PubMed

Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer.

Wu Y, Mohamed H, Chillar R, Ali I, Clayton S, Slamon D, Vadgama JV.

Breast Cancer Res. 2008;10(1):R3. Epub 2008 Jan 10.PMID: 18184439 [PubMed - indexed for MEDLINE]Related articlesFree article

Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors.

Frogne T, Laenkholm AV, Lyng MB, Henriksen KL, Lykkesfeldt AE.

Breast Cancer Res. 2009;11(1):R11. Epub 2009 Feb 24.PMID: 19239686 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue microarray-based study of patients with lymph node-negative breast cancer shows that HER2/neu overexpression is an important predictive marker of poor prognosis.

Choi YH, Ahn JH, Kim SB, Jung KH, Gong GY, Kim MJ, Son BH, Ahn SH, Kim WK.

Ann Oncol. 2009 Aug;20(8):1337-43. Epub 2009 Feb 16.PMID: 19221151 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients.

Xia W, Chen JS, Zhou X, Sun PR, Lee DF, Liao Y, Zhou BP, Hung MC.

Clin Cancer Res. 2004 Jun 1;10(11):3815-24.PMID: 15173090 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor histology and stage but not p53, Her2-neu or cathepsin-D expression are independent prognostic factors in breast cancer patients.

Korkolis DP, Tsoli E, Fouskakis D, Yiotis J, Koullias GJ, Giannopoulos D, Papalambros E, Nikiteas NI, Spiliopoulou CA, Patsouris E, Asimacopoulos P, Gorgoulis VG.

Anticancer Res. 2004 May-Jun;24(3b):2061-8.PMID: 15274401 [PubMed - indexed for MEDLINE]Related articles

Prognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 cases.

Schmitz KJ, Otterbach F, Callies R, Levkau B, Hölscher M, Hoffmann O, Grabellus F, Kimmig R, Schmid KW, Baba HA.

Mod Pathol. 2004 Jan;17(1):15-21.PMID: 14631376 [PubMed - indexed for MEDLINE]Related articlesFree article

C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu.

Lengyel E, Prechtel D, Resau JH, Gauger K, Welk A, Lindemann K, Salanti G, Richter T, Knudsen B, Vande Woude GF, Harbeck N.

Int J Cancer. 2005 Feb 10;113(4):678-82.PMID: 15455388 [PubMed - indexed for MEDLINE]Related articles

EGFR, pMAPK, pAkt and PTEN status by immunohistochemistry: correlation with clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab.

Gori S, Sidoni A, Colozza M, Ferri I, Mameli MG, Fenocchio D, Stocchi L, Foglietta J, Ludovini V, Minenza E, De Angelis V, Crinò L.

Ann Oncol. 2009 Apr;20(4):648-54. Epub 2009 Feb 2.PMID: 19188134 [PubMed - indexed for MEDLINE]Related articles

Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients.

Tokunaga E, Kimura Y, Oki E, Ueda N, Futatsugi M, Mashino K, Yamamoto M, Ikebe M, Kakeji Y, Baba H, Maehara Y.

Int J Cancer. 2006 Jan 15;118(2):284-9.PMID: 16049961 [PubMed - indexed for MEDLINE]Related articles

Activated Akt signaling pathway in invasive ductal carcinoma of the breast: correlation with HER2 overexpression.

Park SS, Kim SW.

Oncol Rep. 2007 Jul;18(1):139-43.PMID: 17549359 [PubMed - indexed for MEDLINE]Related articles

The association between Akt activation and resistance to hormone therapy in metastatic breast cancer.

Tokunaga E, Kataoka A, Kimura Y, Oki E, Mashino K, Nishida K, Koga T, Morita M, Kakeji Y, Baba H, Ohno S, Maehara Y.

Eur J Cancer. 2006 Mar;42(5):629-35. Epub 2006 Feb 7.PMID: 16464571 [PubMed - indexed for MEDLINE]Related articles

Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: results from International Breast Cancer Study Group Trial V.

Spataro VJ, Litman H, Viale G, Maffini F, Masullo M, Golouh R, Martinez-Tello FJ, Grigolato P, Shilkin KB, Gusterson BA, Castiglione-Gertsch M, Price K, Lindtner J, Cortés-Funes H, Simoncini E, Byrne MJ, Collins J, Gelber RD, Coates AS, Goldhirsch A; International Breast Cancer Study Group.

Cancer. 2003 Apr 1;97(7):1591-600.PMID: 12655514 [PubMed - indexed for MEDLINE]Related articlesFree article

HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma.

Allred DC, Clark GM, Tandon AK, Molina R, Tormey DC, Osborne CK, Gilchrist KW, Mansour EG, Abeloff M, Eudey L, et al.

J Clin Oncol. 1992 Apr;10(4):599-605.PMID: 1548522 [PubMed - indexed for MEDLINE]Related articles

Metastatic breast cancer with HER2/neu-positive cells tends to have a morbid prognosis.

Emi Y, Kitamura K, Shikada Y, Kakeji Y, Takahashi I, Tsutsui S.

Surgery. 2002 Jan;131(1 Suppl):S217-21.PMID: 11821814 [PubMed - indexed for MEDLINE]Related articles

Clinical relevance of HER2 overexpression/amplification in patients with small tumor size and node-negative breast cancer.

Curigliano G, Viale G, Bagnardi V, Fumagalli L, Locatelli M, Rotmensz N, Ghisini R, Colleoni M, Munzone E, Veronesi P, Zurrida S, Nolè F, Goldhirsch A.

J Clin Oncol. 2009 Dec 1;27(34):5693-9. Epub 2009 Nov 2.PMID: 19884553 [PubMed - indexed for MEDLINE]Related articles

Expression patterns and predictive value of phosphorylated AKT in early-stage breast cancer.

Andre F, Nahta R, Conforti R, Boulet T, Aziz M, Yuan LX, Meslin F, Spielmann M, Tomasic G, Pusztai L, Hortobagyi GN, Michiels S, Delaloge S, Esteva FJ.

Ann Oncol. 2008 Feb;19(2):315-20. Epub 2007 Sep 5.PMID: 17804473 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of PI3K/Akt signaling and hormone resistance in breast cancer.

Tokunaga E, Kimura Y, Mashino K, Oki E, Kataoka A, Ohno S, Morita M, Kakeji Y, Baba H, Maehara Y.

Breast Cancer. 2006;13(2):137-44.PMID: 16755107 [PubMed - indexed for MEDLINE]Related articlesFree article

[The effect of HER2/neu overexpression on p53 gene expression, cell proliferation and sensitivity to gamma-irradiation via the PI3K/Akt pathway in breast cancer cell MCF7]

Zheng L, Ren JQ, Chen Q, Zhang HP, Zhu HG.

Zhonghua Zhong Liu Za Zhi. 2004 Oct;26(10):594-7. Chinese. PMID: 15634518 [PubMed - indexed for MEDLINE]Related articles

Immunohistochemical expression of PTEN and phosphorylated Akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy.

Yonemori K, Tsuta K, Shimizu C, Hatanaka Y, Hashizume K, Ono M, Kouno T, Ando M, Tamura K, Katsumata N, Hasegawa T, Kinoshita T, Fujiwara Y.

Med Oncol. 2009;26(3):344-9. Epub 2008 Nov 18.PMID: 19016009 [PubMed - indexed for MEDLINE]Related articles

AKT activation predicts outcome in breast cancer patients treated with tamoxifen.

Kirkegaard T, Witton CJ, McGlynn LM, Tovey SM, Dunne B, Lyon A, Bartlett JM.

J Pathol. 2005 Oct;207(2):139-46.PMID: 16088978 [PubMed - indexed for MEDLINE]Related articles