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    Results: 1 to 20 of 515

    1.

    Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control.

    Kolavennu V, Zeng L, Peng H, Wang Y, Danesh FR.

    Diabetes. 2008 Mar;57(3):714-23. Epub 2007 Dec 14.PMID: 18083785 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease.

    Peng F, Wu D, Gao B, Ingram AJ, Zhang B, Chorneyko K, McKenzie R, Krepinsky JC.

    Diabetes. 2008 Jun;57(6):1683-92. Epub 2008 Mar 20.PMID: 18356410 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats.

    Gojo A, Utsunomiya K, Taniguchi K, Yokota T, Ishizawa S, Kanazawa Y, Kurata H, Tajima N.

    Eur J Pharmacol. 2007 Jul 30;568(1-3):242-7. Epub 2007 Apr 20.PMID: 17511984 [PubMed - indexed for MEDLINE]Related articles

    4.

    Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.

    Arita R, Hata Y, Nakao S, Kita T, Miura M, Kawahara S, Zandi S, Almulki L, Tayyari F, Shimokawa H, Hafezi-Moghadam A, Ishibashi T.

    Diabetes. 2009 Jan;58(1):215-26. Epub 2008 Oct 7.PMID: 18840783 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.

    Xie Z, Su W, Guo Z, Pang H, Post SR, Gong MC.

    Cardiovasc Res. 2006 Feb 1;69(2):491-501. Epub 2005 Dec 5.PMID: 16336954 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway.

    Chen XY, Dun JN, Miao QF, Zhang YJ.

    Pharmacology. 2009;83(2):67-79. Epub 2008 Dec 4.PMID: 19052484 [PubMed - indexed for MEDLINE]Related articles

    7.

    Statins suppress MMP2 secretion via inactivation of RhoA/ROCK pathway in pulmonary vascular smooth muscles cells.

    Li M, Li Z, Sun X.

    Eur J Pharmacol. 2008 Sep 4;591(1-3):219-23. Epub 2008 Jun 27.PMID: 18619957 [PubMed - indexed for MEDLINE]Related articles

    8.

    3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy.

    Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS.

    Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8301-5. Epub 2002 Jun 4.PMID: 12048257 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells.

    Itoh Y, Kimoto K, Imaizumi M, Nakatsuka K.

    Exp Eye Res. 2007 Mar;84(3):464-72. Epub 2007 Jan 10.PMID: 17217948 [PubMed - indexed for MEDLINE]Related articles

    10.

    Effects of mycophenolate mofetil on chronic allograft nephropathy by affecting RHO/ROCK signal pathways.

    Song J, Lu YP, Luo GH, Yang L, Ma X, Xia QJ, Shi YJ, Li YP.

    Transplant Proc. 2008 Oct;40(8):2790-4.PMID: 18929863 [PubMed - indexed for MEDLINE]Related articles

    11.

    Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways.

    Rodrigues-Díez R, Carvajal-González G, Sánchez-López E, Rodríguez-Vita J, Rodrigues Díez R, Selgas R, Ortiz A, Egido J, Mezzano S, Ruiz-Ortega M.

    Pharm Res. 2008 Oct;25(10):2447-61. Epub 2008 Jul 16.PMID: 18633694 [PubMed - indexed for MEDLINE]Related articles

    12.

    HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation.

    Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR.

    Am J Physiol Renal Physiol. 2006 Nov;291(5):F995-1004. Epub 2006 Jun 13.PMID: 16774905 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice.

    Fujii M, Inoguchi T, Maeda Y, Sasaki S, Sawada F, Saito R, Kobayashi K, Sumimoto H, Takayanagi R.

    Kidney Int. 2007 Aug;72(4):473-80. Epub 2007 Jun 13.PMID: 17568784 [PubMed - indexed for MEDLINE]Related articles

    14.

    Atorvastatin ameliorates sildenafil-induced penile erections in experimental diabetes by inhibiting diabetes-induced RhoA/Rho-kinase signaling hyperactivation.

    Morelli A, Chavalmane AK, Filippi S, Fibbi B, Silvestrini E, Sarchielli E, Zhang XH, Vignozzi L, Vannelli GB, Forti G, Maggi M.

    J Sex Med. 2009 Jan;6(1):91-106.PMID: 19170840 [PubMed - indexed for MEDLINE]Related articles

    15.

    Signaling through Rho GTPase pathway as viable drug target.

    Lu Q, Longo FM, Zhou H, Massa SM, Chen YH.

    Curr Med Chem. 2009;16(11):1355-65.PMID: 19355891 [PubMed - indexed for MEDLINE]Related articles

    16.

    Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats.

    Li F, Xia W, Li A, Zhao C, Sun R.

    Pharmacol Res. 2007 Jan;55(1):64-71. Epub 2006 Nov 1.PMID: 17127075 [PubMed - indexed for MEDLINE]Related articles

    17.

    Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.

    Rashid M, Tawara S, Fukumoto Y, Seto M, Yano K, Shimokawa H.

    Circ J. 2009 Feb;73(2):361-70. Epub 2008 Dec 8.PMID: 19060417 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats.

    Kikuchi Y, Yamada M, Imakiire T, Kushiyama T, Higashi K, Hyodo N, Yamamoto K, Oda T, Suzuki S, Miura S.

    J Endocrinol. 2007 Mar;192(3):595-603.PMID: 17332527 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats.

    Nishikimi T, Akimoto K, Wang X, Mori Y, Tadokoro K, Ishikawa Y, Shimokawa H, Ono H, Matsuoka H.

    J Hypertens. 2004 Sep;22(9):1787-96.PMID: 15311108 [PubMed - indexed for MEDLINE]Related articles

    20.

    Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats.

    Nishikimi T, Koshikawa S, Ishikawa Y, Akimoto K, Inaba C, Ishimura K, Ono H, Matsuoka H.

    J Hypertens. 2007 May;25(5):1053-63.PMID: 17414670 [PubMed - indexed for MEDLINE]Related articles

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