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    Results: 1 to 20 of 196

    1.

    Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.

    Martinez SC, Tanabe K, Cras-Méneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA.

    Diabetes. 2008 Apr;57(4):846-59. Epub 2008 Jan 3.PMID: 18174526 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

    Akerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR.

    Diabetes. 2008 Nov;57(11):3034-44. Epub 2008 Jun 30.PMID: 18591394 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

    Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G.

    PLoS One. 2009;4(3):e4954. Epub 2009 Mar 23.PMID: 19305497 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

    Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

    J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. Epub 2008 Jun 17.PMID: 18559892 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells.

    Srinivasan S, Ohsugi M, Liu Z, Fatrai S, Bernal-Mizrachi E, Permutt MA.

    Diabetes. 2005 Apr;54(4):968-75.PMID: 15793234 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis.

    Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A.

    Endocrinology. 2006 Jul;147(7):3398-407. Epub 2006 Apr 6.PMID: 16601139 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.

    Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A.

    Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E540-50. Epub 2008 Jan 15.PMID: 18198352 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes.

    Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ.

    Diabetologia. 2007 Apr;50(4):752-63. Epub 2007 Feb 1.PMID: 17268797 [PubMed - indexed for MEDLINE]Related articles

    9.

    Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes.

    Guo W, Wong S, Xie W, Lei T, Luo Z.

    Am J Physiol Endocrinol Metab. 2007 Aug;293(2):E576-86. Epub 2007 May 22.PMID: 17519282 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

    Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

    Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.PMID: 15297438 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression.

    Kim SJ, Winter K, Nian C, Tsuneoka M, Koda Y, McIntosh CH.

    J Biol Chem. 2005 Jun 10;280(23):22297-307. Epub 2005 Apr 6.PMID: 15817464 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.

    Pirot P, Ortis F, Cnop M, Ma Y, Hendershot LM, Eizirik DL, Cardozo AK.

    Diabetes. 2007 Apr;56(4):1069-77.PMID: 17395747 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell.

    Martinez SC, Cras-Méneur C, Bernal-Mizrachi E, Permutt MA.

    Diabetes. 2006 Jun;55(6):1581-91.PMID: 16731820 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    IL-1beta caused pancreatic beta-cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca2+ release through the c-Jun N-terminal kinase pathway.

    Wang Q, Zhang H, Zhao B, Fei H.

    Mol Cell Biochem. 2009 Apr;324(1-2):183-90. Epub 2008 Dec 25.PMID: 19109696 [PubMed - indexed for MEDLINE]Related articles

    15.

    Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms.

    Pirot P, Eizirik DL, Cardozo AK.

    Diabetologia. 2006 Jun;49(6):1229-36. Epub 2006 Apr 8.PMID: 16604358 [PubMed - indexed for MEDLINE]Related articles

    16.

    Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

    Luciani DS, Gwiazda KS, Yang TL, Kalynyak TB, Bychkivska Y, Frey MH, Jeffrey KD, Sampaio AV, Underhill TM, Johnson JD.

    Diabetes. 2009 Feb;58(2):422-32. Epub 2008 Nov 25.PMID: 19033399 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress.

    Senokuchi T, Liang CP, Seimon TA, Han S, Matsumoto M, Banks AS, Paik JH, DePinho RA, Accili D, Tabas I, Tall AR.

    Diabetes. 2008 Nov;57(11):2967-76. Epub 2008 Aug 26.PMID: 18728232 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

    Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL.

    J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.PMID: 17158450 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.

    Tonnesen MF, Grunnet LG, Friberg J, Cardozo AK, Billestrup N, Eizirik DL, Størling J, Mandrup-Poulsen T.

    Endocrinology. 2009 Sep;150(9):4094-103. Epub 2009 Jun 25.PMID: 19556421 [PubMed - indexed for MEDLINE]Related articles

    20.

    Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids.

    Diakogiannaki E, Welters HJ, Morgan NG.

    J Endocrinol. 2008 Jun;197(3):553-63.PMID: 18492819 [PubMed - indexed for MEDLINE]Related articlesFree article

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