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    Results: 1 to 20 of 466

    1.

    mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes.

    Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, Berthault MF, Magnan C, Cerasi E, Kaiser N, Leibowitz G.

    Diabetes. 2008 Apr;57(4):945-57. Epub 2008 Jan 3.PMID: 18174523 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.

    Nesher R, Warwar N, Khan A, Efendic S, Cerasi E, Kaiser N.

    Diabetes. 2001 Feb;50(2):308-14.PMID: 11272141 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

    Khamzina L, Veilleux A, Bergeron S, Marette A.

    Endocrinology. 2005 Mar;146(3):1473-81. Epub 2004 Dec 16.PMID: 15604215 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Acetaldehyde promotes rapamycin-dependent activation of p70(S6K) and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells.

    Fang CX, Yang X, Sreejayan N, Ren J.

    Exp Neurol. 2007 Jan;203(1):196-204. Epub 2006 Sep 7.PMID: 16962100 [PubMed - indexed for MEDLINE]Related articles

    5.

    A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle.

    Glynn EL, Lujan HL, Kramer VJ, Drummond MJ, DiCarlo SE, Rasmussen BB.

    Appl Physiol Nutr Metab. 2008 Feb;33(1):93-101.PMID: 18347658 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway.

    Kim JH, Kim JE, Liu HY, Cao W, Chen J.

    J Biol Chem. 2008 Jan 11;283(2):708-15. Epub 2007 Nov 10.PMID: 17993646 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Nutritionally induced diabetes in desert rodents as models of type 2 diabetes: Acomys cahirinus (spiny mice) and Psammomys obesus (desert gerbil).

    Shafrir E, Ziv E, Kalman R.

    ILAR J. 2006;47(3):212-24. Review.PMID: 16804196 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets.

    Shaked M, Ketzinel-Gilad M, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

    Diabetologia. 2009 Apr;52(4):636-44. Epub 2009 Feb 13.PMID: 19214472 [PubMed - indexed for MEDLINE]Related articles

    9.

    Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

    Donath MY, Gross DJ, Cerasi E, Kaiser N.

    Diabetes. 1999 Apr;48(4):738-44.PMID: 10102689 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Interaction between genetic and dietary factors determines beta-cell function in Psammomys obesus, an animal model of type 2 diabetes.

    Nesher R, Gross DJ, Donath MY, Cerasi E, Kaiser N.

    Diabetes. 1999 Apr;48(4):731-7.PMID: 10102688 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.

    Briaud I, Dickson LM, Lingohr MK, McCuaig JF, Lawrence JC, Rhodes CJ.

    J Biol Chem. 2005 Jan 21;280(3):2282-93. Epub 2004 Nov 9.PMID: 15537654 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes.

    Leibowitz G, Yuli M, Donath MY, Nesher R, Melloul D, Cerasi E, Gross DJ, Kaiser N.

    Diabetes. 2001 Feb;50 Suppl 1:S113-7.PMID: 11272167 [PubMed - indexed for MEDLINE]Related articles

    13.

    Effects of rapamycin on cell proliferation and phosphorylation of mTOR and p70(S6K) in HepG2 and HepG2 cells overexpressing constitutively active Akt/PKB.

    Varma S, Khandelwal RL.

    Biochim Biophys Acta. 2007 Jan;1770(1):71-8. Epub 2006 Aug 1.PMID: 16952420 [PubMed - indexed for MEDLINE]Related articles

    14.

    Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus.

    Mack E, Ziv E, Reuveni H, Kalman R, Niv MY, Jörns A, Lenzen S, Shafrir E.

    Diabetes Metab Res Rev. 2008 Oct;24(7):577-84.PMID: 18613220 [PubMed - indexed for MEDLINE]Related articles

    15.

    Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation.

    Alliouachene S, Tuttle RL, Boumard S, Lapointe T, Berissi S, Germain S, Jaubert F, Tosh D, Birnbaum MJ, Pende M.

    J Clin Invest. 2008 Nov;118(11):3629-38. Epub 2008 Oct 9.PMID: 18846252 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets.

    Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, Marshall CA, McDaniel ML.

    Diabetes. 2009 Mar;58(3):663-72. Epub 2008 Dec 10.PMID: 19073772 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes.

    Leibowitz G, Cerasi E, Ketzinel-Gilad M.

    Diabetes Obes Metab. 2008 Nov;10 Suppl 4:157-69. Review.PMID: 18834443 [PubMed - indexed for MEDLINE]Related articles

    18.

    Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control.

    Kaiser N, Yuli M, Uçkaya G, Oprescu AI, Berthault MF, Kargar C, Donath MY, Cerasi E, Ktorza A.

    Diabetes. 2005 Jan;54(1):138-45.PMID: 15616021 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Rapamycin attenuates load-induced cardiac hypertrophy in mice.

    Shioi T, McMullen JR, Tarnavski O, Converso K, Sherwood MC, Manning WJ, Izumo S.

    Circulation. 2003 Apr 1;107(12):1664-70. Epub 2003 Mar 17.PMID: 12668503 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets.

    Kwon G, Marshall CA, Pappan KL, Remedi MS, McDaniel ML.

    Diabetes. 2004 Dec;53 Suppl 3:S225-32. Review.PMID: 15561916 [PubMed - indexed for MEDLINE]Related articlesFree article

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