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    Results: 1 to 20 of 307

    1.

    Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.

    Calvert JW, Gundewar S, Jha S, Greer JJ, Bestermann WH, Tian R, Lefer DJ.

    Diabetes. 2008 Mar;57(3):696-705. Epub 2007 Dec 14.PMID: 18083782 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase.

    Davis BJ, Xie Z, Viollet B, Zou MH.

    Diabetes. 2006 Feb;55(2):496-505.PMID: 16443786 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species.

    Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WG 4th, Schlattner U, Neumann D, Brownlee M, Freeman MB, Goldman MH.

    J Biol Chem. 2004 Oct 15;279(42):43940-51. Epub 2004 Jul 19.PMID: 15265871 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure.

    Gundewar S, Calvert JW, Jha S, Toedt-Pingel I, Ji SY, Nunez D, Ramachandran A, Anaya-Cisneros M, Tian R, Lefer DJ.

    Circ Res. 2009 Feb 13;104(3):403-11. Epub 2008 Dec 18.PMID: 19096023 [PubMed - indexed for MEDLINE]Related articles

    5.

    Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24 hours after administration.

    Solskov L, Løfgren B, Kristiansen SB, Jessen N, Pold R, Nielsen TT, Bøtker HE, Schmitz O, Lund S.

    Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):82-7. Epub 2008 Jul 1.PMID: 18484962 [PubMed - indexed for MEDLINE]Related articles

    6.

    Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide.

    Gonon AT, Widegren U, Bulhak A, Salehzadeh F, Persson J, Sjöquist PO, Pernow J.

    Cardiovasc Res. 2008 Apr 1;78(1):116-22. Epub 2008 Jan 25.PMID: 18222959 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice.

    Das A, Salloum FN, Xi L, Rao YJ, Kukreja RC.

    Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1236-43. Epub 2009 Mar 13.PMID: 19286961 [PubMed - indexed for MEDLINE]Related articles

    8.

    The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

    Fryer LG, Parbu-Patel A, Carling D.

    J Biol Chem. 2002 Jul 12;277(28):25226-32. Epub 2002 May 6.PMID: 11994296 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway.

    Levine YC, Li GK, Michel T.

    J Biol Chem. 2007 Jul 13;282(28):20351-64. Epub 2007 May 22.PMID: 17519230 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions.

    Gaskin FS, Kamada K, Yusof M, Korthuis RJ.

    Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H326-32. Epub 2006 Aug 25.PMID: 16935999 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms.

    Saeedi R, Parsons HL, Wambolt RB, Paulson K, Sharma V, Dyck JR, Brownsey RW, Allard MF.

    Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2497-506. Epub 2008 Mar 28.PMID: 18375721 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.

    Hamid SA, Bower HS, Baxter GF.

    Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2598-606. Epub 2007 Jan 12.PMID: 17220176 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP.

    Kim YD, Park KG, Lee YS, Park YY, Kim DK, Nedumaran B, Jang WG, Cho WJ, Ha J, Lee IK, Lee CH, Choi HS.

    Diabetes. 2008 Feb;57(2):306-14. Epub 2007 Oct 1.PMID: 17909097 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

    Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC.

    Science. 2005 Dec 9;310(5754):1642-6. Epub 2005 Nov 24.PMID: 16308421 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects.

    Luna V, Casauban L, Sajan MP, Gomez-Daspet J, Powe JL, Miura A, Rivas J, Standaert ML, Farese RV.

    Diabetologia. 2006 Feb;49(2):375-82. Epub 2006 Jan 5.PMID: 16395615 [PubMed - indexed for MEDLINE]Related articles

    16.

    Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

    Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA.

    Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31. Epub 2004 Feb 10.PMID: 14871885 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.

    Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B, Sadoshima J.

    Circ Res. 2007 Mar 30;100(6):914-22. Epub 2007 Mar 1.PMID: 17332429 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase.

    Schulz E, Anter E, Zou MH, Keaney JF Jr.

    Circulation. 2005 Jun 28;111(25):3473-80. Epub 2005 Jun 20.PMID: 15967841 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Sildenafil-mediated acute cardioprotection is independent of the NO/cGMP pathway.

    Elrod JW, Greer JJ, Lefer DJ.

    Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H342-7. Epub 2006 Sep 1.PMID: 16951048 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    H11 kinase prevents myocardial infarction by preemptive preconditioning of the heart.

    Depre C, Wang L, Sui X, Qiu H, Hong C, Hedhli N, Ginion A, Shah A, Pelat M, Bertrand L, Wagner T, Gaussin V, Vatner SF.

    Circ Res. 2006 Feb 3;98(2):280-8. Epub 2005 Dec 22.PMID: 16373598 [PubMed - indexed for MEDLINE]Related articlesFree article

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