting capillary recruitment.

Mahajan H, Richards SM, Rattigan S, Clark MG.

Diabetologia. 2004 Dec;47(12):2226-34. Epub 2004 Dec 16.PMID: 15602653 [PubMed - indexed for MEDLINE]Related articles

Dose-response relationship between lymph insulin and glucose uptake reveals enhanced insulin sensitivity of peripheral tissues.

Yang YJ, Hope I, Ader M, Poulin RA, Bergman RN.

Diabetes. 1992 Feb;41(2):241-53. Erratum in: Diabetes 1997 Apr;46(4):731. PMID: 1733816 [PubMed - indexed for MEDLINE]Related articles

Effect of metformin on the vascular and glucose metabolic actions of insulin in hypertensive rats.

Santuré M, Pitre M, Gaudreault N, Marette A, Nadeau A, Bachelard H.

Am J Physiol Gastrointest Liver Physiol. 2000 May;278(5):G682-92.PMID: 10801260 [PubMed - indexed for MEDLINE]Related articlesFree article

Experimental hyperlipidemia dramatically reduces access of insulin to canine skeletal muscle.

Chiu JD, Kolka CM, Richey JM, Harrison LN, Zuniga E, Kirkman EL, Bergman RN.

Obesity (Silver Spring). 2009 Aug;17(8):1486-92. Epub 2009 Jun 11.PMID: 19521354 [PubMed - indexed for MEDLINE]Related articles

Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.

Eggleston EM, Jahn LA, Barrett EJ.

Diabetes. 2007 Dec;56(12):2958-63. Epub 2007 Aug 24.PMID: 17720897 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin sensitivity of muscle capillary recruitment in vivo.

Zhang L, Vincent MA, Richards SM, Clerk LH, Rattigan S, Clark MG, Barrett EJ.

Diabetes. 2004 Feb;53(2):447-53.PMID: 14747297 [PubMed - indexed for MEDLINE]Related articlesFree article