PubMed

The ubiquitin E3 ligase activity of BRCA1 and its biological functions.

Wu W, Koike A, Takeshita T, Ohta T.

Cell Div. 2008 Jan 7;3:1.PMID: 18179693 [PubMed - in process]Related articlesFree article

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.

Reid LJ, Shakya R, Modi AP, Lokshin M, Cheng JT, Jasin M, Baer R, Ludwig T.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20876-81. Epub 2008 Dec 16.PMID: 19088202 [PubMed - indexed for MEDLINE]Related articlesFree article

RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites.

Yan J, Jetten AM.

Cancer Lett. 2008 Nov 28;271(2):179-90. Epub 2008 Jun 11. Review.PMID: 18550271 [PubMed - indexed for MEDLINE]Related articlesFree article

Contemplating chemosensitivity of basal-like breast cancer based on BRCA1 dysfunction.

Ohta T, Wu W, Koike A, Asakawa H, Koizumi H, Fukuda M.

Breast Cancer. 2009;16(4):268-74. Epub 2009 May 21.PMID: 19459031 [PubMed - indexed for MEDLINE]Related articles

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function.

Nikkilä J, Coleman KA, Morrissey D, Pylkäs K, Erkko H, Messick TE, Karppinen SM, Amelina A, Winqvist R, Greenberg RA.

Oncogene. 2009 Apr 23;28(16):1843-52. Epub 2009 Mar 23.PMID: 19305427 [PubMed - indexed for MEDLINE]Related articlesFree article

The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.

Yan J, Kim YS, Yang XP, Li LP, Liao G, Xia F, Jetten AM.

Cancer Res. 2007 Jul 15;67(14):6647-56. Epub 2007 Jul 9.PMID: 17621610 [PubMed - indexed for MEDLINE]Related articlesFree article

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation.

Hashizume R, Fukuda M, Maeda I, Nishikawa H, Oyake D, Yabuki Y, Ogata H, Ohta T.

J Biol Chem. 2001 May 4;276(18):14537-40. Epub 2001 Mar 6.PMID: 11278247 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein.

Xia Y, Pao GM, Chen HW, Verma IM, Hunter T.

J Biol Chem. 2003 Feb 14;278(7):5255-63. Epub 2002 Nov 12.PMID: 12431996 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function.

Sankaran S, Starita LM, Simons AM, Parvin JD.

Cancer Res. 2006 Apr 15;66(8):4100-7.PMID: 16618730 [PubMed - indexed for MEDLINE]Related articlesFree article

BRCA1/BARD1 E3 ubiquitin ligase can modify histones H2A and H2B in the nucleosome particle.

Thakar A, Parvin JD, Zlatanova J.

J Biomol Struct Dyn. 2010 Feb;27(4):399-406.PMID: 19916563 [PubMed - indexed for MEDLINE]Related articles

Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.

Christensen DE, Klevit RE.

FEBS J. 2009 Oct;276(19):5381-9. Epub 2009 Aug 27. Review.PMID: 19712108 [PubMed - indexed for MEDLINE]Related articles

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.

Wang B, Elledge SJ.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20759-63. Epub 2007 Dec 5.PMID: 18077395 [PubMed - indexed for MEDLINE]Related articlesFree article

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity.

Baer R, Ludwig T.

Curr Opin Genet Dev. 2002 Feb;12(1):86-91. Review.PMID: 11790560 [PubMed - indexed for MEDLINE]Related articles

BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity.

Nishikawa H, Wu W, Koike A, Kojima R, Gomi H, Fukuda M, Ohta T.

Cancer Res. 2009 Jan 1;69(1):111-9.PMID: 19117993 [PubMed - indexed for MEDLINE]Related articlesFree article

BRCA1 DNA-binding activity is stimulated by BARD1.

Simons AM, Horwitz AA, Starita LM, Griffin K, Williams RS, Glover JN, Parvin JD.

Cancer Res. 2006 Feb 15;66(4):2012-8.PMID: 16489000 [PubMed - indexed for MEDLINE]Related articlesFree article

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.

Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA.

Science. 2007 May 25;316(5828):1198-202.PMID: 17525341 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic exploitation of tumor cell defects in homologous recombination.

Powell SN, Kachnic LA.

Anticancer Agents Med Chem. 2008 May;8(4):448-60. Review.PMID: 18473729 [PubMed - indexed for MEDLINE]Related articles

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.

Shao G, Patterson-Fortin J, Messick TE, Feng D, Shanbhag N, Wang Y, Greenberg RA.

Genes Dev. 2009 Mar 15;23(6):740-54. Epub 2009 Mar 4.PMID: 19261746 [PubMed - indexed for MEDLINE]Related articlesFree article

BRCA1 control of steroid receptor ubiquitination.

Heine GF, Parvin JD.

Sci STKE. 2007 Jun 19;2007(391):pe34.PMID: 17579243 [PubMed - indexed for MEDLINE]Related articles

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.

Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5. Epub 2008 Apr 28.PMID: 18443292 [PubMed - indexed for MEDLINE]Related articlesFree article