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Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro.

Jeffrey JE, Aspden RM.

Arthritis Res Ther. 2007;9(6):R129.PMID: 18096078 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study.

Mastbergen SC, Jansen NW, Bijlsma JW, Lafeber FP.

Arthritis Res Ther. 2006;8(1):R2.PMID: 16356188 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of caspase-9 reduces chondrocyte apoptosis and proteoglycan loss following mechanical trauma.

Huser CA, Peacock M, Davies ME.

Osteoarthritis Cartilage. 2006 Oct;14(10):1002-10. Epub 2006 May 12.PMID: 16698290 [PubMed - indexed for MEDLINE]Related articles

Effects of R and S enantiomers and a racemic mixture of carprofen on the production and release of proteoglycan and prostaglandin E2 from equine chondrocytes and cartilage explants.

Armstrong S, Lees P.

Am J Vet Res. 1999 Jan;60(1):98-104.PMID: 9918155 [PubMed - indexed for MEDLINE]Related articles

Selective COX-2 inhibition is favorable to human early and late-stage osteoarthritic cartilage: a human in vitro study.

Mastbergen SC, Bijlsma JW, Lafeber FP.

Osteoarthritis Cartilage. 2005 Jun;13(6):519-26.PMID: 15922186 [PubMed - indexed for MEDLINE]Related articles

Validation of an in vitro single-impact load model of the initiation of osteoarthritis-like changes in articular cartilage.

Huser CA, Davies ME.

J Orthop Res. 2006 Apr;24(4):725-32.PMID: 16514652 [PubMed - indexed for MEDLINE]Related articles

Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes.

Blanco FJ, Guitian R, Moreno J, de Toro FJ, Galdo F.

J Rheumatol. 1999 Jun;26(6):1366-73.PMID: 10381057 [PubMed - indexed for MEDLINE]Related articles

Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro.

Mbvundula EC, Bunning RA, Rainsford KD.

J Pharm Pharmacol. 2006 Mar;58(3):351-8.PMID: 16536902 [PubMed - indexed for MEDLINE]Related articles

Synthesis and release of human cartilage matrix proteoglycans are differently regulated by nitric oxide and prostaglandin-E2.

Mastbergen SC, Bijlsma JW, Lafeber FP.

Ann Rheum Dis. 2008 Jan;67(1):52-8. Epub 2007 May 7.PMID: 17485421 [PubMed - indexed for MEDLINE]Related articles

The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment.

de Boer TN, Huisman AM, Polak AA, Niehoff AG, van Rinsum AC, Saris D, Bijlsma JW, Lafeber FJ, Mastbergen SC.

Osteoarthritis Cartilage. 2009 Apr;17(4):482-8. Epub 2008 Oct 15.PMID: 18926729 [PubMed - indexed for MEDLINE]Related articles

Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis.

Alvarez-Soria MA, Herrero-Beaumont G, Moreno-Rubio J, Calvo E, Santillana J, Egido J, Largo R.

Osteoarthritis Cartilage. 2008 Dec;16(12):1484-93. Epub 2008 Jun 10.PMID: 18547825 [PubMed - indexed for MEDLINE]Related articles

Direct evidence for a role of cyclooxygenase 2-derived prostaglandin E2 in human head and neck xenograft tumors.

Zweifel BS, Davis TW, Ornberg RL, Masferrer JL.

Cancer Res. 2002 Nov 15;62(22):6706-11.PMID: 12438270 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of nimesulide and sodium diclofenac on interleukin-6, interleukin-8, proteoglycans and prostaglandin E2 production by human articular chondrocytes in vitro.

Henrotin YE, Labasse AH, Simonis PE, Zheng SX, Deby GP, Famaey JP, Crielaard JM, Reginster JY.

Clin Exp Rheumatol. 1999 Mar-Apr;17(2):151-60.PMID: 10342040 [PubMed - indexed for MEDLINE]Related articles

Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy.

Tchetina EV, Di Battista JA, Zukor DJ, Antoniou J, Poole AR.

Arthritis Res Ther. 2007;9(4):R75.PMID: 17683641 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants.

Hardy MM, Seibert K, Manning PT, Currie MG, Woerner BM, Edwards D, Koki A, Tripp CS.

Arthritis Rheum. 2002 Jul;46(7):1789-803.PMID: 12124863 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of equine recombinant interleukin-1alpha and interleukin-1beta on proteoglycan metabolism and prostaglandin E2 synthesis in equine articular cartilage explants.

Takafuji VA, McIlwraith CW, Howard RD.

Am J Vet Res. 2002 Apr;63(4):551-8.PMID: 11939318 [PubMed - indexed for MEDLINE]Related articles

Effects of meloxicam, compared with other NSAIDs, on cartilage proteoglycan metabolism, synovial prostaglandin E2, and production of interleukins 1, 6 and 8, in human and porcine explants in organ culture.

Rainsford KD, Ying C, Smith FC.

J Pharm Pharmacol. 1997 Oct;49(10):991-8.PMID: 9364409 [PubMed - indexed for MEDLINE]Related articles

Comparison of the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on proteoglycan synthesis by articular cartilage explant and chondrocyte monolayer cultures.

Collier S, Ghosh P.

Biochem Pharmacol. 1991 May 1;41(9):1375-84.PMID: 2018569 [PubMed - indexed for MEDLINE]Related articles

Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor.

Attur M, Al-Mussawir HE, Patel J, Kitay A, Dave M, Palmer G, Pillinger MH, Abramson SB.

J Immunol. 2008 Oct 1;181(7):5082-8. Erratum in: J Immunol. 2009 Jul 15;183(2):1496. PMID: 18802112 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential anti-inflammatory and chondroprotective effects of simulated digests of indomethacin and an herbal composite (Mobility) in a cartilage explant model of articular inflammation.

Pearson W, Orth MW, Lindinger MI.

J Vet Pharmacol Ther. 2007 Dec;30(6):523-33.PMID: 17991220 [PubMed - indexed for MEDLINE]Related articles