PubMed

Multiple paxillin binding sites regulate FAK function.

Scheswohl DM, Harrell JR, Rajfur Z, Gao G, Campbell SL, Schaller MD.

J Mol Signal. 2008 Jan 2;3:1.PMID: 18171471 [PubMed - in process]Related articlesFree article

NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model.

Gao G, Prutzman KC, King ML, Scheswohl DM, DeRose EF, London RE, Schaller MD, Campbell SL.

J Biol Chem. 2004 Feb 27;279(9):8441-51. Epub 2003 Dec 7.PMID: 14662767 [PubMed - indexed for MEDLINE]Related articlesFree article

GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin.

Schmalzigaug R, Garron ML, Roseman JT, Xing Y, Davidson CE, Arold ST, Premont RT.

Cell Signal. 2007 Aug;19(8):1733-44. Epub 2007 Mar 30.PMID: 17467235 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural features of the focal adhesion kinase-paxillin complex give insight into the dynamics of focal adhesion assembly.

Bertolucci CM, Guibao CD, Zheng J.

Protein Sci. 2005 Mar;14(3):644-52. Epub 2005 Feb 2.PMID: 15689512 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of formation of an ERK-FAK-paxillin complex in migration of human corneal epithelial cells during wound closure in vitro.

Teranishi S, Kimura K, Nishida T.

Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5646-52. Epub 2009 Jun 3.PMID: 19494198 [PubMed - indexed for MEDLINE]Related articles

Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2.

Lulo J, Yuzawa S, Schlessinger J.

Biochem Biophys Res Commun. 2009 Jun 5;383(3):347-52. Epub 2009 Apr 7.PMID: 19358827 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase.

Bertolucci CM, Guibao CD, Zheng JJ.

Biochemistry. 2008 Jan 15;47(2):548-54. Epub 2007 Dec 20.PMID: 18092823 [PubMed - indexed for MEDLINE]Related articles

Force-induced unfolding of the focal adhesion targeting domain and the influence of paxillin binding.

Mofrad MR, Golji J, Abdul Rahim NA, Kamm RD.

Mech Chem Biosyst. 2004 Dec;1(4):253-65.PMID: 16783922 [PubMed - indexed for MEDLINE]Related articles

Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis.

Chu PY, Huang LY, Hsu CH, Liang CC, Guan JL, Hung TH, Shen TL.

J Biol Chem. 2009 Jul 24;284(30):20215-26. Epub 2009 May 27.PMID: 19473962 [PubMed - indexed for MEDLINE]Related articles

Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin.

Shan Y, Yu L, Li Y, Pan Y, Zhang Q, Wang F, Chen J, Zhu X.

PLoS Biol. 2009 May 12;7(5):e1000116. Epub 2009 May 26.PMID: 19492042 [PubMed - indexed for MEDLINE]Related articlesFree article

FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9.

Das A, Yaqoob U, Mehta D, Shah VH.

Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):562-70. Epub 2009 Jan 15.PMID: 19150878 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.

Kiely PA, Baillie GS, Barrett R, Buckley DA, Adams DR, Houslay MD, O'Connor R.

J Biol Chem. 2009 Jul 24;284(30):20263-74. Epub 2009 May 7.PMID: 19423701 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation of p130Cas initiates Rac activation and membrane ruffling.

Sharma A, Mayer BJ.

BMC Cell Biol. 2008 Sep 15;9:50.PMID: 18793427 [PubMed - indexed for MEDLINE]Related articlesFree article

New insights into FAK signaling and localization based on detection of a FAT domain folding intermediate.

Dixon RD, Chen Y, Ding F, Khare SD, Prutzman KC, Schaller MD, Campbell SL, Dokholyan NV.

Structure. 2004 Dec;12(12):2161-71.PMID: 15576030 [PubMed - indexed for MEDLINE]Related articles

GIT1 paxillin-binding domain is a four-helix bundle, and it binds to both paxillin LD2 and LD4 motifs.

Zhang ZM, Simmerman JA, Guibao CD, Zheng JJ.

J Biol Chem. 2008 Jul 4;283(27):18685-93. Epub 2008 Apr 30.PMID: 18448431 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain.

Hoellerer MK, Noble ME, Labesse G, Campbell ID, Werner JM, Arold ST.

Structure. 2003 Oct;11(10):1207-17.PMID: 14527389 [PubMed - indexed for MEDLINE]Related articles

Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.

Sachdev S, Bu Y, Gelman IH.

BMC Cancer. 2009 Jan 12;9:12.PMID: 19138410 [PubMed - indexed for MEDLINE]Related articlesFree article

Signal transduction by focal adhesion kinase in cancer.

Zhao J, Guan JL.

Cancer Metastasis Rev. 2009 Jun;28(1-2):35-49. Review.PMID: 19169797 [PubMed - indexed for MEDLINE]Related articles

The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning.

Golubovskaya VM, Finch R, Zheng M, Kurenova EV, Cance WG.

Biochem J. 2008 Apr 1;411(1):151-60.PMID: 18215142 [PubMed - indexed for MEDLINE]Related articlesFree article

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.

Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, Chen XL, Uryu SA, Canete-Soler R, Zhai J, Lin H, Schlaepfer WW, Nalbant P, Bokoch G, Ilic D, Waterman-Storer C, Schlaepfer DD.

J Cell Biol. 2008 Jan 14;180(1):187-203.PMID: 18195107 [PubMed - indexed for MEDLINE]Related articlesFree article