PubMed

Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis.

Chen J, Saxena G, Mungrue IN, Lusis AJ, Shalev A.

Diabetes. 2008 Apr;57(4):938-44. Epub 2008 Jan 2.PMID: 18171713 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of TXNIP protects beta-cells against glucotoxicity.

Shalev A.

Biochem Soc Trans. 2008 Oct;36(Pt 5):963-5.PMID: 18793170 [PubMed - indexed for MEDLINE]Related articles

Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets.

Shaked M, Ketzinel-Gilad M, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

Diabetologia. 2009 Apr;52(4):636-44. Epub 2009 Feb 13.PMID: 19214472 [PubMed - indexed for MEDLINE]Related articles

Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis.

Minn AH, Hafele C, Shalev A.

Endocrinology. 2005 May;146(5):2397-405. Epub 2005 Feb 10.PMID: 15705778 [PubMed - indexed for MEDLINE]Related articlesFree article

High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.

Masson E, Koren S, Razik F, Goldberg H, Kwan EP, Sheu L, Gaisano HY, Fantus IG.

Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1251-61. Epub 2009 Feb 17.PMID: 19223654 [PubMed - indexed for MEDLINE]Related articles

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.

Chen J, Hui ST, Couto FM, Mungrue IN, Davis DB, Attie AD, Lusis AJ, Davis RA, Shalev A.

FASEB J. 2008 Oct;22(10):3581-94. Epub 2008 Jun 13.PMID: 18552236 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein.

Chen J, Cha-Molstad H, Szabo A, Shalev A.

Am J Physiol Endocrinol Metab. 2009 May;296(5):E1133-9. Epub 2009 Mar 3.PMID: 19258488 [PubMed - indexed for MEDLINE]Related articles

Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein.

Chen J, Couto FM, Minn AH, Shalev A.

Biochem Biophys Res Commun. 2006 Aug 4;346(3):1067-74. Epub 2006 Jun 13.PMID: 16782054 [PubMed - indexed for MEDLINE]Related articles

Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.

Costes S, Vandewalle B, Tourrel-Cuzin C, Broca C, Linck N, Bertrand G, Kerr-Conte J, Portha B, Pattou F, Bockaert J, Dalle S.

Diabetes. 2009 May;58(5):1105-15. Epub 2009 Feb 17.PMID: 19223597 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells.

Cha-Molstad H, Saxena G, Chen J, Shalev A.

J Biol Chem. 2009 Jun 19;284(25):16898-905. Epub 2009 May 1.PMID: 19411249 [PubMed - indexed for MEDLINE]Related articles

Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

McKenzie MD, Carrington EM, Kaufmann T, Strasser A, Huang DC, Kay TW, Allison J, Thomas HE.

Diabetes. 2008 May;57(5):1284-92. Epub 2008 Feb 5.PMID: 18252892 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals.

Hui TY, Sheth SS, Diffley JM, Potter DW, Lusis AJ, Attie AD, Davis RA.

J Biol Chem. 2004 Jun 4;279(23):24387-93. Epub 2004 Mar 26.PMID: 15047687 [PubMed - indexed for MEDLINE]Related articlesFree article

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

Metabolism. 2002 Oct;51(10):1340-7.PMID: 12370856 [PubMed - indexed for MEDLINE]Related articles

Lack of TXNIP protects against mitochondria-mediated apoptosis, but not against fatty acid-induced, ER-stress-mediated beta cell death.

Chen J, Fontes G, Saxena G, Poitout V, Shalev A.

Diabetes. 2009 Oct 29. [Epub ahead of print]PMID: 19875615 [PubMed - as supplied by publisher]Related articles

Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production.

Chutkow WA, Patwari P, Yoshioka J, Lee RT.

J Biol Chem. 2008 Jan 25;283(4):2397-406. Epub 2007 Nov 12.PMID: 17998203 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets.

Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K.

Diabetes. 2008 Mar;57(3):645-53. Epub 2007 Dec 10.PMID: 18071026 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolism-independent sugar effects on gene transcription: the role of 3-O-methylglucose.

Minn AH, Couto FM, Shalev A.

Biochemistry. 2006 Sep 19;45(37):11047-51.PMID: 16964965 [PubMed - indexed for MEDLINE]Related articles

Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.

Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.

Endocrinology. 2002 Apr;143(4):1530-7.PMID: 11897712 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line.

Oetjen E, Lechleiter A, Blume R, Nihalani D, Holzman L, Knepel W.

Diabetologia. 2006 Feb;49(2):332-42. Epub 2005 Dec 21.PMID: 16369771 [PubMed - indexed for MEDLINE]Related articles