PubMed

Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells.

Pan Y, Weinman EJ, Dai JL.

Breast Cancer Res. 2008;10(1):R5. Epub 2008 Jan 11.PMID: 18190691 [PubMed - indexed for MEDLINE]Related articlesFree article

NHERF1: molecular brake on the PI3K pathway in breast cancer.

Georgescu MM.

Breast Cancer Res. 2008;10(2):106. Epub 2008 Apr 18.PMID: 18430260 [PubMed - indexed for MEDLINE]Related articlesFree article

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.

Takahashi Y, Morales FC, Kreimann EL, Georgescu MM.

EMBO J. 2006 Feb 22;25(4):910-20. Epub 2006 Feb 2.PMID: 16456542 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1).

Pan Y, Wang L, Dai JL.

Breast Cancer Res. 2006;8(6):R63.PMID: 17078868 [PubMed - indexed for MEDLINE]Related articlesFree article

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.PMID: 16854453 [PubMed - indexed for MEDLINE]Related articles

Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway.

DeGraffenried LA, Fulcher L, Friedrichs WE, Grünwald V, Ray RB, Hidalgo M.

Ann Oncol. 2004 Oct;15(10):1510-6.PMID: 15367412 [PubMed - indexed for MEDLINE]Related articlesFree article

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells.

Marty B, Maire V, Gravier E, Rigaill G, Vincent-Salomon A, Kappler M, Lebigot I, Djelti F, Tourdès A, Gestraud P, Hupé P, Barillot E, Cruzalegui F, Tucker GC, Stern MH, Thiery JP, Hickman JA, Dubois T.

Breast Cancer Res. 2008;10(6):R101. Epub 2008 Dec 3.PMID: 19055754 [PubMed - indexed for MEDLINE]Related articlesFree article

Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma.

Tokunaga E, Oki E, Kimura Y, Yamanaka T, Egashira A, Nishida K, Koga T, Morita M, Kakeji Y, Maehara Y.

Breast Cancer Res Treat. 2007 Mar;101(3):249-57. Epub 2006 Sep 28.PMID: 17006756 [PubMed - indexed for MEDLINE]Related articles

Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase.

Mahimainathan L, Choudhury GG.

J Biol Chem. 2004 Apr 9;279(15):15258-68. Epub 2004 Jan 12.PMID: 14718524 [PubMed - indexed for MEDLINE]Related articlesFree article

PTEN, more than the AKT pathway.

Blanco-Aparicio C, Renner O, Leal JF, Carnero A.

Carcinogenesis. 2007 Jul;28(7):1379-86. Epub 2007 Mar 6. Review.PMID: 17341655 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation.

Servidei T, Riccardi A, Sanguinetti M, Dominici C, Riccardi R.

J Cell Physiol. 2006 Jul;208(1):220-8.PMID: 16575905 [PubMed - indexed for MEDLINE]Related articles

PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis.

Fang J, Ding M, Yang L, Liu LZ, Jiang BH.

Cell Signal. 2007 Dec;19(12):2487-97. Epub 2007 Aug 15.PMID: 17826033 [PubMed - indexed for MEDLINE]Related articlesFree article

The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.

Cardone RA, Bellizzi A, Busco G, Weinman EJ, Dell'Aquila ME, Casavola V, Azzariti A, Mangia A, Paradiso A, Reshkin SJ.

Mol Biol Cell. 2007 May;18(5):1768-80. Epub 2007 Mar 1.PMID: 17332506 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.

Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, Dutcher J, Clouthier SG, Wicha MS.

PLoS Biol. 2009 Jun 2;7(6):e1000121. Epub 2009 Jun 2.PMID: 19492080 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity.

Lue H, Thiele M, Franz J, Dahl E, Speckgens S, Leng L, Fingerle-Rowson G, Bucala R, Lüscher B, Bernhagen J.

Oncogene. 2007 Aug 2;26(35):5046-59. Epub 2007 Feb 19.PMID: 17310986 [PubMed - indexed for MEDLINE]Related articles

PTEN-deficient cancers depend on PIK3CB.

Wee S, Wiederschain D, Maira SM, Loo A, Miller C, deBeaumont R, Stegmeier F, Yao YM, Lengauer C.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13057-62. Epub 2008 Aug 28.PMID: 18755892 [PubMed - indexed for MEDLINE]Related articlesFree article

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR.

Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, Griffin JD, Kwiatkowski DJ.

J Clin Invest. 2007 Mar;117(3):730-8. Epub 2007 Feb 8.PMID: 17290308 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of Na+/H+ exchange by platelet-derived growth factor involves phosphatidylinositol 3'-kinase and phospholipase C gamma.

Ma YH, Reusch HP, Wilson E, Escobedo JA, Fantl WJ, Williams LT, Ives HE.

J Biol Chem. 1994 Dec 2;269(48):30734-9.PMID: 7982995 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.

Fine B, Hodakoski C, Koujak S, Su T, Saal LH, Maurer M, Hopkins B, Keniry M, Sulis ML, Mense S, Hibshoosh H, Parsons R.

Science. 2009 Sep 4;325(5945):1261-5.PMID: 19729658 [PubMed - indexed for MEDLINE]Related articles

Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.

Maudsley S, Zamah AM, Rahman N, Blitzer JT, Luttrell LM, Lefkowitz RJ, Hall RA.

Mol Cell Biol. 2000 Nov;20(22):8352-63.PMID: 11046132 [PubMed - indexed for MEDLINE]Related articlesFree article