PubMed

Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene.

Cherednichenko G, Ward CW, Feng W, Cabrales E, Michaelson L, Samso M, López JR, Allen PD, Pessah IN.

Mol Pharmacol. 2008 Apr;73(4):1203-12. Epub 2008 Jan 2.PMID: 18171728 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated resting [Ca(2+)](i) in myotubes expressing malignant hyperthermia RyR1 cDNAs is partially restored by modulation of passive calcium leak from the SR.

Yang T, Esteve E, Pessah IN, Molinski TF, Allen PD, López JR.

Am J Physiol Cell Physiol. 2007 May;292(5):C1591-8. Epub 2006 Dec 20.PMID: 17182726 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant hyperthermia mutations.

Yang T, Allen PD, Pessah IN, Lopez JR.

J Biol Chem. 2007 Dec 28;282(52):37471-8. Epub 2007 Oct 16.PMID: 17942409 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse.

Yang T, Riehl J, Esteve E, Matthaei KI, Goth S, Allen PD, Pessah IN, Lopez JR.

Anesthesiology. 2006 Dec;105(6):1164-75.PMID: 17122579 [PubMed - indexed for MEDLINE]Related articlesFree article

Dantrolene sodium can increase or attenuate activity of skeletal muscle ryanodine receptor calcium release channel. Clinical implications.

Nelson TE, Lin M, Zapata-Sudo G, Sudo RT.

Anesthesiology. 1996 Jun;84(6):1368-79.PMID: 8669678 [PubMed - indexed for MEDLINE]Related articlesFree article

Dantrolene inhibition of sarcoplasmic reticulum Ca2+ release by direct and specific action at skeletal muscle ryanodine receptors.

Fruen BR, Mickelson JR, Louis CF.

J Biol Chem. 1997 Oct 24;272(43):26965-71.PMID: 9341133 [PubMed - indexed for MEDLINE]Related articlesFree article

The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entry.

Bannister RA, Pessah IN, Beam KG.

J Gen Physiol. 2009 Jan;133(1):79-91.PMID: 19114636 [PubMed - indexed for MEDLINE]Related articlesFree article

Halothane modulation of skeletal muscle ryanodine receptors: dependence on Ca2+, Mg2+, and ATP.

Diaz-Sylvester PL, Porta M, Copello JA.

Am J Physiol Cell Physiol. 2008 Apr;294(4):C1103-12. Epub 2008 Feb 27.PMID: 18305228 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional defects in six ryanodine receptor isoform-1 (RyR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation-contraction coupling.

Yang T, Ta TA, Pessah IN, Allen PD.

J Biol Chem. 2003 Jul 11;278(28):25722-30. Epub 2003 May 5.PMID: 12732639 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased sensitivity to 4-chloro-m-cresol and caffeine in primary myotubes from malignant hyperthermia susceptible individuals carrying the ryanodine receptor 1 Thr2206Met (C6617T) mutation.

Wehner M, Rueffert H, Koenig F, Neuhaus J, Olthoff D.

Clin Genet. 2002 Aug;62(2):135-46.PMID: 12220451 [PubMed - indexed for MEDLINE]Related articles

Malignant hyperthermia: an inherited disorder of skeletal muscle Ca+ regulation.

Louis CF, Balog EM, Fruen BR.

Biosci Rep. 2001 Apr;21(2):155-68. Review.PMID: 11725864 [PubMed - indexed for MEDLINE]Related articles

Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95).

Ta TA, Pessah IN.

Neurotoxicology. 2007 Jul;28(4):770-9. Epub 2006 Aug 30.PMID: 17023049 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling.

Weiss RG, O'Connell KM, Flucher BE, Allen PD, Grabner M, Dirksen RT.

Am J Physiol Cell Physiol. 2004 Oct;287(4):C1094-102. Epub 2004 Jun 16.PMID: 15201141 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala.

Wehner M, Rueffert H, Koenig F, Olthoff D.

Genet Test. 2003 Fall;7(3):203-11.PMID: 14641996 [PubMed - indexed for MEDLINE]Related articles

Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia.

Jiang D, Chen W, Xiao J, Wang R, Kong H, Jones PP, Zhang L, Fruen B, Chen SR.

J Biol Chem. 2008 Jul 25;283(30):20813-20. Epub 2008 May 27.PMID: 18505726 [PubMed - indexed for MEDLINE]Related articlesFree article

Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletion.

Hurne AM, O'Brien JJ, Wingrove D, Cherednichenko G, Allen PD, Beam KG, Pessah IN.

J Biol Chem. 2005 Nov 4;280(44):36994-7004. Epub 2005 Aug 24.PMID: 16120606 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct effects on Ca2+ handling caused by malignant hyperthermia and central core disease mutations in RyR1.

Dirksen RT, Avila G.

Biophys J. 2004 Nov;87(5):3193-204. Epub 2004 Sep 3.PMID: 15347586 [PubMed - indexed for MEDLINE]Related articlesFree article

The point mutation Arg615-->Cys in the Ca2+ release channel of skeletal sarcoplasmic reticulum is responsible for hypersensitivity to caffeine and halothane in malignant hyperthermia.

Otsu K, Nishida K, Kimura Y, Kuzuya T, Hori M, Kamada T, Tada M.

J Biol Chem. 1994 Apr 1;269(13):9413-5.PMID: 7511586 [PubMed - indexed for MEDLINE]Related articlesFree article

Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor.

Zhao X, Weisleder N, Han X, Pan Z, Parness J, Brotto M, Ma J.

J Biol Chem. 2006 Nov 3;281(44):33477-86. Epub 2006 Aug 31.PMID: 16945924 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel ryanodine receptor mutation that may cause malignant hyperthermia.

Kaufmann A, Kraft B, Michalek-Sauberer A, Weigl LG.

Anesthesiology. 2008 Sep;109(3):457-64.PMID: 18719443 [PubMed - indexed for MEDLINE]Related articlesFree article