PubMed

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

Risérus U, Sprecher D, Johnson T, Olson E, Hirschberg S, Liu A, Fang Z, Hegde P, Richards D, Sarov-Blat L, Strum JC, Basu S, Cheeseman J, Fielding BA, Humphreys SM, Danoff T, Moore NR, Murgatroyd P, O'Rahilly S, Sutton P, Willson T, Hassall D, Frayn KN, Karpe F.

Diabetes. 2008 Feb;57(2):332-9. Epub 2007 Nov 16.PMID: 18024853 [PubMed - indexed for MEDLINE]Related articlesFree article

Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.

Sprecher DL, Massien C, Pearce G, Billin AN, Perlstein I, Willson TM, Hassall DG, Ancellin N, Patterson SD, Lobe DC, Johnson TG.

Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):359-65. Epub 2006 Nov 16.PMID: 17110604 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor delta-agonist, GW501516, ameliorates insulin resistance, improves dyslipidaemia in monosodium L-glutamate metabolic syndrome mice.

Chen W, Wang LL, Liu HY, Long L, Li S.

Basic Clin Pharmacol Toxicol. 2008 Sep;103(3):240-6. Epub 2008 Jul 18.PMID: 18684227 [PubMed - indexed for MEDLINE]Related articles

Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet.

Nagasawa T, Inada Y, Nakano S, Tamura T, Takahashi T, Maruyama K, Yamazaki Y, Kuroda J, Shibata N.

Eur J Pharmacol. 2006 Apr 24;536(1-2):182-91. Epub 2006 Feb 28.PMID: 16574099 [PubMed - indexed for MEDLINE]Related articles

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.

Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15924-9. Epub 2003 Dec 15.PMID: 14676330 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of PPAR-delta in isolated rat skeletal muscle switches fuel preference from glucose to fatty acids.

Brunmair B, Staniek K, Dörig J, Szöcs Z, Stadlbauer K, Marian V, Gras F, Anderwald C, Nohl H, Waldhäusl W, Fürnsinn C.

Diabetologia. 2006 Nov;49(11):2713-22. Epub 2006 Sep 8.PMID: 16960684 [PubMed - indexed for MEDLINE]Related articles

Roles of peroxisome proliferator-activated receptor delta (PPARdelta) in the control of fatty acid catabolism. A new target for the treatment of metabolic syndrome.

Luquet S, Lopez-Soriano J, Holst D, Gaudel C, Jehl-Pietri C, Fredenrich A, Grimaldi PA.

Biochimie. 2004 Nov;86(11):833-7. Review.PMID: 15589693 [PubMed - indexed for MEDLINE]Related articles

The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells.

Dressel U, Allen TL, Pippal JB, Rohde PR, Lau P, Muscat GE.

Mol Endocrinol. 2003 Dec;17(12):2477-93. Epub 2003 Oct 2.PMID: 14525954 [PubMed - indexed for MEDLINE]Related articlesFree article

The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells.

Dimopoulos N, Watson M, Green C, Hundal HS.

FEBS Lett. 2007 Oct 2;581(24):4743-8. Epub 2007 Sep 6.PMID: 17869249 [PubMed - indexed for MEDLINE]Related articles

Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.

Krämer DK, Al-Khalili L, Guigas B, Leng Y, Garcia-Roves PM, Krook A.

J Biol Chem. 2007 Jul 6;282(27):19313-20. Epub 2007 May 11.PMID: 17500064 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study.

Jucker BM, Yang D, Casey WM, Olzinski AR, Williams C, Lenhard SC, Legos JJ, Hawk CT, Sarkar SK, Newsholme SJ.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1256-64. Epub 2007 Aug 28.PMID: 17726146 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta.

Krämer DK, Al-Khalili L, Perrini S, Skogsberg J, Wretenberg P, Kannisto K, Wallberg-Henriksson H, Ehrenborg E, Zierath JR, Krook A.

Diabetes. 2005 Apr;54(4):1157-63.PMID: 15793256 [PubMed - indexed for MEDLINE]Related articlesFree article

A dual PPAR alpha/gamma agonist increases adiponectin and improves plasma lipid profiles in healthy subjects.

Decochez K, Rippley RK, Miller JL, De Smet M, Yan KX, Matthijs Z, Riffel KA, Song H, Zhu H, Maynor HO, Tanaka W, Johnson-Levonas AO, Davies MJ, Gottesdiener KM, Keymeulen B, Wagner JA.

Drugs R D. 2006;7(2):99-110.PMID: 16542056 [PubMed - indexed for MEDLINE]Related articles

Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes.

Watt MJ, Southgate RJ, Holmes AG, Febbraio MA.

J Mol Endocrinol. 2004 Oct;33(2):533-44.PMID: 15525607 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinoic acid treatment increases lipid oxidation capacity in skeletal muscle of mice.

Amengual J, Ribot J, Bonet ML, Palou A.

Obesity (Silver Spring). 2008 Mar;16(3):585-91. Epub 2008 Jan 17.PMID: 18239600 [PubMed - indexed for MEDLINE]Related articles

In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats.

Yue TL, Nerurkar SS, Bao W, Jucker BM, Sarov-Blat L, Steplewski K, Ohlstein EH, Willette RN.

J Pharmacol Exp Ther. 2008 May;325(2):466-74. Epub 2008 Feb 20.PMID: 18287212 [PubMed - indexed for MEDLINE]Related articlesFree article

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.

Oliver WR Jr, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11. Epub 2001 Apr 17.PMID: 11309497 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of peroxisome proliferator-activated receptor alpha/delta agonists on HDL-cholesterol in vervet monkeys.

Wallace JM, Schwarz M, Coward P, Houze J, Sawyer JK, Kelley KL, Chai A, Rudel LL.

J Lipid Res. 2005 May;46(5):1009-16. Epub 2005 Feb 16.PMID: 15716581 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome.

Takahashi S, Tanaka T, Kodama T, Sakai J.

Pharmacol Res. 2006 Jun;53(6):501-7. Epub 2006 Mar 29. Review.PMID: 16713711 [PubMed - indexed for MEDLINE]Related articles

Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise.

Kannisto K, Chibalin A, Glinghammar B, Zierath JR, Hamsten A, Ehrenborg E.

Int J Mol Med. 2006 Jan;17(1):45-52.PMID: 16328010 [PubMed - indexed for MEDLINE]Related articles